We present a study of the X-ray emission for a sample of radio-detected quasars constructed from the cross-matches between SDSS,FIRST catalogs and XMM-Newton archives.A sample of radio-quiet SDSS quasars without FIRST...We present a study of the X-ray emission for a sample of radio-detected quasars constructed from the cross-matches between SDSS,FIRST catalogs and XMM-Newton archives.A sample of radio-quiet SDSS quasars without FIRST radio detection is also assembled for comparison.We construct the optical and X-ray composite spectra normalized at rest frame 4215 A(or 2200 A)for both radio-loud quasars(RLQs)and radio-quiet quasars(RQQs)at z≤3.2,with matched X-ray completeness of 19%,redshift and optical luminosity.While the optical composite spectrum of RLQs is similar to that of RQQs,we find that RLQs have a higher X-ray composite spectrum than RQQs,consistent with previous studies in the literature.By dividing the radio-detected quasars into radio loudness bins,we find the X-ray composite spectra are generally higher with increasing radio loudness.Moreover,a significant correlation is found between the optical-to-X-ray spectral index and radio loudness,and there is a unified multi-correlation between the radio and X-ray luminosities and radio loudness in radio-detected quasars.These results could be possibly explained with the corona-jet model,in which the corona and jet are directly related.展开更多
BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)significantly improve the survival of patients with Epidermal growth factor receptor(EGFR)sensitive mutations in non-small cell lung can...BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)significantly improve the survival of patients with Epidermal growth factor receptor(EGFR)sensitive mutations in non-small cell lung cancer(NSCLC).CASE SUMMARY A 67-year-old female patient in advanced lung adenocarcinoma suffered from drug resistance after EGFR-TKIs treatment.Secondary pathological tissue biopsy confirmed squamous cell carcinoma(SCC)transformation.Patients inevitably encountered drug resistance issues after receiving EGFR-TKIs treatment for a certain period of time,while EGFR-TKIs can significantly improve the survival of patients with EGFR-sensitive mutations in NSCLC.Notably,EGFR-TKIs resistance includes primary and acquired.Pathological transformation is one of the mechanisms of acquired resistance in EGFR-TKIs,with SCC transformation being relatively rare.Our results provide more detailed results of the patient’s diagnosis and treatment process on SCC transformation after EGFR-TKIs treatment for lung adenocarcinoma.CONCLUSION Squamous cell carcinoma transformation is one of the acquired resistance mechanisms of EGFR-TKIs in advanced lung adenocarcinoma with EGFR mutations.展开更多
基金the National Natural Science Foundation of China(Grant Nos.11873073,U1531245,11773056 and U1831138)based on results from the enhanced XMMNewton spectral-fit database,an ESA PRODEX funded project,based in turn on observations obtained with XMMNewton,an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA+2 种基金Funding for SDSS-Ⅲhas been provided by the Alfred P.Sloan Foundationthe National Science Foundationthe U.S.Department of Energy Office of Science。
文摘We present a study of the X-ray emission for a sample of radio-detected quasars constructed from the cross-matches between SDSS,FIRST catalogs and XMM-Newton archives.A sample of radio-quiet SDSS quasars without FIRST radio detection is also assembled for comparison.We construct the optical and X-ray composite spectra normalized at rest frame 4215 A(or 2200 A)for both radio-loud quasars(RLQs)and radio-quiet quasars(RQQs)at z≤3.2,with matched X-ray completeness of 19%,redshift and optical luminosity.While the optical composite spectrum of RLQs is similar to that of RQQs,we find that RLQs have a higher X-ray composite spectrum than RQQs,consistent with previous studies in the literature.By dividing the radio-detected quasars into radio loudness bins,we find the X-ray composite spectra are generally higher with increasing radio loudness.Moreover,a significant correlation is found between the optical-to-X-ray spectral index and radio loudness,and there is a unified multi-correlation between the radio and X-ray luminosities and radio loudness in radio-detected quasars.These results could be possibly explained with the corona-jet model,in which the corona and jet are directly related.
文摘BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)significantly improve the survival of patients with Epidermal growth factor receptor(EGFR)sensitive mutations in non-small cell lung cancer(NSCLC).CASE SUMMARY A 67-year-old female patient in advanced lung adenocarcinoma suffered from drug resistance after EGFR-TKIs treatment.Secondary pathological tissue biopsy confirmed squamous cell carcinoma(SCC)transformation.Patients inevitably encountered drug resistance issues after receiving EGFR-TKIs treatment for a certain period of time,while EGFR-TKIs can significantly improve the survival of patients with EGFR-sensitive mutations in NSCLC.Notably,EGFR-TKIs resistance includes primary and acquired.Pathological transformation is one of the mechanisms of acquired resistance in EGFR-TKIs,with SCC transformation being relatively rare.Our results provide more detailed results of the patient’s diagnosis and treatment process on SCC transformation after EGFR-TKIs treatment for lung adenocarcinoma.CONCLUSION Squamous cell carcinoma transformation is one of the acquired resistance mechanisms of EGFR-TKIs in advanced lung adenocarcinoma with EGFR mutations.