The incidence of prostate cancer has increased year by year in the world.Despite improvements in diagnosis,surgical techniques,and drugs,survival rates of prostate cancer have improved little,and most prostate cancer-...The incidence of prostate cancer has increased year by year in the world.Despite improvements in diagnosis,surgical techniques,and drugs,survival rates of prostate cancer have improved little,and most prostate cancer-related deaths are as a result of castration resistant prostate cancer(CRPC),which progresses and metastasizes after surgical or medical castration.The pathogenesis of CRPC is still unclear.It has been found that the majority of CRPC patients have overexpression of androgen receptors(ARs),and there are many forms of changes in the signaling pathways that intersect with them during he process to CRPC.Micro ribonucleic acid(miRNA)plays an important role in regulating the expression and translation of prostate cancer target genes,and in the life cycle of cell cycle distribution and apoptosis.Relatedly,active changes in miRNA expression are also closely related to androgen.Therefore,the study of AR-related signaling pathways and AR and miRNA-related signaling pathways is of great significance in the treatment of CRPC.展开更多
Lung cancer has become a leading cause of cancer-related death because of its high morbidity and mortality.Although some progress has been made in the diagnosis,surgery,chemoradiotherapy,and other aspects of lung canc...Lung cancer has become a leading cause of cancer-related death because of its high morbidity and mortality.Although some progress has been made in the diagnosis,surgery,chemoradiotherapy,and other aspects of lung cancer in the last decade,actually there is no substantial breakthrough for the 5-year survival rate of patients has no significant improvement and is still below 15%.Plenty of evidence suggests that malignant tumors including lung cancer have a unique subgroup of cells featured with self-renewal and multidirectional differentiation potential.Cancer stem cells(CSCs)are the root of tumor growth and metastasis,and the characteristic changes of malignant phenotype(such as recurrence,invasion and metastasis,and drug resistance)are closely linked with CSCs.This paper explored the possible correlated mechanism of the complex interaction between lung cancer stem cells(LCSCs)and lung cancer microenvironment,to provide ideas for the R&D of relevant treatment technologies,the promotion of the progress in traditional medical technology,and the breakthrough of the bottleneck of long-term effect of lung cancer.展开更多
基金This study was funded by the National Natural Science Foundation of China (81603438), the Natural Science Foundation of Tianjin (19JCZDJC37000).
文摘The incidence of prostate cancer has increased year by year in the world.Despite improvements in diagnosis,surgical techniques,and drugs,survival rates of prostate cancer have improved little,and most prostate cancer-related deaths are as a result of castration resistant prostate cancer(CRPC),which progresses and metastasizes after surgical or medical castration.The pathogenesis of CRPC is still unclear.It has been found that the majority of CRPC patients have overexpression of androgen receptors(ARs),and there are many forms of changes in the signaling pathways that intersect with them during he process to CRPC.Micro ribonucleic acid(miRNA)plays an important role in regulating the expression and translation of prostate cancer target genes,and in the life cycle of cell cycle distribution and apoptosis.Relatedly,active changes in miRNA expression are also closely related to androgen.Therefore,the study of AR-related signaling pathways and AR and miRNA-related signaling pathways is of great significance in the treatment of CRPC.
文摘Lung cancer has become a leading cause of cancer-related death because of its high morbidity and mortality.Although some progress has been made in the diagnosis,surgery,chemoradiotherapy,and other aspects of lung cancer in the last decade,actually there is no substantial breakthrough for the 5-year survival rate of patients has no significant improvement and is still below 15%.Plenty of evidence suggests that malignant tumors including lung cancer have a unique subgroup of cells featured with self-renewal and multidirectional differentiation potential.Cancer stem cells(CSCs)are the root of tumor growth and metastasis,and the characteristic changes of malignant phenotype(such as recurrence,invasion and metastasis,and drug resistance)are closely linked with CSCs.This paper explored the possible correlated mechanism of the complex interaction between lung cancer stem cells(LCSCs)and lung cancer microenvironment,to provide ideas for the R&D of relevant treatment technologies,the promotion of the progress in traditional medical technology,and the breakthrough of the bottleneck of long-term effect of lung cancer.
