Evaluation of vascular recanalization rate and nerve injury of mechanical thrombectomy combined with rt-PA thrombolysis in treatment of acute cerebral infarction

Objective:To investigate the vascular recanalization rate of mechanical thrombectomy combined with recombinant tissue-type plasminogen activator (rt-PA) thrombolysis in the treatment of acute cerebral infarction and the effect on the nerve injury in patients.Methods:A total of 90 patients with acute cerebral infarction who were treated in our hospital between January 2016 and January 2019 were retrospectively analyzed and divided into the control group (n=46) receiving rt-PA thrombolysis and the observation group (n=44) receiving mechanical thrombectomy combined with rt-PA thrombolysis. The differences in vascular recanalization rate 24 h after treatment as well as serum levels of inflammatory mediators [interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-7 (IL-7), interleukin-17 (IL-17) and hypersensitive C-reactive protein (hs-CRP)], nerve injury markers [brain-derived neurotrophic factor (BDNF), neuron-specific enolase (NSE) and S100B protein (S100B)] and neurotransmitters [glutamate (Glu) and 5-hydroxytryptamine (5-HT)] before and after treatment were compared between the two groups of patients.Results: 24 h after treatment, the vascular recanalization rate of the observation group was higher than that of the control group (P<0.05). 24 h after treatment and 1 week after treatment, serum IL-1, IL-6, IL-7, IL-17 and hs-CRP levels in the observation group were lower than those in the control group;BDNF level was higher than that in the control group, while NSE and S100B levels were lower than those in the control group;Glu and 5-HT levels were lower than those in the control group (P<0.05). Conclusions: Mechanical thrombectomy combined with rt-PA thrombolysis can increase the early postoperative vascular recanalization rate in patients with acute cerebral infarction, and it also plays an active role in alleviating nerve injury.

三元AGa_(5)S_(8)(A=K,Rb,Cs):通过“一替多取代”策略制备的红外非线性光学材料

目前,商用的红外非线性光学晶体材料,如具有类金刚石结构的硫属化合物AgGaQ_(2)(Q=S,Se),具有强的非线性光学系数.然而,相对较低的抗激光损伤阈值制约了其在高能激光领域的应用.以类金刚石结构的闪锌矿ZnS为模板,我们通过“一替多取代”策略,即[SZn_(4)^(6+)+5Zn^(2+)■A^(+)+5Ga^(3+)](A=K、Rb和Cs),采用固相合成方法,获得了三元晶体AGa_(5)S_(8)(A=K、Rb和Cs).极性结构的AGa_(5)S_(8)保持了类金刚石阴离子骨架框架,非线性光学功能基元GaS4四面体以平行排列的方式堆积,使其具有高的相位匹配倍频强度(1.1–1.2×AgGaS_(2));另外,含有高正电性A+阳离子使其表现出3.10–3.37 eV的宽带隙,进而提高抗激光损伤阈值(9.3–12.4×AgGaS_(2)).晶体AGa_(5)S_(8)(A=K、Rb和Cs)是第一个具有大倍频响应(≥1.0×AgGaS_(2))和宽带隙(≥3.0 eV)的三元含碱金属的硫属化合物,满足了优秀红外非线性光学材料的严格要求.此外,“一替多取代”策略在类金刚石结构演变中具有重要意义,并为获得新非线性光学材料提供了良好的机遇.