ATP binding cassette subfamily C member 8(ABCC8)encodes a protein regulating the ATP-sensitive potassium channel.Whether the level of ABCC8 mRNA in lower grade glioma(LGG)correlates with immune cell infiltration and p...ATP binding cassette subfamily C member 8(ABCC8)encodes a protein regulating the ATP-sensitive potassium channel.Whether the level of ABCC8 mRNA in lower grade glioma(LGG)correlates with immune cell infiltration and patient outcomes has not been evaluated until now.Comparisons of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available datasets.The association between ABCC8 and tumor immune cell infiltration,diverse gene mutation characteristics,tumor mutation burden(TMB),and survival in LGG was also investigated in several independent datasets.Pathway enrichment analysis was conducted to search for ABCC8-associated signaling pathways.Through an online database,we found that ABCC8 expression in LGG was lower than in normal tissues.Then,the association of ABCC8 expression and immune cell infiltration in LGG was discussed.As we expected,the ABCC8 mRNA levels were negatively associated with non-T immune cell infiltration levels in all datasets.Consistently,TCGA_LGG RNA-seq data revealed that ABCC8 downregulated several non-T immune cell-associated signaling pathways in gene set enrichment analysis.Different ABCC8 expression groups showed diverse gene mutation characteristics and TMB.The high expression of ABCC8 was linked to improved survival of LGG patients.A pathway enrichment analysis of ABCC8-associated genes indicated that the GABAergic synapse signaling pathway might be involved in regulating immunity in LGG.Our findings show that ABCC8 reflects LGG tumor immunity and is an ideal prognostic biomarker for LGG.展开更多
<strong>Purpose:</strong> The aim of the present study was to determine the degree of using floss and the demographic characteristics of medical faculties of Inner Mongolia Medical University. <strong&g...<strong>Purpose:</strong> The aim of the present study was to determine the degree of using floss and the demographic characteristics of medical faculties of Inner Mongolia Medical University. <strong>Materials and Methods:</strong> Participants completed the questionnaire in the classroom. These participants came from the medical faculties of Chinese Medicine and Western Medicine. These participants were interviewed to determine the demographic characteristics. Non-flossors responded according to their reasons for not flossing. <strong>Results:</strong> A total of 3481 effective data were available for analysis. The floss prevalence was 17.21%, which was lower by 5.72% for students living in rural areas, when compared to students living in urban areas. The largest proportion of non-flossing participants in rural areas answered, “I do not know what a floss is”, while participants in urban answered, “I do not want to use it”. The largest proportion of answered flossing frequency was less than once a month. <strong>Conclusion:</strong> The present study indicates that the prevalence of using floss in medical faculties in Inner Mongolia Medical University was higher, when compared to that in Sichuan province, China, but lower than that in other countries. Although the students use floss, more than one-third of students use floss less than once a month, which is close to “never”. The prevalence in rural areas is lower than those in urban areas. Male not only comprises the total number of prevalence, but also has a frequency greater than that in females. The emphasis on using floss should be improved in medical students.展开更多
Summary:In late December 2019,COVID-19 was firstly recognized in Wuhan,China and spread rapidly to all of the provinces of China.The West Campus of Wuhan Union Hospital,the designated hospital to admit and treat the s...Summary:In late December 2019,COVID-19 was firstly recognized in Wuhan,China and spread rapidly to all of the provinces of China.The West Campus of Wuhan Union Hospital,the designated hospital to admit and treat the severe and critically ill COVID-19 cases,has treated a large number of such patients with great success and obtained lots of valuable experiences based on the Chinese guideline(V7.0).To standardize and share the treatment procedures of severe and critically ill cases,Wuhan Union Hospital has established a working group and formulated an operational recommendation,including the monitoring,early warning indicators,and several treatment principles for severe and critically ill cases.The treatment experiences may provide some constructive suggestions for treating the severe and critically ill COVID-19 cases all over the world.展开更多
Antimony sulfide(Sb_(2)S_(3))is a promising anode for lithium-ion batteries due to its high capacity and vast reserves.However,the low electronic conductivity and severe volume change during cycling hinder its commerc...Antimony sulfide(Sb_(2)S_(3))is a promising anode for lithium-ion batteries due to its high capacity and vast reserves.However,the low electronic conductivity and severe volume change during cycling hinder its commercialization.Herein our work,a three-dimensional(3D)Sb_(2)S_(3) thin film anode was fabricated via a simple vapor transport deposition system by using natural stibnite as raw material and stainless steel fiber-foil(SSF)as 3D current collector,and a carbon nanotube interphase was introduced onto the film surface by a simple dropping-heating process to promote the electrochemical performances.This 3D structure can greatly improve the initial coulombic efficiency to a record of 86.6% and high reversible rate capacity of 760.8 mAh·g^(-1) at 10 C.With carbon nanotubes interphase modified,the Sb_(2)S_(3) anode cycled extremely stable with high capacity retention of 94.7% after 160 cycles.This work sheds light on the economical preparation and performance optimization of Sb_(2)S_(3)-based anodes.展开更多
To deal with the expected diversification on traffic types, the fundamental waveform of the upcoming5 G standard must be sufficiently flexible. In the 4th generation wireless networks(e.g., cellular LTE and Wi- Fi802....To deal with the expected diversification on traffic types, the fundamental waveform of the upcoming5 G standard must be sufficiently flexible. In the 4th generation wireless networks(e.g., cellular LTE and Wi- Fi802.11ac), orthogonal frequency division multiplexing(OFDM) has been widely adopted to combat frequency selectivity and thus improve the spectrum efficiency. Holding various advantages such as backward compatibility with LTE, ease of hardware implementation, time-localized low-latency transmission and straightforward combination with multi-antenna transmission, OFDM will remain as an important waveform candidate for 5G. However,OFDM alone appears to be insufficient in terms of the requirements faced by 5G waveform, such as high flexibility to accommodate different waveform numerologies for an efficient support of diversified traffic types and channel characteristics. In this work, we present a new waveform format, named as filtered-OFDM(f-OFDM) and illustrate its potential and benefits for serving as the underlying waveform of 5G.展开更多
Background:Cytokine receptor-like factor 2(CRLF2)has been shown to play a role in the pathogenesis of acute lymphoblastic leukemia(ALL).Studies have examined the relationship between CRLF2 alterations such as over-exp...Background:Cytokine receptor-like factor 2(CRLF2)has been shown to play a role in the pathogenesis of acute lymphoblastic leukemia(ALL).Studies have examined the relationship between CRLF2 alterations such as over-expression or deregulation and clinical outcome in childhood ALL,but the results are conflicting.This metaanalysis aimed to explore the association between CRLF2 alterations and survival of pediatric patients with ALL.Methods:Electronic databases updated to March 2014 were searched for relevant studies.A meta-analysis was made of twelve studies including 5945 patients to evaluate the prognostic significance of CRLF2 alterations on survival in childhood ALL.Hazards ratios(HRs)with 95%confidence intervals(CIs)were pooled across the studies using a fixed-effects model.Results:CRLF2 over-expression in childhood ALL was associated with poor prognosis in terms of relapse-free survival(RFS;HR=1.70,95%CI=1.28-2.24,P=0.000),event-free survival(EFS;HR=1.78,95%CI=1.05-3.01,R=0.032),and overall survival(OS;HR=2.28,95%CI=1.42-3.65,R=0.001).The combined data also suggested that CRLF2 deregulation in childhood ALL was correlated with poor EFS(HR=1.95,95%CI=1.46-2.61,R=0.000),RFS(HR=2.20,95%CI=1.53-3.18,P=0.000),and OS(HR=1.89,95%CI=1.24-2.87,P=0.003).Subgroup analysis on multivariate HRs showed that CRLF2 deregulation independently predicted a poor prognosis for childhood ALL.Conclusions:The present meta-analysis reveals that both CRLF2 over-expression and deregulation are associated with poor prognosis in pediatric patients with ALL.展开更多
The natural gas vehicle market is rapidly developing throughout the world, and the majority of such vehicles operate on compressed natural gas （CNG）. However, most studies on the emission characteristics of CNG vehi...The natural gas vehicle market is rapidly developing throughout the world, and the majority of such vehicles operate on compressed natural gas （CNG）. However, most studies on the emission characteristics of CNG vehicles rely on laboratory chassis dynamometer measurements, which do not accurately represent actual road driving conditions. To further investigate the emission characteristics of CNG vehicles, two CNG city buses and two CNG coaches were tested on public urban roads and highway sections. Our results show that when speeds of 0-10 km/hr were increased to 10-20 km/hr, the CO2, CO, nitrogen oxide （NOx）, and total hydrocarbon （THC） emission factors decreased by （71.6 ± 4.3）%, （65.6 ± 9.5）%, （64.9± 9.2）% and （67.8 ± 0.3）%, respectively. In this study, The Beijing city buses with stricter emission standards （Euro IV） did not have lower emission factors than the Chongqing coaches with Euro II emission standards. Both the higher emission factors at 0-10 km/hr speeds and the higher percentage of driving in the low-speed regime during the entire road cycle may have contributed to the higher CO2 and CO emission factors of these city buses. Additionally, compared with the emission factors produced in the urban road tests, the CO emission factors of the CNG buses in highway tests decreased the most （by 83.2%）, followed by the THC emission factors, which decreased by 67.1%.展开更多
In this study we conduct firm-level analysis of the impact of women in the boardroom on corporate philanthropic disaster response(CPDR).We propose that CPDR contains agency costs and that female directors are more lik...In this study we conduct firm-level analysis of the impact of women in the boardroom on corporate philanthropic disaster response(CPDR).We propose that CPDR contains agency costs and that female directors are more likely to restrain the associated agency costs of CPDR.We predict a negative relationship between the ratio of women on boards of directors(WoBs) and philanthropic contribution,which is weaker in firms with political connections and stronger in firms with better-developed institutional environments.Data was collected from the philanthropic responses to the Wenchuan earthquake on May 12,2008 of privately-owned listed Chinese firms.The results support the hypothesized negative relationship,which is found to be weaker in firms with political connections.However,marketization-related factors do not significantly moderate this relationship.These results indicate that CPDR contains agency costs and that female directors do not facilitate the corporate donation process,but rather evaluate the benefits and restrain the associated agency costs.展开更多
基金This work was supported by the Scientific and Technological Innovation Program for Clinical Medicine of Jinan(202019132)to LIPING GONG.
文摘ATP binding cassette subfamily C member 8(ABCC8)encodes a protein regulating the ATP-sensitive potassium channel.Whether the level of ABCC8 mRNA in lower grade glioma(LGG)correlates with immune cell infiltration and patient outcomes has not been evaluated until now.Comparisons of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available datasets.The association between ABCC8 and tumor immune cell infiltration,diverse gene mutation characteristics,tumor mutation burden(TMB),and survival in LGG was also investigated in several independent datasets.Pathway enrichment analysis was conducted to search for ABCC8-associated signaling pathways.Through an online database,we found that ABCC8 expression in LGG was lower than in normal tissues.Then,the association of ABCC8 expression and immune cell infiltration in LGG was discussed.As we expected,the ABCC8 mRNA levels were negatively associated with non-T immune cell infiltration levels in all datasets.Consistently,TCGA_LGG RNA-seq data revealed that ABCC8 downregulated several non-T immune cell-associated signaling pathways in gene set enrichment analysis.Different ABCC8 expression groups showed diverse gene mutation characteristics and TMB.The high expression of ABCC8 was linked to improved survival of LGG patients.A pathway enrichment analysis of ABCC8-associated genes indicated that the GABAergic synapse signaling pathway might be involved in regulating immunity in LGG.Our findings show that ABCC8 reflects LGG tumor immunity and is an ideal prognostic biomarker for LGG.
文摘<strong>Purpose:</strong> The aim of the present study was to determine the degree of using floss and the demographic characteristics of medical faculties of Inner Mongolia Medical University. <strong>Materials and Methods:</strong> Participants completed the questionnaire in the classroom. These participants came from the medical faculties of Chinese Medicine and Western Medicine. These participants were interviewed to determine the demographic characteristics. Non-flossors responded according to their reasons for not flossing. <strong>Results:</strong> A total of 3481 effective data were available for analysis. The floss prevalence was 17.21%, which was lower by 5.72% for students living in rural areas, when compared to students living in urban areas. The largest proportion of non-flossing participants in rural areas answered, “I do not know what a floss is”, while participants in urban answered, “I do not want to use it”. The largest proportion of answered flossing frequency was less than once a month. <strong>Conclusion:</strong> The present study indicates that the prevalence of using floss in medical faculties in Inner Mongolia Medical University was higher, when compared to that in Sichuan province, China, but lower than that in other countries. Although the students use floss, more than one-third of students use floss less than once a month, which is close to “never”. The prevalence in rural areas is lower than those in urban areas. Male not only comprises the total number of prevalence, but also has a frequency greater than that in females. The emphasis on using floss should be improved in medical students.
基金Project(51674298)supported by the National Natural Science Foundation of ChinaProject supported by Anhui Province Research and Development Innovation Program,China。
文摘采用硫酸肼作为锂、镍、钴和锰从废锂离子电池中浸出时的还原剂,结合条件实验对浸出机理和浸出动力学进行研究。在最优条件:硫酸2.0 mol/L、硫酸肼30 g/L、固液比50 g/L、温度80℃和浸出时间60 min下,97%的Li、96%的Ni、95%的Co以及86%的Mn被浸出。通过浸出动力学分析得出Li、Ni以及Co的浸出活化能分别为44.32、59.37和55.62 k J/mol,表明浸出过程受化学反应控制。XRD和SEM-EDS分析结果表明,浸出渣的主要组成为MnO2。上述研究结果表明,硫酸肼可作为废锂离子电池中有价金属浸出的有效还原剂。
基金The work was supported by COVID-19 Emergency Scientific Research Project of Science and Technology Department,Hubei Province(No.2020FCA041).
文摘Summary:In late December 2019,COVID-19 was firstly recognized in Wuhan,China and spread rapidly to all of the provinces of China.The West Campus of Wuhan Union Hospital,the designated hospital to admit and treat the severe and critically ill COVID-19 cases,has treated a large number of such patients with great success and obtained lots of valuable experiences based on the Chinese guideline(V7.0).To standardize and share the treatment procedures of severe and critically ill cases,Wuhan Union Hospital has established a working group and formulated an operational recommendation,including the monitoring,early warning indicators,and several treatment principles for severe and critically ill cases.The treatment experiences may provide some constructive suggestions for treating the severe and critically ill COVID-19 cases all over the world.
基金financially supported by the National Natural Science Foundation of China(No.51774343).
文摘Antimony sulfide(Sb_(2)S_(3))is a promising anode for lithium-ion batteries due to its high capacity and vast reserves.However,the low electronic conductivity and severe volume change during cycling hinder its commercialization.Herein our work,a three-dimensional(3D)Sb_(2)S_(3) thin film anode was fabricated via a simple vapor transport deposition system by using natural stibnite as raw material and stainless steel fiber-foil(SSF)as 3D current collector,and a carbon nanotube interphase was introduced onto the film surface by a simple dropping-heating process to promote the electrochemical performances.This 3D structure can greatly improve the initial coulombic efficiency to a record of 86.6% and high reversible rate capacity of 760.8 mAh·g^(-1) at 10 C.With carbon nanotubes interphase modified,the Sb_(2)S_(3) anode cycled extremely stable with high capacity retention of 94.7% after 160 cycles.This work sheds light on the economical preparation and performance optimization of Sb_(2)S_(3)-based anodes.
文摘To deal with the expected diversification on traffic types, the fundamental waveform of the upcoming5 G standard must be sufficiently flexible. In the 4th generation wireless networks(e.g., cellular LTE and Wi- Fi802.11ac), orthogonal frequency division multiplexing(OFDM) has been widely adopted to combat frequency selectivity and thus improve the spectrum efficiency. Holding various advantages such as backward compatibility with LTE, ease of hardware implementation, time-localized low-latency transmission and straightforward combination with multi-antenna transmission, OFDM will remain as an important waveform candidate for 5G. However,OFDM alone appears to be insufficient in terms of the requirements faced by 5G waveform, such as high flexibility to accommodate different waveform numerologies for an efficient support of diversified traffic types and channel characteristics. In this work, we present a new waveform format, named as filtered-OFDM(f-OFDM) and illustrate its potential and benefits for serving as the underlying waveform of 5G.
基金supported in part by grants from the National Natural Science Foundation of China(30971283,81170502)the Zhejiang Provincial Natural Science Foundation of China(LZ12H08001)the Health and Family Planning Commission of Zhejiang Province.
文摘Background:Cytokine receptor-like factor 2(CRLF2)has been shown to play a role in the pathogenesis of acute lymphoblastic leukemia(ALL).Studies have examined the relationship between CRLF2 alterations such as over-expression or deregulation and clinical outcome in childhood ALL,but the results are conflicting.This metaanalysis aimed to explore the association between CRLF2 alterations and survival of pediatric patients with ALL.Methods:Electronic databases updated to March 2014 were searched for relevant studies.A meta-analysis was made of twelve studies including 5945 patients to evaluate the prognostic significance of CRLF2 alterations on survival in childhood ALL.Hazards ratios(HRs)with 95%confidence intervals(CIs)were pooled across the studies using a fixed-effects model.Results:CRLF2 over-expression in childhood ALL was associated with poor prognosis in terms of relapse-free survival(RFS;HR=1.70,95%CI=1.28-2.24,P=0.000),event-free survival(EFS;HR=1.78,95%CI=1.05-3.01,R=0.032),and overall survival(OS;HR=2.28,95%CI=1.42-3.65,R=0.001).The combined data also suggested that CRLF2 deregulation in childhood ALL was correlated with poor EFS(HR=1.95,95%CI=1.46-2.61,R=0.000),RFS(HR=2.20,95%CI=1.53-3.18,P=0.000),and OS(HR=1.89,95%CI=1.24-2.87,P=0.003).Subgroup analysis on multivariate HRs showed that CRLF2 deregulation independently predicted a poor prognosis for childhood ALL.Conclusions:The present meta-analysis reveals that both CRLF2 over-expression and deregulation are associated with poor prognosis in pediatric patients with ALL.
基金supported by the Environmental Public Welfare Project (No. 201209002)
文摘The natural gas vehicle market is rapidly developing throughout the world, and the majority of such vehicles operate on compressed natural gas （CNG）. However, most studies on the emission characteristics of CNG vehicles rely on laboratory chassis dynamometer measurements, which do not accurately represent actual road driving conditions. To further investigate the emission characteristics of CNG vehicles, two CNG city buses and two CNG coaches were tested on public urban roads and highway sections. Our results show that when speeds of 0-10 km/hr were increased to 10-20 km/hr, the CO2, CO, nitrogen oxide （NOx）, and total hydrocarbon （THC） emission factors decreased by （71.6 ± 4.3）%, （65.6 ± 9.5）%, （64.9± 9.2）% and （67.8 ± 0.3）%, respectively. In this study, The Beijing city buses with stricter emission standards （Euro IV） did not have lower emission factors than the Chongqing coaches with Euro II emission standards. Both the higher emission factors at 0-10 km/hr speeds and the higher percentage of driving in the low-speed regime during the entire road cycle may have contributed to the higher CO2 and CO emission factors of these city buses. Additionally, compared with the emission factors produced in the urban road tests, the CO emission factors of the CNG buses in highway tests decreased the most （by 83.2%）, followed by the THC emission factors, which decreased by 67.1%.
基金funded by grants from the National Natural Science Foundation of China(Nos.71002049and 70902066)the New Teacher Fund of the Chinese Ministry of Education(Nos.20106102120055 and20090201120038)+1 种基金the Social Science Promotion Program at Northwestern Polytechnical Universitythe New Teacher Support Program and President's Fund at Xi'an Jiaotong University
文摘In this study we conduct firm-level analysis of the impact of women in the boardroom on corporate philanthropic disaster response(CPDR).We propose that CPDR contains agency costs and that female directors are more likely to restrain the associated agency costs of CPDR.We predict a negative relationship between the ratio of women on boards of directors(WoBs) and philanthropic contribution,which is weaker in firms with political connections and stronger in firms with better-developed institutional environments.Data was collected from the philanthropic responses to the Wenchuan earthquake on May 12,2008 of privately-owned listed Chinese firms.The results support the hypothesized negative relationship,which is found to be weaker in firms with political connections.However,marketization-related factors do not significantly moderate this relationship.These results indicate that CPDR contains agency costs and that female directors do not facilitate the corporate donation process,but rather evaluate the benefits and restrain the associated agency costs.
