To efficiently remove all recurrent lymph nodes(rLNs)and minimize complications,we developed a combination approach that consisted of ^(68)Gallium prostate-specific membrane antigen(PSMA)ligand positron emission tomog...To efficiently remove all recurrent lymph nodes(rLNs)and minimize complications,we developed a combination approach that consisted of ^(68)Gallium prostate-specific membrane antigen(PSMA)ligand positron emission tomography(PET)/computed tomography(CT)and integrated indocyanine green(ICG)-guided salvage lymph node dissection(sLND)for rLNs after radical prostatectomy(RP).Nineteen patients were enrolled to receive such treatment.^(68)Ga-PSMA ligand PET/CT was used to identify rLNs,and 5 mg of ICG was injected into the space between the rectum and bladder before surgery.Fluorescent laparoscopy was used to perform sLND.While extensive LN dissection was performed at level I,another 5 mg of ICG was injected via the intravenous route to intensify the fluorescent signal,and laparoscopy was introduced to intensively target stained LNs along levels I and II,specifically around suspicious LNs,with ^(68)Ga-PSMA ligand PET/CT.Next,both lateral peritonea were exposed longitudinally to facilitate the removal of fluorescently stained LNs at levels III and IV.In total,pathological analysis confirmed that 42 nodes were rLNs.Among 145 positive LNs stained with ICG,24 suspicious LNs identified with ^(68)Ga-PSMA ligand PET/CT were included.The sensitivity and specificity of ^(68)Ga-PSMA ligand PET/CT for detecting rLNs were 42.9%and 96.6%,respectively.For ICG,the sensitivity was 92.8%and the specificity was 39.1%.At a median follow-up of 15(interquartile range[IQR]:6–31)months,15 patients experienced complete biochemical remission(BR,prostate-specific antigen[PSA]<0.2 ng ml−1),and 4 patients had a decline in the PSA level,but it remained>0.2 ng ml−1.Therefore,^(68)Ga-PSMA ligand PET/CT integrating ICG-guided sLND provides efficient sLND with few complications for patients with rLNs after RP.展开更多
The study of tourism destination images is of great significance in the tourism discipline.Tourism user-generated content(UGC),i.e.,the feedback on tourism websites,provides rich information for constructing a destina...The study of tourism destination images is of great significance in the tourism discipline.Tourism user-generated content(UGC),i.e.,the feedback on tourism websites,provides rich information for constructing a destination image.However,it is difficult for tourism researchers to obtain a relatively complete and intuitive destination image due to the unintuitive destination image display,the significant variance in departure time and data length,and the destination type in UGC.We propose TDIVis,a carefully designed visual analytics system,aimed at obtaining a relatively comprehensive destination image.Specifically,a keyword-based sentiment visualization method is proposed to associate the cognitive image with the emotional image,and by this method,both time evolution analysis and classification analysis are considered;a multi-attribute association double sequence visualization method is proposed to associate two different types of text sequences and provide a dynamic visual encoding interaction method for the multi-attribute characteristics of sequences.The effectiveness and usability of TDIVis are demonstrated through four cases and a user study.展开更多
Dear Editor,Time-lapse systems(TLSs)have increasingly been introduced to fertility laboratories to improve the identification of embryo quality.TLSs detect some forms of abnormal division,such as direct and reverse cl...Dear Editor,Time-lapse systems(TLSs)have increasingly been introduced to fertility laboratories to improve the identification of embryo quality.TLSs detect some forms of abnormal division,such as direct and reverse cleavage divisions.Direct cleavage occurs when one blastomere divides directly into three or more daughter blastomeres.It strongly correlates with impaired preimplantation development,ploidy,and implantation capacity.展开更多
基金This work was supported by the National Natural Science Foundation of China(General Program,No.81772722)Guangdong Province Science and Technology Planning Project(No.2017B020227008).
文摘To efficiently remove all recurrent lymph nodes(rLNs)and minimize complications,we developed a combination approach that consisted of ^(68)Gallium prostate-specific membrane antigen(PSMA)ligand positron emission tomography(PET)/computed tomography(CT)and integrated indocyanine green(ICG)-guided salvage lymph node dissection(sLND)for rLNs after radical prostatectomy(RP).Nineteen patients were enrolled to receive such treatment.^(68)Ga-PSMA ligand PET/CT was used to identify rLNs,and 5 mg of ICG was injected into the space between the rectum and bladder before surgery.Fluorescent laparoscopy was used to perform sLND.While extensive LN dissection was performed at level I,another 5 mg of ICG was injected via the intravenous route to intensify the fluorescent signal,and laparoscopy was introduced to intensively target stained LNs along levels I and II,specifically around suspicious LNs,with ^(68)Ga-PSMA ligand PET/CT.Next,both lateral peritonea were exposed longitudinally to facilitate the removal of fluorescently stained LNs at levels III and IV.In total,pathological analysis confirmed that 42 nodes were rLNs.Among 145 positive LNs stained with ICG,24 suspicious LNs identified with ^(68)Ga-PSMA ligand PET/CT were included.The sensitivity and specificity of ^(68)Ga-PSMA ligand PET/CT for detecting rLNs were 42.9%and 96.6%,respectively.For ICG,the sensitivity was 92.8%and the specificity was 39.1%.At a median follow-up of 15(interquartile range[IQR]:6–31)months,15 patients experienced complete biochemical remission(BR,prostate-specific antigen[PSA]<0.2 ng ml−1),and 4 patients had a decline in the PSA level,but it remained>0.2 ng ml−1.Therefore,^(68)Ga-PSMA ligand PET/CT integrating ICG-guided sLND provides efficient sLND with few complications for patients with rLNs after RP.
基金Project supported by the Science&Technology Department of Sichuan Province,China(No.2018GZ0171)the Chengdu Science and Technology Bureau,China(No.2015-HM01-00484-SF)。
文摘The study of tourism destination images is of great significance in the tourism discipline.Tourism user-generated content(UGC),i.e.,the feedback on tourism websites,provides rich information for constructing a destination image.However,it is difficult for tourism researchers to obtain a relatively complete and intuitive destination image due to the unintuitive destination image display,the significant variance in departure time and data length,and the destination type in UGC.We propose TDIVis,a carefully designed visual analytics system,aimed at obtaining a relatively comprehensive destination image.Specifically,a keyword-based sentiment visualization method is proposed to associate the cognitive image with the emotional image,and by this method,both time evolution analysis and classification analysis are considered;a multi-attribute association double sequence visualization method is proposed to associate two different types of text sequences and provide a dynamic visual encoding interaction method for the multi-attribute characteristics of sequences.The effectiveness and usability of TDIVis are demonstrated through four cases and a user study.
基金This project was supported by Young Physicians Program of Chinese Medical Association(No.17020470716).
文摘Dear Editor,Time-lapse systems(TLSs)have increasingly been introduced to fertility laboratories to improve the identification of embryo quality.TLSs detect some forms of abnormal division,such as direct and reverse cleavage divisions.Direct cleavage occurs when one blastomere divides directly into three or more daughter blastomeres.It strongly correlates with impaired preimplantation development,ploidy,and implantation capacity.
