Independent Vector Analysis Based Blind Interference Reduction and Signal Recovery for MIMO IoT Green Communications

In application to time convolutive mixing model or frequency domain blind separation model for wireless receiving applications,frequency domain independent component analysis(FDICA)has been a very popular method but with adverse random permutation ambiguity influence.In order to solve this inherent problem in FDICA assisted multiple-input multiple-output orthogonal frequency-division multiplexing(MIMO-OFDM)based the Internet of Thing(IoT)systems,this paper proposes an new detection mechanism,named independent vector analysis(IVA),for realizing blind adaptive signal recovery in MIMO IoT green communication to reduce inter-carrier interference(ICI)and multiple access interference(MAI).IVA jointly implements separation work for different frequency bin data while the FDICA deals with it separately.In IVA,the dependencies of frequency bins can be exploited in mitigating the random permutation problem.In addition,multivariate prior distributions are employed to preserve the inter-frequency dependencies for individual sources,which can result in separation performance enhancement.Simulation results and analysis corroborate the effectiveness of the proposed method.

Antifungal effects of BiOBr nanosheets carrying surfactant cetyltrimethylammonium bromide

BiOBr nanosheets are important photocatalytic nanomaterials. However, their biological effects remain to be explored. In this study, we investigated the antifungal effect of BiOBr nanosheets on Candida albicans. Strikingly,the nanosheets strongly inhibited the growth of C. albicans [IC50=（96±4.7） mg/L],hyphal development and biofilm formation. Compareed to the antifungal effect of the cationic surfactant cetyltrimethylammonium bromide, the inhibitory effect of the nanosheets on fungal pathogen was attributed to cetyltrimethylammonium bromide adsorbed by the nanosheets. Thermal gravity analysis and cetyltrimethylammonium bromide release experiment indicated that only 0.42% cetyltrimethylammonium bromide on BiOBr nanosheets was released. Taken together, this study uncovers the contribution of surfactant released from the nanosheets to their antifungal activity.

Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions

In this study,we prepared mitochondrion targeting peptide-grafted magnetic graphene oxide(GO)nanocarriers for efficient impairment of the tumor mitochondria.The two-dimensional GOMNP-MitP nanosheets were synthesized by grafting magnetic y-Fe_(2)O_(3)to the surface of GO,followed by covalent modification of mitochondrion targeting peptide(MitP).GOMNP-MitP exhibited the high capacity of loading the anticancer drug mitoxantrone(MTX),and preferentially targeted the tumor mitochondria.With the aid of alternating magnetic field(AMF),the MTX-loading GOMNP-MitP released MTX to the mitochondria,severely impairing mitochondrial functions,including attenuation of ATP production,decrease in mitochondrial membrane potential(MMP),and further leading to activation of apoptosis.This study realized high-efficient mitochondrion-ta rgeting drug delivery for anticancer therapy by twodimensional nanoplatforms.

Pathogen infection-responsive nanoplatform targeting macrophage endoplasmic reticulum for treating life-threatening systemic infection

Systemic infections caused by life-threatening pathogens represent one of the main factors leading to clinical death.In this study,we developed a pathogen infection-responsive and macrophage endoplasmic reticulum-targeting nanoplatform to alleviate systemic infections.The nanoplatform is composed of large-pore mesoporous silica nanoparticles(MSNs)grafted by an endoplasmic reticulum-targeting peptide,and a pathogen infection-responsive cap containing the reactive oxygen speciescleavable boronobenzyl acid linker and bovine serum albumin.The capped MSNs exhibited the capacity to high-efficiently load the antimicrobial peptide melittin,and to rapidly release the cargo triggered by H_(2)O_(2) or the pathogen-macrophage interaction system,but had no obvious toxicity to macrophages.During the interaction with pathogenic Candida albicans cells and macrophages,the melittin-loading nanoplatform MSNE+MEL+TPB strongly inhibited pathogen growth,survived macrophages,and suppressed endoplasmic reticulum stress together with pro-inflammatory cytokine secretion.In a systemic infection model,the nanoplatform efficiently prevented kidney dysfunction,alleviated inflammatory symptoms,and protected the mice from death.This study developed a macrophage organelle-targeting nanoplatform for treatment of life-threatening systemic infections.

磷脂/蛋白介导的氧化亚铜纳米粒子组装体对致病真菌生长及生物被膜的抑制作用

随着艾滋病感染、化疗、放疗等免疫缺陷人群的日益增加,病原真菌感染已成为人类健康的巨大威胁.本文构建了一种新型的病原真菌响应性氧化亚铜纳米粒子组装体,用于特异性靶向并抑制病原真菌的生长与生物被膜形成.首先通过在氧化亚铜纳米粒子表面包覆磷脂酰乙醇胺及牛血清白蛋白,继而包覆分子通过疏水及静电作用驱动纳米粒子形成微米组装体.形成的组装体能够在病原真菌(白念珠菌)的诱导下进行解组装,导致纳米粒子与病原真菌的细胞壁紧密结合.共聚焦显微观察及细胞活性检测表明,组装体能够显著抑制病原真菌的生长及生物被膜形成,且对哺乳动物细胞表现出极低的毒性.体内小鼠伤口感染模型进一步显示组装体能够促进病原真菌感染伤口的愈合,并降低伤口组织的真菌负载量.该研究为病原菌响应性纳米组装体的开发及其在抗真菌感染治疗中的高效与安全应用提供了新的思路.