Acupuncture has been broadly used as a major therapeutic tool for at least 2,100 years in East Asia. Acupuncture is used for improving the pathological condition of remote organs, such as stomach, liver, brain, etc. b...Acupuncture has been broadly used as a major therapeutic tool for at least 2,100 years in East Asia. Acupuncture is used for improving the pathological condition of remote organs, such as stomach, liver, brain, etc. by stimulating skin and muscle with fine metal needles through meridians which have been regarded as pathways of Qi within the body （Ernst, 2006）. Physicians in East Asia have tried to treat many kinds of diseases by acupuncture and it was considerably success- ful. Various diseases for which acupuncture is known to be effective, are neurological diseases, including sequelae of stroke, Alzheimer＇s disease （AD）, Parkinson＇s disease （PD）, and so on （Nam et al., 2013）.展开更多
Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design...Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted sites.Here,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical region.This device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated system.We demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological signals.We also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker stimulation.This platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.展开更多
基金supported by the project of National Junior Research Fellowship,which National Research Foundation of Korea conducts from 2012
文摘Acupuncture has been broadly used as a major therapeutic tool for at least 2,100 years in East Asia. Acupuncture is used for improving the pathological condition of remote organs, such as stomach, liver, brain, etc. by stimulating skin and muscle with fine metal needles through meridians which have been regarded as pathways of Qi within the body （Ernst, 2006）. Physicians in East Asia have tried to treat many kinds of diseases by acupuncture and it was considerably success- ful. Various diseases for which acupuncture is known to be effective, are neurological diseases, including sequelae of stroke, Alzheimer＇s disease （AD）, Parkinson＇s disease （PD）, and so on （Nam et al., 2013）.
基金support received from the National Research Foundation of Korea (Grant Nos.NRF-2019R1A2C2086085,NRF-2021R1A4A1031437,and NRF2018M3A7B4071109)support provided by the National Institutes of Health (Award Nos.R21EB030140,U01DA056242,and R61HL154215).
文摘Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted sites.Here,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical region.This device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated system.We demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological signals.We also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker stimulation.This platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.
