Background: To investigate the effects of unsafe decompression on rat pulmonary endothelial function and its relevant mechanisms.Methods: Sixty male Sprague-Dawley(SD) rats were randomly divided into a control group(n...Background: To investigate the effects of unsafe decompression on rat pulmonary endothelial function and its relevant mechanisms.Methods: Sixty male Sprague-Dawley(SD) rats were randomly divided into a control group(n=30) and a decompression sickness(DCS) group(n=30). The DCS model was established by placing the rats in the DCS group in a pressurized cabin where they were exposed to a 600 k Pa compressed air environment for 60 min, and the pressure was then reduced by 100 k Pa/min until it reached atmospheric pressure. After the surviving rats in the DCS group and the rats in the control group were anesthetized, their pulmonary arteries were stripped to test the in vitro pulmonary artery endothelium-dependent vasodilation capacity. Western blotting was used to measure the expression and dissociation of endothelial nitric oxide synthase(e NOS) in pulmonary artery tissues and all protein nitration levels in pulmonary artery tissues; reactive oxygen species(ROS) formation was measured via in vitro pulmonary artery superoxide anion probe dihydroethidium(DHE) staining.Results: After experiencing unsafe decompression, 10 of the 30 rats in the DCS group died. The pulmonary artery endothelium-dependent vasodilation capacity in the surviving rats decreased significantly(P<0.05). The difference in e NOS expression between the DCS group and the control group was statistically insignificant(P>0.05), but the ratio of e NOS monomer/dimer in the DCS group was significantly higher than that in the control group(P<0.05). All protein tyrosine nitration levels in the pulmonary artery tissues of the DCS group were significantly higher than those of the control group(P<0.05). The results of DHE staining showed that the amount of ROS formation in the pulmonary arteries of the DCS group was significantly higher than that of the control group(P<0.05).Conclusion: Unsafe decompression during a simulated submarine escape process can lead to e NOS dimer uncoupling in the pulmonary artery endothelium. The dissociated e NOS monomer cannot synthesize nitric oxide(NO) and thus affect the endothelium-dependent vasodilation capacity. The e NOS monomer can promote peroxynitrite(ONOO–) synthesis, leading to an increase in protein tyrosine nitration levels in pulmonary artery tissues and causing disorder in cell cycle regulation. The e NOS monomer can also cause an increase in the formation of ROS and thus mediate peroxidation damage.展开更多
Background & Objectives: Hepatocellular carcinoma (HCC) leads to high morbidity and mortality. Various models have been proposed for predicting the outcome of patients with HCC. We aim to compare the prognostic ab...Background & Objectives: Hepatocellular carcinoma (HCC) leads to high morbidity and mortality. Various models have been proposed for predicting the outcome of patients with HCC. We aim to compare the prognostic abilities of Child-Pugh, MELD, MELD-Na, and ALBI scores for predicting in-hospital mortality of HCC. Methods: We enrolled patients diagnosed with liver cirrhosis and HCC from May 2017 through May 2018. We further divided eligible patients into hepatitis B virus (HBV), patients without ascites, and patients with ascites subgroups. Areas under the characteristic curves (AUCs) were analyzed. Results: A total of 495 patients were included in the study. We collected data on patients at admission. A majority of patients were infected with HBV (91.5%). None of them were complicated with hepatic encephalopathy. Only 14.9% of patients presented with ascites. In the whole population, AUCs with 95% confidence interval (CI) of Child-Pugh, ALBI, MELD, and MELD-Na scores in predicting in-hospital mortality were 0.889 (95% CI: 0.858 - 0.915), 0.849 (95% CI: 0.814 - 0.879), 0.669 (95% CI: 0.626 - 0.711), and 0.721 (95% CI: 0.679 - 0.760), respectively. In the patients without ascites subgroup, Child-Pugh showed better discriminatory ability than ALBI score in predicting in-hospital mortality (P = 0.0002), while there were no significant differences among other comparisons. Conclusions: Child-Pugh and ALBI may be useful predictors for predicting in-hospital mortality in whole patients, in patients with HBV infection, and in patients without ascites. In HCC patients with ascites, MELD-Na may be effective for predicting in-hospital mortality.展开更多
Competition of excellent teachers and talents has increasingly become a key element of global higher education competition at present. The sustainable and efficient international education development of university te...Competition of excellent teachers and talents has increasingly become a key element of global higher education competition at present. The sustainable and efficient international education development of university teachers and the expansion and promotion of their international vision and ability are the key areas and important contents for the intensive development of China’s higher education. Compared with the economically developed provinces, the current international development of Anhui university teachers is not optimistic, and the existing problems are obvious. Aiming at removing bottleneck in the development, this paper put forward specific practical strategies in the development orientation, management system and mechanism, space expansion, language enhancement and financial guarantee, based on the comparative research and analysis between Anhui and other provinces, it effectively promotes the development process of Anhui university teachers from international perspective.展开更多
A novel [1＋1] Schiff-base macrocyclic compound 3 has been synthesized from precursor 1, 1,3-bis（2＇- formylphenoxy）-2-propanol, and precursor 2, resorcinol-bis（4-aminophenyl）ether, via condensation and cyclizacti...A novel [1＋1] Schiff-base macrocyclic compound 3 has been synthesized from precursor 1, 1,3-bis（2＇- formylphenoxy）-2-propanol, and precursor 2, resorcinol-bis（4-aminophenyl）ether, via condensation and cyclizaction using Ba2＋ as template. The macrocycle 3 was further reduced giving saturated macrocycle 4. The structures of 3 and 4 were characterized by elemental analysis, ~H NMR, IR, and MS spectra, and their structures were determined via single crystal X-ray diffraction studies. X-ray diffraction analysis revealed that the macrocyclic compound 3 has a folded conformation, and the corresponding reduced product 4 adopts a twisted and folded conformation due to its flexible nature. ~ 2013 Bi-Xue Zhu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
Along with the survey on experimental investigations drawing attention to the drag and heat reduction mechanism, the authors simultaneously focus on the recent advances of numerical simulations on the schemes applied ...Along with the survey on experimental investigations drawing attention to the drag and heat reduction mechanism, the authors simultaneously focus on the recent advances of numerical simulations on the schemes applied to supersonic/hypersonic vehicles. The CFD study has evolved as an irreplaceable method in scheme evaluation and aircraft optimization. Similar to our previous experimental survey, the advances in drag and heat reduction schemes are reviewed by similar kinds of mechanism in this article, namely the forward-facing cavity, the opposing jet, the aerospike, the energy deposition and their combinational configurations. This review article puts an emphatic eye on the flow conditions, numerical methods, novel schemes and analytical conclusions given in the simulations. Further, the multi-objective design optimization concept has also been illustrated due to the observable advantages of using CFD over experimental method, especially those performances conducted in drag reduction and thermal protection practice, and this would possess reference value in the design of aircraft system.展开更多
基金supported by the Army on the Subject of China (10ZYZ219)
文摘Background: To investigate the effects of unsafe decompression on rat pulmonary endothelial function and its relevant mechanisms.Methods: Sixty male Sprague-Dawley(SD) rats were randomly divided into a control group(n=30) and a decompression sickness(DCS) group(n=30). The DCS model was established by placing the rats in the DCS group in a pressurized cabin where they were exposed to a 600 k Pa compressed air environment for 60 min, and the pressure was then reduced by 100 k Pa/min until it reached atmospheric pressure. After the surviving rats in the DCS group and the rats in the control group were anesthetized, their pulmonary arteries were stripped to test the in vitro pulmonary artery endothelium-dependent vasodilation capacity. Western blotting was used to measure the expression and dissociation of endothelial nitric oxide synthase(e NOS) in pulmonary artery tissues and all protein nitration levels in pulmonary artery tissues; reactive oxygen species(ROS) formation was measured via in vitro pulmonary artery superoxide anion probe dihydroethidium(DHE) staining.Results: After experiencing unsafe decompression, 10 of the 30 rats in the DCS group died. The pulmonary artery endothelium-dependent vasodilation capacity in the surviving rats decreased significantly(P<0.05). The difference in e NOS expression between the DCS group and the control group was statistically insignificant(P>0.05), but the ratio of e NOS monomer/dimer in the DCS group was significantly higher than that in the control group(P<0.05). All protein tyrosine nitration levels in the pulmonary artery tissues of the DCS group were significantly higher than those of the control group(P<0.05). The results of DHE staining showed that the amount of ROS formation in the pulmonary arteries of the DCS group was significantly higher than that of the control group(P<0.05).Conclusion: Unsafe decompression during a simulated submarine escape process can lead to e NOS dimer uncoupling in the pulmonary artery endothelium. The dissociated e NOS monomer cannot synthesize nitric oxide(NO) and thus affect the endothelium-dependent vasodilation capacity. The e NOS monomer can promote peroxynitrite(ONOO–) synthesis, leading to an increase in protein tyrosine nitration levels in pulmonary artery tissues and causing disorder in cell cycle regulation. The e NOS monomer can also cause an increase in the formation of ROS and thus mediate peroxidation damage.
文摘Background & Objectives: Hepatocellular carcinoma (HCC) leads to high morbidity and mortality. Various models have been proposed for predicting the outcome of patients with HCC. We aim to compare the prognostic abilities of Child-Pugh, MELD, MELD-Na, and ALBI scores for predicting in-hospital mortality of HCC. Methods: We enrolled patients diagnosed with liver cirrhosis and HCC from May 2017 through May 2018. We further divided eligible patients into hepatitis B virus (HBV), patients without ascites, and patients with ascites subgroups. Areas under the characteristic curves (AUCs) were analyzed. Results: A total of 495 patients were included in the study. We collected data on patients at admission. A majority of patients were infected with HBV (91.5%). None of them were complicated with hepatic encephalopathy. Only 14.9% of patients presented with ascites. In the whole population, AUCs with 95% confidence interval (CI) of Child-Pugh, ALBI, MELD, and MELD-Na scores in predicting in-hospital mortality were 0.889 (95% CI: 0.858 - 0.915), 0.849 (95% CI: 0.814 - 0.879), 0.669 (95% CI: 0.626 - 0.711), and 0.721 (95% CI: 0.679 - 0.760), respectively. In the patients without ascites subgroup, Child-Pugh showed better discriminatory ability than ALBI score in predicting in-hospital mortality (P = 0.0002), while there were no significant differences among other comparisons. Conclusions: Child-Pugh and ALBI may be useful predictors for predicting in-hospital mortality in whole patients, in patients with HBV infection, and in patients without ascites. In HCC patients with ascites, MELD-Na may be effective for predicting in-hospital mortality.
文摘Competition of excellent teachers and talents has increasingly become a key element of global higher education competition at present. The sustainable and efficient international education development of university teachers and the expansion and promotion of their international vision and ability are the key areas and important contents for the intensive development of China’s higher education. Compared with the economically developed provinces, the current international development of Anhui university teachers is not optimistic, and the existing problems are obvious. Aiming at removing bottleneck in the development, this paper put forward specific practical strategies in the development orientation, management system and mechanism, space expansion, language enhancement and financial guarantee, based on the comparative research and analysis between Anhui and other provinces, it effectively promotes the development process of Anhui university teachers from international perspective.
基金supported by the National Natural Science Foundation of China(No.21061003)he International Collaborative Project of Guizhou Province(No.[2009]700104)the Natural Science Foundation of the Guizhou Province(No.(2012)2151)
文摘A novel [1＋1] Schiff-base macrocyclic compound 3 has been synthesized from precursor 1, 1,3-bis（2＇- formylphenoxy）-2-propanol, and precursor 2, resorcinol-bis（4-aminophenyl）ether, via condensation and cyclizaction using Ba2＋ as template. The macrocycle 3 was further reduced giving saturated macrocycle 4. The structures of 3 and 4 were characterized by elemental analysis, ~H NMR, IR, and MS spectra, and their structures were determined via single crystal X-ray diffraction studies. X-ray diffraction analysis revealed that the macrocyclic compound 3 has a folded conformation, and the corresponding reduced product 4 adopts a twisted and folded conformation due to its flexible nature. ~ 2013 Bi-Xue Zhu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金support from the National Natural Science Foundation of China (Nos.11502291 & 11802340)
文摘Along with the survey on experimental investigations drawing attention to the drag and heat reduction mechanism, the authors simultaneously focus on the recent advances of numerical simulations on the schemes applied to supersonic/hypersonic vehicles. The CFD study has evolved as an irreplaceable method in scheme evaluation and aircraft optimization. Similar to our previous experimental survey, the advances in drag and heat reduction schemes are reviewed by similar kinds of mechanism in this article, namely the forward-facing cavity, the opposing jet, the aerospike, the energy deposition and their combinational configurations. This review article puts an emphatic eye on the flow conditions, numerical methods, novel schemes and analytical conclusions given in the simulations. Further, the multi-objective design optimization concept has also been illustrated due to the observable advantages of using CFD over experimental method, especially those performances conducted in drag reduction and thermal protection practice, and this would possess reference value in the design of aircraft system.
