Food intolerance and skin prick test in treated and untreated irritable bowel syndrome

瞄准：相关临床的特征对待并且有到皮肤的结果的急躁的肠症候群(IBS ) 的未经治疗的病人为食物和被吸入的东西变应原刺测试(SPT ) 。方法：我们招募了 105 个对象形成三个不同目标组：为 IBS 经历治疗的对待的组(n=44 ) ，没有治疗，为 IBS 满足罗马 II 标准的未经治疗的组(n=31 ) ，没有 IBS 症状的控制组(n=30 ) 。结果：SPT 结果在在哪个 SPT 是积极的在里面(38.6%) 17 对待病人的三个组之中是不同的，在 5 (16.1%) 未经治疗的病人并且在 1 (3.3%) 控制(P【0.01 ) 。积极 SPT 的数字比在控制组(P【0.001 ) 在 IBS 组是更大的。积极食物 SPT 的数字比在未经治疗的 IBS 组(P=0.03 ) 在对待的 IBS 组是更高的。结论：积极食物 SPT 比在控制在 IBS 病人是更高的。

Calcium channel blocker monotherapy versus combination with reninangiotensin system inhibitors on the development of new-onset diabetes mellitus in hypertensive Korean patients

Background In real practice, two or more antihypertensive drugs are needed to achieve target blood pressure. We investigated the comparative beneficial actions of combination therapy of renin-angiotensin system inhibitors (RASI), with calcium channel blockers (CCB) over CCB monotherapy on the development of new-onset diabetes mellitus (NODM) in Korean patients during four-year follow-up periods. Methods A total of 3208 consecutive hypertensive patients without a history of diabetes mellitus who had been prescribed CCB were retrospectively enrolled from January 2004 to December 2012. These patients were divided into the two groups according to the additional use of RASI (the RASI group, n = 1221 and the no RASI group, n = 1987). Primary endpoint was NODM, defined as a fasting blood glucose ≥ 126 mg/dL or hemoglobin A1c ≥ 6.5%. Secondary endpoint was major adverse cardiac events (MACE) defined as total death, myocardial infarction (MI) and percutaneous coronary intervention (PCI). Results After propensity score-matched (PSM) analysis, two propensity- matched groups (939 pairs, n = 1878, C-statistic = 0.743) were generated. The incidences of NODM (HR = 1.009, 95% CI: 0.700–1.452, P = 0.962), MACE (HR = 0.877, 95% CI: 0.544–1.413, P = 0.589), total death, MI, PCI were similar between the two groups after PSM during four years. Conclusions The use of RASI in addition to CCB showed comparable incidences of NODM and MACE compared to CCB monotherapy in non-diabetic hypertensive Korean patients during four-year follow-up period. However, large-scaled randomized controlled clinical trials will be required for a more definitive conclusion.

Safety and efficacy of transradial coronary angiography and intervention in patients older than 80 years： from the Korean Transradial Intervention Prospective Registry

为冠的过程的 BackgroundRadial 动脉存取是一种安全、有益的技术。然而，当存取地点的一个更高的风险组与更年轻的病人相比联系了复杂并发症，老病人被考虑了。这研究被进行调查 transradial 的可行性和安全在从在 20 个中心的朝鲜 Transradial 干预未来的登记的 6132 个病人的 elderly.MethodsA 总数的冠的 angiography 或干预被分析。病人们被划分成非老的组(n = 5667 ) 并且老(80 年) 组织(n = 465 ) 。用倾向分数匹配，老组(n = 465 ) 与相比一对一匹配非老的组(n = 465 ).ResultsAfter 倾向 20 匹配的、吝啬的年龄是 64.3 汵琠敲瑡敭瑮漠 ? 湩牴捡牡楤捡愠物攠扭汯獩 ? 獵湩 ? 湩牴捡牡楤捡挠瑡敨整 ?

Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention

Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years.

Assessment of risk of complications in cirrhosis using portal thallium scans

AIM:To investigate the usefulness of a novel thallium scan shunt index for assessing portosystemic shuntrelated cirrhotic complications.METHODS:We enrolled 209 chronic hepatitis B-related cirrhosis patients.After rectal thallium instillation,radioactive isotope activity in the heart and liver was measured.The ratio of radiation uptake between the heart and the liver was calculated(the shunt index).This value indicates the degree of portosystemic circulation shunting.Blood tests,serum biochemistry tests,abdominal ultrasonography,gastroscopy and examination of clinical features such as the occurrence of varices,bleeding and hepatic encephalopathy were performed.Multivariate analysis was used to identify independent risk factors for complications.We compared the cumulative incidence rates of complications during the follow-up period.RESULTS:The thallium scan shunt index was significantly higher in the decompensated liver cirrhosis group than in the compensated liver cirrhosis group(0.91±0.39 vs 0.39±0.32,P<0.001).It was also higher in the varices group,the hepatic encephalopathy group,and the variceal bleeding group than in the control group(P<0.001).Multivariate analysis showed that the index was an independent risk factor for predicting decompensated liver cirrhosis.When the cut-off value was 0.75,the shunt index had a sensitivity of 82.6%,a specificity of 84%,a positive predictive value of 61.5%,and a negative predictive value of 94.4%in diagnosing decompensated cirrhosis.When the shunt index was greater than 0.75,there was a significant increase in the number of decompensated events.CONCLUSION:The thallium shunt index is a good predictor of cirrhosis-related complications.

Successful extracorporeal life support in sudden cardiac arrest due to coronary anomaly

Extracorporeal life support(ECLS) has recently been reported to have a survival benefit in patients with cardiac arrest. It is now used widely as a lifesaving modality. Here, we describe a case of sudden cardiac arrest(SCA) in a young athlete with an anomalous origin of the right coronary artery from the left coronary sinus. Resuscitation was successful using ECLS before curative bypass surgery. We highlight the efficacy of ECLS for a patient with SCA caused by a rare, unexpected aetiology. In conclusion, ECLS was a lifesaving modality for SCA due to an anomalous coronary artery in this young patient.

Effects of Chairside Polishing and Brushing on SurfaceRoughness of Acrylic Denture Base Resins

The effects of 3 chairside polishing kits and mechanical brushing on the surface roughness of 3 different acrylic denture base resins were compared. Acrylic denture base resins （auto-polymerizing, heat-polymerizing, injected heat-polymerizing resins） were examined after a tungsten carbide bur, and after chairside polishing using 3 polishing kits and pumice. The specimens were subjected to mechanical brushing using a wear tester to simulate 30 000 strokes of brushing. The surface roughness of the acrylic denture base resin specimens was measured using a contact pro-filometer. After the test, the random polished acrylic resins were evaluated by scanning electron mi-croscopy （SEM） and atomic force microscopy （AFM）. Acrylic denture base resins polished using the 3 types of polishing kits had a smoother surface than those finished with the tungsten carbide bur （p〈0.05）. The surface of the resin polished by a TC cutter exceeded the Ra of 0.2 μm （p〈0.05）. The auto-polymerizing resin showed a significantly higher surface roughness than the heat-polymerizing resin and injected heat-polymerizing resin （p〉0.05）. In the case of polishing step wise, there was almost no change in surface roughness after brushing （p〉0.05）.

Comparative Study of Visual and Instrumental Analyses of Shade Selection

The difference between visual and instrumental analyses of a shade selection on natural teeth was investigated. With visual analysis, five prosthodontist examined the middle third of the unrestored maxillary right central incisor of a patient using VITAPEN classical and Vita Toothguide 3D-MASTER tooth shade guide. In instrumental analysis, one prosthodontist examined the same teeth using a spectrophotometer （ShadepilotTM, Degudent, Hanau-Wolfgang, Germany, software 2.40）. Overall, instrumental analysis is more accurate and reproducible than a visual assessment. However, the difference is clinically acceptable.

表面改性钛膜和原始钛膜对大鼠颅骨缺损模型引导骨再生的比较研究

研究目的：本研究的目的是评价经过阳极氧化、循环预矿化、加热处理钛膜（APHTM）的生物活性，采用组织学分析和显微CT扫描（Micro-CT）比较APHTM和未处理钛膜（NTTM）的引导骨再生能力。材料与方法：制备APHTM样品并浸泡于模拟体液中2天，然后用场发射扫描电子显微镜观察，接着用X射线能谱分析钙和磷酸盐的沉淀情况。体内实验中，在大鼠颅骨构造临界尺寸缺损（直径8mm）．用APHTM或NTTM覆盖处理（每一组n=14）。在2周和4周后活检进行组织学检查（n=3）。将骨荧光标记物在第3周（茜素红）和第5周（钙黄绿素）分别注射入每组三只大鼠，在第7周进行组织学分析，第8周进行Micro-CT扫描（n=5）。结果：APHTM具有较高的生物活性．于模拟体液浸泡2天后．APHTM表面特征性地遍布致密的纳米片状晶体、钙磷浓度增加。在2周和4周，APHTM组显示新生骨紧密贴附于膜上．而NTTM样品组在膜和新生骨之间形成结缔组织间隔。在荧光分析中也发现了同样的规律。Micro-CT分析显示．APHTM组较NTTM组骨量低，但骨矿化密度更高（P〈005）。结论：结果表明，用APH处理钛膜可促进膜与新成骨之间紧密贴合，从而提高骨再生结构的稳定性。还需要进一步体内和体外实验验证该结论。