Electric field dependence of spin qubit in a Si-MOS quantum dot

Valley, the intrinsic feature of silicon, is an inescapable subject in silicon-based quantum computing. At the spin–valley hotspot, both Rabi frequency and state relaxation rate are significantly enhanced. With protection against charge noise, the valley degree of freedom is also conceived to encode a qubit to realize noise-resistant quantum computing.Here, based on the spin qubit composed of one or three electrons, we characterize the intrinsic properties of valley in an isotopically enriched silicon quantum dot(QD) device. For one-electron qubit, we measure two electric-dipole spin resonance(EDSR) signals which are attributed to partial occupation of two valley states. The resonance frequencies of two EDSR signals have opposite electric field dependences. Moreover, we characterize the electric field dependence of the upper valley state based on three-electron qubit experiments. The difference of electric field dependences of the two valleys is 52.02 MHz/V, which is beneficial for tuning qubit frequency to meet different experimental requirements. As an extension of electrical control spin qubits, the opposite electric field dependence is crucial for qubit addressability,individual single-qubit control and two-qubit gate approaches in scalable quantum computing.

Threshold-independent method for single-shot readout of spin qubits in semiconductor quantum dots

The single-shot readout data process is essential for the realization of high-fidelity qubits and fault-tolerant quantum algorithms in semiconductor quantum dots. However, the fidelity and visibility of the readout process are sensitive to the choice of the thresholds and limited by the experimental hardware. By demonstrating the linear dependence between the measured spin state probabilities and readout visibilities along with dark counts, we describe an alternative threshold-independent method for the single-shot readout of spin qubits in semiconductor quantum dots. We can obtain the extrapolated spin state probabilities of the prepared probabilities of the excited spin state through the threshold-independent method. We then analyze the corresponding errors of the method, finding that errors of the extrapolated probabilities cannot be neglected with no constraints on the readout time and threshold voltage. Therefore, by limiting the readout time and threshold voltage, we ensure the accuracy of the extrapolated probability. We then prove that the efficiency and robustness of this method are 60 times larger than those of the most commonly used method. Moreover, we discuss the influence of the electron temperature on the effective area with a fixed external magnetic field and provide a preliminary demonstration for a single-shot readout of up to 0.7K/1.5T in the future.

Diagnosis and therapy of tacrolimus toxicity in a liver transplant recipient during COVID-19 treatment

To the Editor:SARS-CoV-2,the pathogen responsible for the pandemic of coronavirus disease 2019(COVID-19),has had profound impacts on human health,and its antagonist Paxlovid is a commonly used treatment option[1].However,treatment selection for immunosuppressed patients,such as liver recipients,remains uncertain due to potential drug interactions and the risk of immunosuppressant dosage adjustment,which can cause liver injury[2].

Reconstruction of Paprosky type ⅢB acetabular bone defects using a cup-on-cup technique: A surgical technique and case series

BACKGROUND Paprosky type ⅢB acetabular bone defects are very difficult to reconstruct.For severe defects,we developed our own cup-on-cup technique.We defined the tantalum metal (TM) revision shell with the peripheral titanium ring removed as a TM-cup augment and the cementless hemispherical acetabulum component combined with a TM-cup augment as the cup-on-cup technique.AIM To report the short-term results of patients with typeⅢB acetabular bone defects reconstructed using the cup-on-cup technique.METHODS We retrospectively reviewed six patients (six hips) with a mean age of 59 years who underwent acetabular reconstruction using our cup-on-cup technique between January 2015 and January 2017.All acetabular bone defects were classified as typeⅢB without pelvic discontinuity using the system of Paprosky All patients were followed both clinically and radiographically for a mean duration of 42 mo.RESULTS The mean Harris hip score improved from 32.4 pre-operatively to 80.7 at the last follow-up.The mean vertical position of the hip rotation centre changed from60.9 mm pre-operatively to 31.7 mm post-operatively,and the mean horizontal position changed from 33.6 mm pre-operatively to 38.9 mm post-operatively.Greater trochanteric migration after extended trochanteric osteotomy occurred in one of six hips at 3 mo.There was no evidence of component migration at the last follow-up.CONCLUSION The short-term results suggest that our cup-on-cup technique could beconsidered an effective management option for Paprosky type ⅢB acetabular bone defects without pelvic discontinuity.

基于有限突变模型和大规模数据的19个常染色体STR的实际突变率研究

短串联重复序列(short tandem repeat,STR)已广泛用于法医学亲子鉴定和个体识别中,但STR的突变可能会影响其结果的解释。在大多数类似研究中,由于忽略“隐性”突变现象,STR的突变率被低估。鉴于此,为获得更加准确的STR实际突变率,本研究使用Slooten与Ricciardi提出的有限突变模型和大规模数据,对28,313例(78,739个体)中国北京汉族已确认亲生关系的亲子鉴定案的20个常染色体STR基因座(D3S1358、D1S1656、D13S317、Penta E、D16S539、D18S51、D2S1338、CSF1PO、Penta D、TH01、vWA、D21S11、D6S1043、D7S820、D5S818、TPOX、D8S1179、D12S391、D19S433和FGA;由于有限突变模型中未包含D6S1043的矫正参数,因此本文实际计算其余19个STR基因座的突变率)进行了调查。结果发现,所有基因座均存在突变现象,总计发生1665个突变事件,包括1614个一步突变,34个两步突变,8个三步突变和9个非整步突变。基因座特异性的平均实际突变率在三联体中为0.00007700(TPOX)~0.00459050(FGA),在二联体中为0.00000000(TPOX)~0.00344850(FGA)。此外,本研究还分析了表面和实际突变率、三联体和二联体突变率、父源和母源的突变率之间的关系。研究表明,实际突变率多大于表面突变率,而且μ1^(*)/μ2^(*)(表面突变率)的比值通常也大于μ1/μ2(实际突变率)(μ1^(*),μ1;μ2^(*),μ2分别是一步和两步的突变率),即更多的“隐性”突变被释放出来。而且父源和母源的三联体和二联体的突变率也有存在差异。随后,将这些突变率数据与已发表的中国其他汉族人口的相关研究进行比较,展现出了STR突变率的时间与区域差异。由于样本量大,本研究中还报告了一些少见的突变事件,例如同卵双胞胎突变和“假四步突变”等。综上所述,本研究通过大量数据获得了接近真实的STR突变率的估计值,不仅可为中国法医DNA数据库和群体遗传学数据库提供重要的基础数据,也对开展法医学个体识别、亲权鉴定和遗传学研究具有重要的意义。

硫酸镁与硝苯地平对妊娠期高血压疾病孕妇血流动力学和妊娠结局的影响比较

目的比较硫酸镁与硝苯地平对妊娠期高血压疾病(HDCP)孕妇血流动力学和妊娠结局的影响。方法选取114例HDCP孕妇作为研究对象,按照随机数字表法分为观察组(给予硝苯地平治疗)与对照组(给予硫酸镁治疗),每组57例。检测2组孕妇全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)、抗心磷脂抗体免疫球蛋白G(ACA-IgG)和抗心磷脂抗体免疫球蛋白M(ACA-IgM)水平,并观察2组孕妇的不良反应、妊娠结局。结果治疗前,2组HBV、LBV、PV、ACA-IgG和ACA-IgM水平比较,差异无统计学意义(P>0.05);治疗后,2组HBV、LBV、PV、ACA-IgG和ACA-IgM水平均低于治疗前,且观察组HBV、LBV、PV、ACA-IgG和ACA-IgM水平均低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率为7.02%,与对照组不良反应总发生率5.26%相比,差异无统计学意义(P>0.05)。观察组早产率、新生儿窒息率、剖宫产率分别为10.53%、3.51%、22.81%,低于对照组的31.58%、21.05%、43.86%,差异有统计学意义(P<0.05)。结论硫酸镁与硝苯地平治疗HDCP均能起到改善血流动力学和妊娠结局的效果,但硝苯地平改善效果更佳。

^(18)F-fluorodeoxyglucose PET/CT findings of a solitary primary hepatic lymphoma:A case report

Primary hepatic lymphoma is extremely rare,and only a few cases have been described on positron emission tomography(PET) or PET/computed tomography(PET/CT) imaging in the English literature.We report a case of a 55-year-old woman who presented with low-grade fever and weight loss of three months.On CT scanning,a mass was identified which appeared to be a hypoattenuating lesion,on ultrasonographic imaging,the mass was hypoechoic,therefore,liver abscess or hepatic metastasis from a gastrointestinal primary was initially suspected.Tumor markers such as alpha-fetoprotein,carcinoembryonic antigen and carbohydrate antigen 19-9 were within normal limits.PET/CT demonstrated a large abnormal ring-like hypermetabolic focus in the right liver lobe.The lesion was resected and the histo-pathological findings were consistent with lymphoma.The patient was discharged two weeks after surgery and did not receive any further treatment.After 25 mo follow-up,she is in good health.18F-fluorodeoxyglucose PET/CT is useful in confirming the diagnosis of primary hepatic lymphoma by demonstrating no other foci with high uptake in other parts of the body.

血清干扰素-γ、淀粉样蛋白A及可溶性血管内皮生长因子受体-1在原因不明复发性流产患者中的表达及意义

目的探讨血清干扰素-γ(IFN-γ)、血清淀粉样蛋白A(SAA)及可溶性血管内皮生长因子受体-1(sFlt-1)在原因不明复发性流产(URSA)患者中的表达及意义。方法前瞻性选取URSA患者100例为研究组,另选取同期行人工流产的正常早孕妇女60例为对照组。2组均进行血清IFN-γ、SAA及sFlt-1检测。比较2组血清IFN-γ、SAA及sFlt-1表达。采用受试者工作特征(ROC)曲线分析血清IFN-γ、SAA及sFlt-1对URSA的预测价值。结果2组年龄、分娩次数及自然流产次数比较,差异有统计学意义(P<0.05)。研究组血清IFN-γ、SAA及sFlt-1水平高于对照组,差异有统计学意义(P<0.05)。血清IFN-γ与SAA、sFlt-1均呈正相关(r=0.671、0.728,P<0.05);SAA与sFlt-1呈正相关(r=0.708,P<0.05)。年龄、IFN-γ、SAA、sFlt-1为URSA发生的影响因素(P<0.05)。ROC曲线结果显示,血清IFN-γ、SAA及sFlt-1预测URSA的曲线下面积(AUC)为0.877、0.862、0.850;血清IFN-γ预测URSA的敏感度为80.0%、特异度为85.0%,SAA敏感度为78.0%、特异度为88.3%,sFlt-1敏感度为70.0%、特异度90.0%。结论血清IFN-γ、SAA及sFlt-1水平升高为URSA的危险因素,且对URSA具有一定预测价值。

Re-revision surgery for re-recurrent valgus deformity after revision total knee arthroplasty in a patient with a severe valgus deformity: A case report

BACKGROUND A recurrent valgus deformity was a common complication after total knee arthroplasty(TKA)in patients with valgus deformity.However,re-revision surgery for re-recurrent valgus deformity after revision TKA in patients with valgus deformity before primary TKA was uncommon.CASE SUMMARY We reported a 72-year-old female patient with two recurrent valgus deformities after TKA for a valgus knee deformity who underwent two revision surgeries to rectify the deformity.In the re-revision surgery,bone defects were successfully reconstructed by the augments and cement in combination with screws and a sleeve.An appropriate neutral alignment of the lower limb was restored by the perfect femoral entry point and the long diaphyseal cementless stem.Adequate fixation of the metaphysis and diaphysis of the femur was obtained by the sleeve and long diaphyseal cementless stem.The patient was pain-free and deformityfree for 2.5 years.CONCLUSION The management of bone defects,the choice of the stem and the femoral entry point were of vital importance in the revision or re-revision TKA for a recurrent valgus deformity.

Effects of LW-AFC,a new formula derived from Liuwei Dihuang decoction,on intestinal microbiome in senescence-accelerated mouse prone 8 strain,a mouse model of Alzheimer disease

OBJECTIVE To investigate the effects of LW-AFC,a new formula derived fromLiuwei Dihuang decoction,on gut microbiota and the behavior of learning and memory of SAMP8 mice,a mouse model of Alzheimer Disease(AD),and identify the specific intestinal microbiota correlating with cognitive ability.METHODS Morris-water maze test,novel object recognition test and shuttle-box test were conducted to observe the ability of learning and memory.16S rRNA amplicon sequencing(Illumina,San Diego,CA,USA)was employed to investigate gut microbiota.RESULTS The treatment of LW-AFC improved cognitive impairments of SAMP8 mice,including spatial learning and memory ability,active avoidance response,and object recognition memory capability.Our data indicated that there were significantly 8 increased and 12 decreased operational taxonomic units(OTUs)in the gut microbiota of SAMP8 mice compared with senescence accelerated mouse resistant 1(SAMR1) strains,the control of SAMP8 mice.The treatment of LW-AFC altered 22(16 increased and 6 decreased)OTUs in SAMP8 mice and among them,15 OTUs could be reversed by LW-AFC treatment resulting in a microbial composition similar to that of SAMR1 mice.We further showed that there were7(3 negative and 4 positive correlation)OTUs significantly correlated with all the three types of cognitive abilities,at the order level,including Bacteroidales,Clostridiales,Desulfovibrionales,CW040,and two unclassified orders.LW-AFC had influences on bacterial taxa correlated with the abilities of learning and memory in SAMP8 mice and restored them to SAMR1 mice.CONCLUSION The effects of LW-AFC on improving cognitive impairments of SAMP8 mice might be via modulating intestinal microbiome and LW-AFC could be used as a potential anti-AD agent.

Model design and structure research for integration system of energy, information and transportation networks based on ANP-fuzzy comprehensive evaluation

For lack of deep research on model, system structure and top-level design, the integrated system concept of energy, information and transportation networks fails to provide effective guidance for transferring the theory to practice. In this paper, with dispatching of energy flow and information flow as a focus, clean energy of wind power and solar power as carrier, battery charging & swapping station as medium and all kinds of transportation flows as entity, a five-in-one threenetwork integrated system model is built by full use of technologies of Internet of Vehicles(IOV) and Internet of things(IOT) to promote the innovative concept of three-network integration into practice, and provide a reference for future researches.

ON SELF-ABSORPTION CORRECTION IN EXCIMER FLUORESCENCE MEASUREMENTS OF POLYMER SOLUTIONS

The effect of self absorption on the ratio of excimer to monochromophore emission intensities, I-e/I-m, has been explored by experimentally changing the solution layer thickness of the emission light path traversed in the solution in the right-angle geometry. The result shows that data obtained by front-face geometry are better than those obtained by right-angle geometry even after correction to zero solution thickness. The correction formula based on geometric optics given by Tsai and Torkelson is not adequate.

Biomechanical comparison of locking plate and crossing metallic and absorbable screws fixations for intra-articular calcaneal fractures

The locking plate and percutaneous crossing metallic screws and crossing absorbable screws have been used clinically to treat intra-articular calcaneal fractures, but little is known about the biomechanical differences between them. This study compared the biomechanical stability of calcaneal fractures fixed using a locking plate and crossing screws. Three-dimensional finite-element models of intact and fractured calcanei were developed based on the CT images of a cadaveric sample. Surgeries were simulated on models of Sanders type III calcaneal fractures to produce accurate postoperative models fixed by the three implants. A vertical force was applied to the superior surface of the subtalar joint to simulate the stance phase of a walking gait. This model was validated by an in vitro experiment using the same calcaneal sample. The intact calcaneus showed greater stiffness than the fixation models. Of the three fixations, the locking plate produced the greatest stiffness and the highest von Mises stress peak. The micromotion of the fracture fixated with the locking plate was similar to that of the fracture fixated with the metallic screws but smaller than that fixated with the absorbable screws. Fixation with both plate and crossing screws can be used to treat intra-articular calcaneal fractures. In general, fixation with crossing metallic screws is preferable because it provides sufficient stability with less stress shielding.

A security scheme for intelligent substation communications considering real-time performance

Tampering,forgery and theft of the measurement and control messages in a smart grid could cause one breakdown in the power system.However,no security measures are employed for communications in intelligent substations.Communication services in an intelligent substation have high demands for real-time performance,which must be considered when deploying security measures.This paper studies the security requirements of communication services in intelligent substations,analyzes the security capabilities and shortages of IEC 62351,and proposes a novel security scheme for intelligent substation communications.This security scheme covers internal and telecontrol communications,in which the real-time performance of each security measure is considered.In this scheme,certificateless public key cryptography(CLPKC)is used to avoid the latency of certificate exchange in certificate-based cryptosystem and the problem of key escrow in identity-based cryptosystem;the security measures of generic object-oriented substation event,sampled measure value and manufacturing message specification in IEC 62351 are improved to meet the real-time requirements of the messages as well as to provide new security features to resist repudiation and replay attacks;and the security at transport layer is modified to fit CLPKC,which implements mutual authentication by exchanging signatures.Furthermore,a deployment of CLPKC in an intelligent substation is presented.We also evaluate the security properties of the scheme and analyze the end-to-end delays of secured services by combining theoretical calculation and simulation in this paper.The results indicate that the proposed scheme meets the requirements of security and real-time performance of communications in intelligent substations.

Plug-in and plug-out dispatch optimization in microgrid clusters based on flexible communication

With large-scale development of distributed generation(DG) and its potential role in microgrids, the microgrid cluster(MGC) becomes a useful control model to assist the integration of DG. Considering that microgrids in a MGC, power dispatch optimization in a MGC is dif-ficult to achieve. In this paper, a hybrid interactive communication optimization solution(HICOS) is suggested based on flexible communication, which could be used to solve plug-in or plug-out operation states of microgrids in MGC power dispatch optimization. HICOS consists of a hierarchical architecture: the upper layer uses distributed control among multiple microgrids, with no central controller for the MGC, and the lower layer uses a central controller for each microgrid. Based on flexible communication links among microgrids, the optimal iterative information are exchanged among microgrids, thus HICOS would gradually converge to the global optimal solution.While some microgrids plug-in or plug-out, communication links will be changed, so as to unsuccessfully reach optimal solution. Differing from changeless communication links in traditional communication networks, HICOS redefines the topology of flexible communication links to meet the requirement to reach the global optimal solutions.Simulation studies show that HICOS could effectively reach the global optimal dispatch solution with non-MGC center. Especially, facing to microgrids plug-in or plug-out states, HICOS would also reach the global optimal solution based on refined communication link topology.

Defensive Resource Allocation Method for Improving Survivability of Communication and Information System in CPPS Against Cyber-attacks

With the widespread use of communication and information technology,power system has been evolving into cyber-physical power system(CPPS)and becoming more vulnerable to cyber-attacks.Therefore,it is necessary to enhance the ability of the communication and information system in CPPS to defend against cyber-attacks.This paper proposes a method to enhance the survivability of the communication and information system in CPPS.Firstly,the communication and information system for critical business of power system is decomposed into certain types of atomic services,and then the survivability evaluation indexes and their corresponding calculation method for the communication and information system are proposed.Secondly,considering the efficacy and cost defensive resources,a defensive resource allocation model is proposed to maximize the survivability of communication and information system in CPPS.Then,a modified genetic algorithm is adopted to solve the proposed model.Finally,the simulation results of CPPS for an IEEE 30-node system verify the proposed method.

An instrument for methodological quality assessment of single-subject finite element analysis used in computational orthopaedics

The methodological quality of subject-specific finite element analysis papers depends on the rigor of the study design and detailed description of key elements,while assessment instruments are often confined to clinical trials or quasi-experiments.This study aims to present an instrument for methodological quality assessment of singlesubject finite element analysis used in computational orthopaedics(MQSSFE).Based upon existing instruments and relevant review papers,a pilot version was developed consisting of 37 items with 6 domains,including study design and presentation of findings,subject recruitment,model reconstruction and configuration,boundary and loading conditions(simulation),model verification and validation,and model assumption and validity.We interviewed four experts in the field to assess the face validity and refined the instrument.The instrument was tested for interrater reliability among two assessors on nine finite element study papers.Also,the criterion validity was evaluated by comparing the similarity of the MQSSFE and the modified Down and Black instrument.The intraclass correlation coefficient was 0.965,while the MQSSFE was significantly moderately correlated with the modified Down and Black instruments(r=0.61).We believed that MQSSFE was adequately appropriate,reliable,and valid for assessing the methodological quality for finite element studies used in computational orthopaedics.The instrument could facilitate quality assessment in the systematic reviews of finite element models and checklists for fidelity.

Virtual reality based multiple life skill training for intellectual disability:A multicenter randomized controlled trial

Life skill-based training is essential for intellectual disabled individuals to regain autonomy and social inclusion.Virtual reality(VR)could deliver a nascent application that is more engaging and secure.The objective of this study was to evaluate the training effects of the VR-based multiple life skill training program on life skill perfor-mance,self-efficacy,memory,cognitive and behavioral functions via a multicenter randomized controlled trial.A total of 145 intellectual disabled participants were recruited for a randomized controlled trial with three in-tervention arms:VR(n=42);traditional(n=53);and control(n=50).The life skill tasks for the interventions included 1)grocery shopping,2)cooking,and 3)kitchen cleaning.Outcome measures were performance scores for the three tasks,self-efficacy scale,digit span score,and Frontal Assessment Battery score,graded by blinded assessors.Before-after effects of each group were evaluated using separated Wilcoxon Signed-rank tests.VR sig-nificantly improved cooking,cleaning performance,and memory span,while traditional training significantly improved shopping,cooking,and cleaning tasks.The generalized estimating equation evaluated effects between groups adjusted for age,gender and intelligence quotient(IQ).VR had significantly larger improvement effects in cooking and cleaning than the control group and memory span compared to traditional training and controls groups.IQ appeared to be a significant confounder on the training effect.Future work may consider developing artificial intelligence to customize programs depending on IQ level.

探索共同项目负责人模式促进学科交叉融合

共同项目负责人(Multiple-Principal Investigator,M-PI)制度是美国国立卫生研究院(National Institutes of Health,NIH)科研项目的重要特征,目前NIH多种研究类项目已采用M-PI模式。M-PI允许在一个项目中设立多个PI,他们在指导项目完成方面具有同等权力和责任。M-PI项目的评审原则与单一PI项目相同,但需要另外提供一份领导方案,说明选择M-PI模式的理由及不同PI之间合作方案。自2006年实施以来,M-PI项目数量持续增长,有效促进了生物医学领域学科交叉和深度融合,其科学性和合理性已得到广泛认可。国家自然科学基金委员会医学科学部2022年在生命与医学板块专项中试点Co-PI(Co-Principal Investigator)制,有效引导临床与基础学科交叉融合。本文通过分析NIH实施M-PI政策的运行情况和取得的成果,为我国促进学科交叉融合、推动原始创新提供借鉴,为我国科学基金管理制度的改革和完善提供参考。

Distribution Locational Marginal Pricing Based Equilibrium Optimization Strategy for Data Center Park with Spatial-temporal Demand-side Resources

This paper proposes a distribution locational marginal pricing(DLMP) based bi-level Stackelberg game framework between the internet service company(ISC) and distribution system operator(DSO) in the data center park. To minimize electricity costs, the ISC at the upper level dispatches the interactive workloads(IWs) across different data center buildings spatially and schedules the battery energy storage system temporally in response to DLMP. Photovoltaic generation and static var generation provide extra active and reactive power. At the lower level, DSO calculates the DLMP by minimizing the total electricity cost under the two-part tariff policy and ensures that the distribution network is uncongested and bus voltage is within the limit. The equilibrium solution is obtained by converting the bi-level optimization into a single-level mixed-integer second-order cone programming optimization using the strong duality theorem and the binary expansion method. Case studies verify that the proposed method benefits both the DSO and ISC while preserving the privacy of the ISC. By taking into account the uncertainties in IWs and photovoltaic generation, the flexibility of distribution networks is enhanced, which further facilitates the accommodation of more demand-side resources.