Better torque performance and higher reliability have long been the focus of research for slotted limited-angle torque motors(LATMs),which are primarily used to position first-stage valves in electrohydraulic servosys...Better torque performance and higher reliability have long been the focus of research for slotted limited-angle torque motors(LATMs),which are primarily used to position first-stage valves in electrohydraulic servosystems.This paper presents a high reliability axial-flux slotted LATM with quasi-Halbach array for torque performance improvement including constant torque range(CTR)and output torque.Firstly,the structure with two sets of windings and the operation principle of the proposed slotted LATM is analyzed.Secondly,a brief design procedure is presented,the structure selections of open slot and double-stator single-rotor(DSSR)interior rotor with surface mounted quasi-Halbach permanent magnet(PM)array are illustrated,and the geometric parameters are optimized to obtain the optimal design of the proposed slotted LATM.Then,3-D finite-element method(FEM)is employed to compare the proposed slotted LATM with the conventional surface mounted PM slotted LATM in terms of cogging torque,no-load back EMF,and output torque,and the results show that the proposed LATM with quasi-Halbach array has a 10%improvement in output torque and a 25%improvement in CTR.Meanwhile,the flux linkages and torque performance of the two sets of windings under various conditions verify good magnetic isolation.Finally,prototypes of two different rotor types are manufactured and a series of experiments are performed to validate the analysis.展开更多
The rapid improvement in the running speed,transmission efficiency,and power density of miniaturized devices means that multifunctional flexible composites with excellent thermal management capability and high electro...The rapid improvement in the running speed,transmission efficiency,and power density of miniaturized devices means that multifunctional flexible composites with excellent thermal management capability and high electromagnetic interference(EMI)shielding performance are urgently required.Here,inspired by the fibrous pathways of the human nervous system,a“core–sheath”fibers structured strategy was proposed to prepare thermoplastic polyurethane/polydopamine/carbon nanotube(TPU/PDA/CNT)composites film with thermal management capability and EMI shielding performance.Firstly,TPU@PDA@CNT fibers with CNT shell were prepared by a facile polydopamine-assisted coating on electrospun TPU fibers.Subsequently,TPU/PDA/CNT composites with three-dimensional(3D)fibrous CNT“tracks”are obtained by a hot-pressing process,where CNTs distributed on adjacent fibers are compactly contacted.The fabricated TPU/PDA/CNT composites exhibit a high in-plane thermal conductivity(TC)of 9.6 W/(m·K)at low CNT loading of 7.6 wt.%.In addition,it also presents excellent mechanical properties and excellent EMI shielding effectiveness of 48.3 dB as well as multi-source driven thermal management capabilities.Hence,this study provides a simple yet scalable technique to prepare composites with advanced thermal management and EMI shielding performance to develop new-generation wireless communication technologies and portable intelligent electronic devices.展开更多
The toxicokinetic(TK)model‐derived kinetic bioconcentration factor(BCFk)provides a quantitatively comparable index to estimate the bioaccumulation potential of nanoparticles(NPs)that barely reach thermodynamic equili...The toxicokinetic(TK)model‐derived kinetic bioconcentration factor(BCFk)provides a quantitatively comparable index to estimate the bioaccumulation potential of nanoparticles(NPs)that barely reach thermodynamic equilibrium in aquatic organisms,but experimental data are limited for various NPs.In the present study,a machine learning model was applied to offer reliable in silico predictions for the dynamic body burden of diverse NPs to derive corresponding parameters for the TK model.The developed eXtreme Gradient Boosting‐derived TK(XGB‐TK)model was applied to predict BCFk results for a broad range of metallic or carbonaceous NPs,with an appreciable prediction R2 of 0.96.The BCFk values were predicted based on a random combination of selected variable features,revealing that their bioaccumulation potential showed an overall negative correlation with NP density or organism size.By applying importance analysis and partial dependence plots,NP density and organism size were revealed to be the top essential features that impact the bioaccumulation potential.The conjunctively used XGB‐TK model enabled a prior comparison for diverse NPs and straightforward derivation on the dependency of features,which could also guide the bioaccumulation mechanism exploration and experimental condition formulation.展开更多
Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we f...Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications.展开更多
The effects of Cu on stacking fault energy,dislocation slip,mechanical twinning,and strain hardening in Fe–20Mn–1.3C twinning-induced plasticity(TWIP) steels were systematically investigated.The stacking fault ene...The effects of Cu on stacking fault energy,dislocation slip,mechanical twinning,and strain hardening in Fe–20Mn–1.3C twinning-induced plasticity(TWIP) steels were systematically investigated.The stacking fault energy was raised with an average slope of 2 mJ/m2 per 1 wt% Cu.The Fe–20Mn–1.3C–3Cu steel exhibited superior tensile properties,with the ultimate tensile strength reached at 2.27 GPa and elongation up to 96.9% owing to the high strain hardening that occurred.To examine the mechanism of this high strain hardening,dislocation density determination by XRD was calculated.The dislocation density increased with the increasing strain,and the addition of Cu resulted in a decrease in the dislocation density.A comparison of the strain-hardening behavior of Fe–20Mn–1.3C and Fe–20Mn–1.3C–3Cu TWIP steels was made in terms of modified Crussard–Jaoul(C–J) analysis and microstructural observations.Especially at low strains,the contributions of all the relevant deformation mechanisms—slip,twinning,and dynamic strain aging—were quantitatively evaluated.The analysis revealed that the dislocation storage was the leading factor to the increase of the strain hardening,while dynamic strain aging was a minor contributor to strain hardening.Twinning,which interacted with the matrix,acted as an effective barrier to dislocation motion.展开更多
COVID-19 caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection likely ranks among the deadliest diseases in human history.As with other coronaviruses,SARS-CoV-2 infection damages not only the ...COVID-19 caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection likely ranks among the deadliest diseases in human history.As with other coronaviruses,SARS-CoV-2 infection damages not only the lungs but also the heart and many other organs that express angiotensin-converting enzyme 2(ACE2),a receptor for SARS-CoV-2.COVID-19 has upended lives worldwide.Dietary behaviors have been altered such that they favor metabolic and cardiovascular complications,while patients have avoided hospital visits because of limited resources and the fear of infection,thereby increasing out-hospital mortality due to delayed diagnosis and treatment.Clinical observations show that sex,age,and race all influence the risk for SARS-CoV-2 infection,as do hypertension,obesity,and pre-existing cardiovascular conditions.Many hospitalized COVID-19 patients suffer cardiac injury,acute coronary syndromes,or cardiac arrhythmia.SARS-CoV-2 infection may lead to cardiomyocyte apoptosis and necrosis,endothelial cell damage and dysfunction,oxidative stress and reactive oxygen species production,vasoconstriction,fibrotic and thrombotic protein expression,vascular permeability and microvascular dysfunction,heart inflammatory cell accumulation and activation,and a cytokine storm.Current data indicate that COVID-19 patients with cardiovascular diseases should not discontinue many existing cardiovascular therapies such as ACE inhibitors,angiotensin receptor blockers,steroids,aspirin,statins,and PCSK9 inhibitors.This review aims to furnish a framework relating to COVID-19 and cardiovascular pathophysiology.展开更多
基金supported in part by the National Nature Science Foundation of China(NSFC)under Project 52122705。
文摘Better torque performance and higher reliability have long been the focus of research for slotted limited-angle torque motors(LATMs),which are primarily used to position first-stage valves in electrohydraulic servosystems.This paper presents a high reliability axial-flux slotted LATM with quasi-Halbach array for torque performance improvement including constant torque range(CTR)and output torque.Firstly,the structure with two sets of windings and the operation principle of the proposed slotted LATM is analyzed.Secondly,a brief design procedure is presented,the structure selections of open slot and double-stator single-rotor(DSSR)interior rotor with surface mounted quasi-Halbach permanent magnet(PM)array are illustrated,and the geometric parameters are optimized to obtain the optimal design of the proposed slotted LATM.Then,3-D finite-element method(FEM)is employed to compare the proposed slotted LATM with the conventional surface mounted PM slotted LATM in terms of cogging torque,no-load back EMF,and output torque,and the results show that the proposed LATM with quasi-Halbach array has a 10%improvement in output torque and a 25%improvement in CTR.Meanwhile,the flux linkages and torque performance of the two sets of windings under various conditions verify good magnetic isolation.Finally,prototypes of two different rotor types are manufactured and a series of experiments are performed to validate the analysis.
基金supported by the National Natural Science Foundation of China(Nos.21704096,51703217,and 12072325)the Natural Science Foundation of Henan Province(No.20A430028).
文摘The rapid improvement in the running speed,transmission efficiency,and power density of miniaturized devices means that multifunctional flexible composites with excellent thermal management capability and high electromagnetic interference(EMI)shielding performance are urgently required.Here,inspired by the fibrous pathways of the human nervous system,a“core–sheath”fibers structured strategy was proposed to prepare thermoplastic polyurethane/polydopamine/carbon nanotube(TPU/PDA/CNT)composites film with thermal management capability and EMI shielding performance.Firstly,TPU@PDA@CNT fibers with CNT shell were prepared by a facile polydopamine-assisted coating on electrospun TPU fibers.Subsequently,TPU/PDA/CNT composites with three-dimensional(3D)fibrous CNT“tracks”are obtained by a hot-pressing process,where CNTs distributed on adjacent fibers are compactly contacted.The fabricated TPU/PDA/CNT composites exhibit a high in-plane thermal conductivity(TC)of 9.6 W/(m·K)at low CNT loading of 7.6 wt.%.In addition,it also presents excellent mechanical properties and excellent EMI shielding effectiveness of 48.3 dB as well as multi-source driven thermal management capabilities.Hence,this study provides a simple yet scalable technique to prepare composites with advanced thermal management and EMI shielding performance to develop new-generation wireless communication technologies and portable intelligent electronic devices.
基金National Natural Science Foundation of China,Grant/Award Numbers:22125602,22206087,U2067215National Key R&D Program of China,Grant/Award Number:2020YFC1806703Fundamental Research Funds for the Central Universities,Grant/Award Number:XJ20222005501。
文摘The toxicokinetic(TK)model‐derived kinetic bioconcentration factor(BCFk)provides a quantitatively comparable index to estimate the bioaccumulation potential of nanoparticles(NPs)that barely reach thermodynamic equilibrium in aquatic organisms,but experimental data are limited for various NPs.In the present study,a machine learning model was applied to offer reliable in silico predictions for the dynamic body burden of diverse NPs to derive corresponding parameters for the TK model.The developed eXtreme Gradient Boosting‐derived TK(XGB‐TK)model was applied to predict BCFk results for a broad range of metallic or carbonaceous NPs,with an appreciable prediction R2 of 0.96.The BCFk values were predicted based on a random combination of selected variable features,revealing that their bioaccumulation potential showed an overall negative correlation with NP density or organism size.By applying importance analysis and partial dependence plots,NP density and organism size were revealed to be the top essential features that impact the bioaccumulation potential.The conjunctively used XGB‐TK model enabled a prior comparison for diverse NPs and straightforward derivation on the dependency of features,which could also guide the bioaccumulation mechanism exploration and experimental condition formulation.
基金This work was supported by the National Key R&D Program of China[2019YFA0110600]the National Natural Science Foundation of China[81972070,81201212]+1 种基金the China Postdoctoral Science Foundation Grant[2019TQ0379,2019M663262]PLA Youth Project for Medical Science(18QNP057).
文摘Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications.
基金financially supported by the Major Project for Industry-University-Research of Fujian Province,China (No.2011H6012)the Natural Science Foundation of Fujian Province,China (No.2011J01292)the Key Project of Fujian Provincial Department of Science and Technology (No.2011H0001)
文摘The effects of Cu on stacking fault energy,dislocation slip,mechanical twinning,and strain hardening in Fe–20Mn–1.3C twinning-induced plasticity(TWIP) steels were systematically investigated.The stacking fault energy was raised with an average slope of 2 mJ/m2 per 1 wt% Cu.The Fe–20Mn–1.3C–3Cu steel exhibited superior tensile properties,with the ultimate tensile strength reached at 2.27 GPa and elongation up to 96.9% owing to the high strain hardening that occurred.To examine the mechanism of this high strain hardening,dislocation density determination by XRD was calculated.The dislocation density increased with the increasing strain,and the addition of Cu resulted in a decrease in the dislocation density.A comparison of the strain-hardening behavior of Fe–20Mn–1.3C and Fe–20Mn–1.3C–3Cu TWIP steels was made in terms of modified Crussard–Jaoul(C–J) analysis and microstructural observations.Especially at low strains,the contributions of all the relevant deformation mechanisms—slip,twinning,and dynamic strain aging—were quantitatively evaluated.The analysis revealed that the dislocation storage was the leading factor to the increase of the strain hardening,while dynamic strain aging was a minor contributor to strain hardening.Twinning,which interacted with the matrix,acted as an effective barrier to dislocation motion.
基金Dr.Shi receives funding support from the National Heart,Lung,and Blood Institute(R01HL151627)the National Institute of Neurological Disorders and Stroke(R01AG063839)+1 种基金Dr.Libby receives funding support from the National Heart,Lung,and Blood Institute(1R01HL134892)the American Heart Association(18CSA34080399),and the RRM Charitable Fund,and the Simard Fund.
文摘COVID-19 caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection likely ranks among the deadliest diseases in human history.As with other coronaviruses,SARS-CoV-2 infection damages not only the lungs but also the heart and many other organs that express angiotensin-converting enzyme 2(ACE2),a receptor for SARS-CoV-2.COVID-19 has upended lives worldwide.Dietary behaviors have been altered such that they favor metabolic and cardiovascular complications,while patients have avoided hospital visits because of limited resources and the fear of infection,thereby increasing out-hospital mortality due to delayed diagnosis and treatment.Clinical observations show that sex,age,and race all influence the risk for SARS-CoV-2 infection,as do hypertension,obesity,and pre-existing cardiovascular conditions.Many hospitalized COVID-19 patients suffer cardiac injury,acute coronary syndromes,or cardiac arrhythmia.SARS-CoV-2 infection may lead to cardiomyocyte apoptosis and necrosis,endothelial cell damage and dysfunction,oxidative stress and reactive oxygen species production,vasoconstriction,fibrotic and thrombotic protein expression,vascular permeability and microvascular dysfunction,heart inflammatory cell accumulation and activation,and a cytokine storm.Current data indicate that COVID-19 patients with cardiovascular diseases should not discontinue many existing cardiovascular therapies such as ACE inhibitors,angiotensin receptor blockers,steroids,aspirin,statins,and PCSK9 inhibitors.This review aims to furnish a framework relating to COVID-19 and cardiovascular pathophysiology.