帕金森病(Parkinson's disease,PD)是以运动迟缓、肌强直、静止性震颤和姿势步态异常为特征的神经退行性疾病。近年来,经颅磁刺激(Transcranial magnetic stimulation,TMS)在PD运动障碍的诊治中取得了一定进展,不仅为PD的临床诊断...帕金森病(Parkinson's disease,PD)是以运动迟缓、肌强直、静止性震颤和姿势步态异常为特征的神经退行性疾病。近年来,经颅磁刺激(Transcranial magnetic stimulation,TMS)在PD运动障碍的诊治中取得了一定进展,不仅为PD的临床诊断提供了一种检测方法,且其重复模式即重复经颅磁刺激(Repetitive transcranial magnetic stimulation,rTMS)对帕金森病的运动症状也显示出积极的治疗前景。本文就rTMS技术在PD运动障碍中的作用原理、分子机制及临床研究现状进行综述。展开更多
Wheat embryo globulin(WEG)has been proven to possess multiple biological activities,including antioxidative properties,immunomodulatory,and so on.Aged mouse model were established by subcutaneous injection of D-galact...Wheat embryo globulin(WEG)has been proven to possess multiple biological activities,including antioxidative properties,immunomodulatory,and so on.Aged mouse model were established by subcutaneous injection of D-galactose(D-gal),and the effects of WEG on learning,memory,and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities determination.Compared with the Model group,WEG improved the percentage of the platform quadrant,increased the number of crossing platforms,and enhanced the identification indexs.WEG also increased total antioxidant capacity(T-AOC),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activities in the liver and brains of aging mice,and reduced malondialdehyde(MDA)content.Pathological observations indicated that WEG protected against damage to brain in D-gal-induced aging mice.These results effectively revealed that WEG not only improved the abilities of learning and memory,and the cognitive impairment,but also delayed the aging process of the D-gal-induced mice.展开更多
我国高校教学建筑的供暖能耗普遍较高.基于间歇供暖模式对高校课程安排进行优化,是通过改变不同教室的使用规律来降低教学楼整体能耗的有效方法.但仅以建筑节能为目的,而忽略课程授课节次的时间间隔应尽量均匀这一常规排课优化目标,会...我国高校教学建筑的供暖能耗普遍较高.基于间歇供暖模式对高校课程安排进行优化,是通过改变不同教室的使用规律来降低教学楼整体能耗的有效方法.但仅以建筑节能为目的,而忽略课程授课节次的时间间隔应尽量均匀这一常规排课优化目标,会导致优化后的课程安排出现难以与学生客观学习规律相适应的不利结果.为解决以上问题,本研究提出了间歇供暖模式下,同时考虑建筑节能和课程授课时间间隔的高校教学建筑多目标排课优化方法,通过Building Controls Virtual Test Bed(BCVTB)平台建立EnergyPlus与Matlab的联合仿真模型,并利用遗传算法在不同权重的优化目标下对高校排课问题进行计算求解.研究结果表明,随着建筑节能目标所占权重的逐渐增大,排课优化结果存在如下规律:(1)室外温度整体较低的授课日内所排课程减少,室外温度整体较高的授课日内所排课程增多;(2)所有教室中全天不供暖次数以及仅下午供暖的累计次数明显增多;(3)教室占用在时间上逐渐集中,一个教室在半天内课程安排全满的概率显著增加;(4)教学建筑典型周内累计供热量最多可降低31.1%.展开更多
免疫球蛋白相关性疾病(immunoglobulin G4- related diseases,IgG4- RD)可累及全身各个器官,累及甲状腺者称为IgG4相关性甲状腺疾病(IgG4- related thyroid disease,IgG4- RTD)。其临床特点为受累器官弥漫性或局灶性肿大、硬化,血清IgG...免疫球蛋白相关性疾病(immunoglobulin G4- related diseases,IgG4- RD)可累及全身各个器官,累及甲状腺者称为IgG4相关性甲状腺疾病(IgG4- related thyroid disease,IgG4- RTD)。其临床特点为受累器官弥漫性或局灶性肿大、硬化,血清IgG4升高。部分IgG4- RD可导致器官衰竭,特别是胰腺、肝脏和胆道、肾脏、甲状腺、肺和主动脉等。IgG4- RTD多表现为甲状腺局部结节或弥漫性肿大,多伴有血清IgG4升高。IgG4- RTD目前病因未明,多认为与遗传因素、病毒感染、抗原抗体反应有关,治疗上绝大多数对糖皮质激素治疗有效。本文概述了近年来IgG4相关性甲状腺疾病的研究进展。展开更多
文摘帕金森病(Parkinson's disease,PD)是以运动迟缓、肌强直、静止性震颤和姿势步态异常为特征的神经退行性疾病。近年来,经颅磁刺激(Transcranial magnetic stimulation,TMS)在PD运动障碍的诊治中取得了一定进展,不仅为PD的临床诊断提供了一种检测方法,且其重复模式即重复经颅磁刺激(Repetitive transcranial magnetic stimulation,rTMS)对帕金森病的运动症状也显示出积极的治疗前景。本文就rTMS技术在PD运动障碍中的作用原理、分子机制及临床研究现状进行综述。
基金funded by Zhongyuan Scholars in Henan Province(192101510004)Major Science and Technology Projects for Public Welfare of Henan Province(201300110300)+2 种基金Innovation Demonstration Special Project of Henan Province(201111110100)financially supported by Key Project Foundation of Natural Science Research of Universities of Henan Province in China(20A550004)Fundamental Research Funds for the Henan Provincial Colleges and Universities in Henan University of Technology(HAUT)and High-Level Talents Research Fund of HAUT(2018QNJH13,and 2018BS012)。
文摘Wheat embryo globulin(WEG)has been proven to possess multiple biological activities,including antioxidative properties,immunomodulatory,and so on.Aged mouse model were established by subcutaneous injection of D-galactose(D-gal),and the effects of WEG on learning,memory,and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities determination.Compared with the Model group,WEG improved the percentage of the platform quadrant,increased the number of crossing platforms,and enhanced the identification indexs.WEG also increased total antioxidant capacity(T-AOC),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activities in the liver and brains of aging mice,and reduced malondialdehyde(MDA)content.Pathological observations indicated that WEG protected against damage to brain in D-gal-induced aging mice.These results effectively revealed that WEG not only improved the abilities of learning and memory,and the cognitive impairment,but also delayed the aging process of the D-gal-induced mice.
文摘我国高校教学建筑的供暖能耗普遍较高.基于间歇供暖模式对高校课程安排进行优化,是通过改变不同教室的使用规律来降低教学楼整体能耗的有效方法.但仅以建筑节能为目的,而忽略课程授课节次的时间间隔应尽量均匀这一常规排课优化目标,会导致优化后的课程安排出现难以与学生客观学习规律相适应的不利结果.为解决以上问题,本研究提出了间歇供暖模式下,同时考虑建筑节能和课程授课时间间隔的高校教学建筑多目标排课优化方法,通过Building Controls Virtual Test Bed(BCVTB)平台建立EnergyPlus与Matlab的联合仿真模型,并利用遗传算法在不同权重的优化目标下对高校排课问题进行计算求解.研究结果表明,随着建筑节能目标所占权重的逐渐增大,排课优化结果存在如下规律:(1)室外温度整体较低的授课日内所排课程减少,室外温度整体较高的授课日内所排课程增多;(2)所有教室中全天不供暖次数以及仅下午供暖的累计次数明显增多;(3)教室占用在时间上逐渐集中,一个教室在半天内课程安排全满的概率显著增加;(4)教学建筑典型周内累计供热量最多可降低31.1%.
