有晶状体眼后房型人工晶状体植入术对高度近视的疗效

目的:通过双通道客观视觉质量分析系统Ⅱ(OQASⅡ)评价有晶状体眼后房型人工晶状体(ICL)植入术对高度近视的临床疗效。方法:选取2017-12/2018-12安徽医科大学第一附属医院收治的高度近视患者26例52眼,所有患者均行ICL植入术。随访获取所有患者术前BCVA以及术前和术后1wk,1、3mo的UCVA、客观散射指数(OSI)、调制传递函数(MTF)、斯特列尔比(SR)和100%、20%及9%的模拟对比度视力(Predicted VA)等一系列参数。结果:与术前BCVA相比,术后1wk,1、3mo UCVA情况均优于术前且日渐改善(P<0.01)。与术前OSI、MTF、SR和Predicted VA 100%、20%及9%相比,术后1wk,1、3mo情况均好转(P<0.01)。结论:ICL植入术能够有效地矫正高度近视,提高裸眼视力。通过OQASⅡ分析,ICL植入术后OSI比术前减小,术后的MTF、SR和Predicted VA 100%、20%及9%比术前均有提高,高度近视患者视觉质量得到良好的改善。

Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress

Previous studies suggest that serotonin （5-HT） might interact with brain-derived neurotrophic factor （BDNF） during the stress response. However, the relationship between 5-HT and BDNF expression under purely psychological stress is unclear. In this study, one hour before psychological stress exposure, the 5-HT1A receptor agonist 8-OH-DPAT or antagonist MDL73005, or the 5-HT2A receptor agonist DOI or antagonist ketanserin were administered to rats exposed to psychological stress. Immunohistochemistry and in situ hybridization revealed that after psychological stress, with the exception of the ventral tegmental area, BDNF protein and mRNA expression levels were higher in the 5-HT1A and the 5-HT2A receptor agonist groups compared with the solvent control no-stress or psychological stress group in the CA1 and CA3 of the hippocampus, prefrontal cortex, central amygdaloid nucleus, dorsomedial hypothalamic nucleus, dentate gyrus, shell of the nucleus accumbens and the midbrain periaqueductal gray. There was no significant difference between the two agonist groups. In contrast, after stress exposure, BDNF protein and mRNA expression levels were lower in the 5-HT1A and 5-HT2A receptor antagonist groups than in the solvent control non-stress group, with the exception of the ventral tegmental area. Our findings suggest that 5-HT regulates BDNF expression in a rat model of acute psychological stress.

Orexin might Predict Status of Alcohol Dependence

To the Editor:Alcohol dependence is a severe mental disorder that can have devastating physical and psychological impacts on patients.Alcohol dependence is reported to be one of the leading causes of death among people aged between 15 and 49 years.[1] Thus,comprehensive interventions are important for reducing mortality and disability among patients with alcohol dependence.[2]

Identification of Mutations in Myocilin and Beta-1,4-galactosyltransferase 3 Genes in a Chinese Family with Primary Open-angle Glaucoma

Background： Glaucoma is a major cause of irreversible blindness worldwide. There is evidence showing that a subset of the disease is genetically determined. In this study, we screened for mutations in chromosome lq-linked open-angle glaucoma （GLC1A） in a Chinese family with primary open-angle glaucoma （POAG）. Methods： A total of 23 members from five generations of a family were enrolled and underwent thorough ophthalmologic examinations. In addition, 200 unrelated healthy Chinese controls were also recruited as normal control. GLC1A gene was amplified by polymerase chain reaction, and DNA sequencing was performed to screen for mutations. Results： Six members were diagnosed as POAG, with severe clinical manifestations, and history of high intraocular pressures. The mean age of disease onset was 26.3 years. However, the others were asymptomatic. In six affected and three asymptomatic members, gene sequencing revealed a mutation c.C1456T in exon 3 of myocilin gene （MYOC）. Furthermore, we also identified a novel mutation c.G322A in beta- 1,4-galactosyltransferase 3 （B4GALT3） gene in all six affected and three asymptomatic members, which was not reported previously in POAG patients. The two newly identified variants were absent in other family members as well as controls. Conclusion： The mutations c.1456C〈T （p.L486F） in MYOC and c.322G〈A （p.V1081） in B4GALT3 are likely responsible for the pathogenesis of POAG in this family.