Gastric cancer(GC)is the fifth most common cancer and the third leading cause of cancer-related death worldwide[1],Metastasis is the leading cause of GC mortality.The complex dynamic interactions between tumor cells a...Gastric cancer(GC)is the fifth most common cancer and the third leading cause of cancer-related death worldwide[1],Metastasis is the leading cause of GC mortality.The complex dynamic interactions between tumor cells and stromal cells in the tumor microenvironment are crucial for tumor metastasis.Many secreted cytokines have been well documented to mediate the crosstalk between tumor cells and stromal cells in a paracrine manner[2].However,how the juxtacrine signals transduced by adjacent cellcell adhesion modulate cancer metastasis has yet to be elucidated[3].As one of the most important cell-cell adhesion molecules,the classical cadherin superfamily also initiates different intracellular signaling cascades and regulates cytoskeletal dynamics,permeability,cell polarity,and tumor progression[4,5].展开更多
基金supported by the National Natural Science Foundation of China(81972276,31771540,82173040,91740205,and 31620103911)Natural Science Foundation of Zhejiang Province(LYY19H310011)Fundamental Research Funds for the Central Universities(2021QNA7004)。
文摘Gastric cancer(GC)is the fifth most common cancer and the third leading cause of cancer-related death worldwide[1],Metastasis is the leading cause of GC mortality.The complex dynamic interactions between tumor cells and stromal cells in the tumor microenvironment are crucial for tumor metastasis.Many secreted cytokines have been well documented to mediate the crosstalk between tumor cells and stromal cells in a paracrine manner[2].However,how the juxtacrine signals transduced by adjacent cellcell adhesion modulate cancer metastasis has yet to be elucidated[3].As one of the most important cell-cell adhesion molecules,the classical cadherin superfamily also initiates different intracellular signaling cascades and regulates cytoskeletal dynamics,permeability,cell polarity,and tumor progression[4,5].
