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基于FAERS数据库芬戈莫德在多发性硬化患者中的肿瘤风险信号挖掘 被引量:3
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作者 张千 颜明明 +2 位作者 赵晖 邱晓燕 钟明康 《药物流行病学杂志》 CAS 2023年第9期961-968,共8页
目的评估芬戈莫德在多发性硬化患者中潜在的肿瘤风险。方法提取美国食品药品管理局不良事件报告系统(FAERS)数据库2004年第一季度至2022年第四季度数据,采用报告比值比(ROR)法和信息成分(IC)法挖掘芬戈莫德在多发性硬化患者中潜在的肿... 目的评估芬戈莫德在多发性硬化患者中潜在的肿瘤风险。方法提取美国食品药品管理局不良事件报告系统(FAERS)数据库2004年第一季度至2022年第四季度数据,采用报告比值比(ROR)法和信息成分(IC)法挖掘芬戈莫德在多发性硬化患者中潜在的肿瘤不良事件信号。结果获得1628例与芬戈莫德治疗多发性硬化患者有关的肿瘤不良事件报告,报告例次数排名前3位的肿瘤类别依次为皮肤和黏膜恶性肿瘤(527例次)、乳腺癌(89例次)和女性生殖器官癌(43例次)。信号分析显示,报告例次数排名前6位的肿瘤依次是基底细胞癌(189例次,ROR=5.67,ROR_(025)=4.91,IC_(025)=2.23)、恶性黑色素瘤(105例次,ROR=3.29,ROR_(025)=2.71,IC_(025)=1.39)、鳞状细胞癌(62例次,ROR=2.91,ROR_(025)=2.27,IC_(025)=1.12)、乳腺浸润性导管癌(53例次,ROR=8.62,ROR_(025)=6.56,IC_(025)=2.46)、皮肤鳞状细胞癌(45例次,ROR=3.58,ROR_(025)=2.67,IC_(025)=1.31)和子宫癌(37例次,ROR=4.09,ROR_(025)=2.96,IC_(025)=1.41)。结论芬戈莫德在多发性硬化患者中有广泛的潜在肿瘤不良事件风险,理解这一现象需要进一步的临床研究来探索,并建议服用芬戈莫德的患者进行皮肤科随访。 展开更多
关键词 芬戈莫德 肿瘤 药品不良事件 多发性硬化 FAERS数据库 数据挖掘 药物警戒
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Body Weight Misperception and Weight Disorders among Chinese Children and Adolescents:A Latent Class Analysis 被引量:3
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作者 Ting-ting QIN Huang-guo XIONG +3 位作者 ming-ming yan Tong SUN Ling QIAN Ping YIN 《Current Medical Science》 SCIE CAS 2019年第5期852-862,共11页
Body misperception plays an important role in the development of weight and dietary disorders among children and adolescents.A school-based health promotion program(2014-2015)was conducted to promote the school health... Body misperception plays an important role in the development of weight and dietary disorders among children and adolescents.A school-based health promotion program(2014-2015)was conducted to promote the school health education and improve the teenagers'physical health among Chinese children and adolescents.Based on this program,we intended to examine weight status and weight misperception among Chinese children and adolescents and to explore the relationship between weight misperception and lifestyle behaviors.A total of 10708 Chinese children and adolescents in 3rd and 7th grade from Shandong and Qinghai province participated in the program.The participants,dietary and activity patterns were clustered by latent class analysis(LCA).Logistic regression analysis was undertaken to explore the relationship between weight perception and demographic factors or dietary and activity patterns.Given the gender-specific difference of children and adolescents,analyses were separately conducted among boys and girls.The total prevalence of weight misperception was 44.50%.Boys,especially those in higher grade and living in wealthier district,were more likely to misperceive body weight.Girls were more likely to overestimate their weight(26.10%)while boys tended to underestimate the weight(28.32%).Three latent dietary and activity patterns including obesogenic pattern,malnourished pattern and healthy pattern were derived.The participants who had weight misperception were more likely to choose unhealthy dietary and exercise activities.The high prevalence of weight misperception was closely related to the unhealthy weight pattern and unhealthy dietary or exercise patterns.Our research found that most children and adolescents failed to perceive their weight correctly and boys tended to underestimate their weight while girls were subjected to overestimation.So,comprehensive intervention programs should focus on improving self-weight awareness,and appropriate guidance should be made to lead the adolescents to more healthy weight pattern. 展开更多
关键词 WEIGHT perception children and adolescents obesity LIFESTYLE behavior pattern LATENT class ANALYSIS
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Multiple rare causes of post-traumatic elbow stiffness in an adolescent patient: A case report and review of literature 被引量:1
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作者 Bai-Qi Pan Jun Huang +2 位作者 Jiang-Dong Ni ming-ming yan Qin Xia 《World Journal of Clinical Cases》 SCIE 2019年第10期1191-1199,共9页
BACKGROUND Joint stiffness after elbow surgery is not a rare complication,and is always accompanied by deformity.The causes of joint stiffness are multiple in different patients,and divided into intrinsic and extrinsi... BACKGROUND Joint stiffness after elbow surgery is not a rare complication,and is always accompanied by deformity.The causes of joint stiffness are multiple in different patients,and divided into intrinsic and extrinsic causes.Herein,we report an unusual case of posttraumatic elbow stiffness due to multiple and rare causes.CASE SUMMARY A 19-year-old male was hospitalized with the loss of motion of the left elbow for over ten years.Left limb computed tomography revealed left elbow stiffness with bony block and connection.The patient underwent surgery,and the etiology of joint stiffness was found to be a rare combination of common and uncommon causes.During an 18-mo follow-up period,the patient’s left elbow had normal motion and he was symptom-free.CONCLUSION However,this case combined with multiple and rare causes highlights that the patient with scar physique is likely to be accompanied with more severe soft tissue,nerve contracture,and heterotypic ossification,even during recurrence. 展开更多
关键词 POST-TRAUMATIC Elbow stiffness Open surgery CONTRACTURE ULNAR NEURITIS Radial nerve SCAR Case report
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