Data fusion methods in multimodal human computer dialog

In multimodal human computer dialog,non-verbal channels,such as facial expression,posture,gesture,etc,combined with spoken information,are also important in the procedure of dialogue.Nowadays,in spite of high performance of users*single channel behavior computing,it is still great challenge to understand users1 intention accurately from their multimodal behaviors.One reason for this challenge is that we still need to improve multimodal information fusion in theories,methodologies and practical systems.This paper presents a review of data fusion methods in multimodal human computer dialog.We first introduce the cognitive assumption of single channel processing,and then discuss its implementation methods in human computer dialog;for the task of multi-modal information fusion,serval computing models are presented after we introduce the principle description of multiple data fusion.Finally,some practical examples of multimodal information fusion methods are introduced and the possible and important breakthroughs of the data fusion methods in future multimodal human-computer interaction applications are discussed.

Advances in liver transplantation for unresectable colon cancer liver metastasis

It is estimated that 50%of patients with colorectal cancer will develop liver metastasis.Surgical resection significantly improves survival and provides a chance of cure for patients with colorectal cancer liver metastasis(CRLM).Increasing the resectability of primary unresectable liver metastasis provides more survival benefit for those patients.Considerable surgical innovations have been made to increase the resection rate and decrease the potential risk of hepatic failure postoperation.Liver transplantation(LT)has been explored as a potential curative treatment for unresectable CRLM.However,candidate selection criteria,chemotherapy strategies,refined immunity regimens and resolution for the shortage of grafts are lacking.This manuscript discusses views on surgical indication,peritransplantation anti-tumor and anti-immunity therapy and updated advances in LT for unresectable CRLM.A literature review of published articles and registered clinical trials in PubMed,Google Scholar,and Clinicaltrials.gov was performed to identify studies related to LT for CRLM.Some research topics were identified,including indications for LT for CRLM,oncological risk,antitumor regimens,graft loss,administration of anti-immunity drugs and solutions for graft deficiency.The main candidate selection criteria are good patient performance,good tumor biological behavior and chemosensitivity.Chemotherapy should be administered before transplantation but is not commonly administered posttransplantation for preventive purposes.Mammalian target of rapamycin regimens are recommended for their potential oncological benefit,although there are limited cases.In addition to extended criterion grafts,living donor grafts and small grafts combined with two-stage hepatectomy are efficient means to resolve organ deficiency.LT has been proven to be an effective treatment for selected patients with liver-only CRLM.Due to limited donor grafts,high cost and poorly clarified oncological risks,LT for unresectable CRLM should be strictly performed under a well-organized study plan in selected patients.Some vital factors,like LT indication and anti-tumor and anti-immune treatment,remain to be confirmed.Ongoing clinical trials are expected to delineate these topics.