In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells.Tumor cells mainly adopt the glycolysis as energy source to maintai...In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells.Tumor cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic conditions.Investigation on energy metabolism pathway in cancer cells has aroused the interest of cancer researchers all around the world.In recent years,plentiful studics suggest that targeting the peculiar cancer energy metabolic pathways,including glycolysis,mitochondrial respiration,amino acid metabolism,and fatty acid oxidation may be an effective strategy to starve cancer cells by blocking essential nutrients.Natural products (NPs)are considered as the “treasure trove of small molecules drugs” and have played an extremely remarkable role in the discovery and development of anticancer drugs.And numerous NPs have been reported to act on cancer energy metabolism targets.Herein,a comprehensive overview about cancer energy metabolism targets and their natural-occurring inhibitors is prepared.展开更多
In this paper,a new organic–inorganic hybrid compound[Co(L)_(2)]2[W_(6)O_(19)](1)(HL=2-acetylpyridine thiosemicarbazone)was prepared and characterized.The compound 1 exhibits remarkable antibacterial activity by dete...In this paper,a new organic–inorganic hybrid compound[Co(L)_(2)]2[W_(6)O_(19)](1)(HL=2-acetylpyridine thiosemicarbazone)was prepared and characterized.The compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration(MIC)against Staphylococcus aureus(S.aureus,0.06μg·mL^(−1))and Escherichia coli(E.coli,0.24μg·mL^(−1)),respectively.Furthermore,the potential mechanism of compound 1 was studied in detail.The potential causes of bacteria death were cell wall/membrane disruption,inhibition of intracellular respiratory chain dehydrogenases(RCD)activity,destruction of reactive oxygen species(ROS)and depletion of glutathione(GSH).展开更多
The new coronavirus pneumonia(coronavirus disease 2019[COVID-19]),caused by the new coronavirus(severe acute respiratory syndrome coronavirus 2[SARS-CoV-2]),mainly manifests by fever,dry cough,and fatigue.The emergenc...The new coronavirus pneumonia(coronavirus disease 2019[COVID-19]),caused by the new coronavirus(severe acute respiratory syndrome coronavirus 2[SARS-CoV-2]),mainly manifests by fever,dry cough,and fatigue.The emergence of SARS-CoV-2 poses a huge threat to people’s lives.Unfortunately,so far,there are no effective treatment drugs and vaccines.Traditional Chinese medicine(TCM)has played an important role and achieved good results for treating this epidemic.More than 85%of patients with SARS-CoV-2 infection in China have received TCM treatment.In this article,we describe the progress of TCM for the COVID-19 therapy.展开更多
基金This work was financially supported by grants from the National Natural Science Foundation of China(No.81773594,U1703111,81473254 and 81773637,31270399)Liaoning Revitalization Talents Program(No.XLYC1807182)+2 种基金Program for Liaoning Innovation Talents in University(No.LR2016002)Liaoning Province Natural Science Foundation(No.2019-MS-299)Shenyang Planning Project of Science and Technology(No.18-013-0-46).
文摘In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells.Tumor cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic conditions.Investigation on energy metabolism pathway in cancer cells has aroused the interest of cancer researchers all around the world.In recent years,plentiful studics suggest that targeting the peculiar cancer energy metabolic pathways,including glycolysis,mitochondrial respiration,amino acid metabolism,and fatty acid oxidation may be an effective strategy to starve cancer cells by blocking essential nutrients.Natural products (NPs)are considered as the “treasure trove of small molecules drugs” and have played an extremely remarkable role in the discovery and development of anticancer drugs.And numerous NPs have been reported to act on cancer energy metabolism targets.Herein,a comprehensive overview about cancer energy metabolism targets and their natural-occurring inhibitors is prepared.
基金financially supported by the National Natural Science Foundation of China (Grant No.21671055)Henan University First-class Discipline Cultivation Project (Grant No.2020YLZDYJ06)+1 种基金Medical Interdisciplinary Training Program of Henan University of China (Grant No.CJ1205A0240007)the Scientific and Technological Project of Henan province (Grant No. 212102310852)
文摘In this paper,a new organic–inorganic hybrid compound[Co(L)_(2)]2[W_(6)O_(19)](1)(HL=2-acetylpyridine thiosemicarbazone)was prepared and characterized.The compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration(MIC)against Staphylococcus aureus(S.aureus,0.06μg·mL^(−1))and Escherichia coli(E.coli,0.24μg·mL^(−1)),respectively.Furthermore,the potential mechanism of compound 1 was studied in detail.The potential causes of bacteria death were cell wall/membrane disruption,inhibition of intracellular respiratory chain dehydrogenases(RCD)activity,destruction of reactive oxygen species(ROS)and depletion of glutathione(GSH).
基金financially supported by National Mega-project for Innovative Drugs(grant number 2019ZX09721001-004-007)National Natural Science Foundation of China(NSFC)(NOs.81773594,U1803122,U1703111,81473254,and 81773637)+1 种基金the Fundamental Research Fund for the Central Universities(HUST COVID-19 Rapid Response Call,No.2020kfyXGYJ037,China)Liaoning Revitalization Talents Program(NO.XLYC1807182)
文摘The new coronavirus pneumonia(coronavirus disease 2019[COVID-19]),caused by the new coronavirus(severe acute respiratory syndrome coronavirus 2[SARS-CoV-2]),mainly manifests by fever,dry cough,and fatigue.The emergence of SARS-CoV-2 poses a huge threat to people’s lives.Unfortunately,so far,there are no effective treatment drugs and vaccines.Traditional Chinese medicine(TCM)has played an important role and achieved good results for treating this epidemic.More than 85%of patients with SARS-CoV-2 infection in China have received TCM treatment.In this article,we describe the progress of TCM for the COVID-19 therapy.
