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晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测 被引量:13
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作者 Qiao YANG mingjing chen +13 位作者 Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang chen Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第12期I0007-I0018,共12页
背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性... 背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 展开更多
关键词 血PD-L1 免疫检查点抑制剂 NSCLC 外泌体 生物标志物
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Constraints on Dark Energy from the CSST Galaxy Clusters
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作者 Yufei Zhang mingjing chen +1 位作者 Zhonglue Wen Wenjuan Fang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2023年第4期110-120,共11页
We study the potential of the galaxy cluster sample expected from the Chinese Space Station Telescope(CSST)survey to constrain dark energy properties.By modeling the distribution of observed cluster mass for a given t... We study the potential of the galaxy cluster sample expected from the Chinese Space Station Telescope(CSST)survey to constrain dark energy properties.By modeling the distribution of observed cluster mass for a given true mass to be log-normal and adopting a selection threshold in the observed mass M_(200m)≥0.836×10^(14)h^(-1)M_(⊙),we find about 4.1×10^(5)clusters in the redshift range 0≤z≤1.5 can be detected by the CSST.We construct the Fisher matrix for the cluster number counts from CSST,and forecast constraints on dark energy parameters for models with constant(w_(0)CDM)and time dependent(w_(0)w_(a)CDM)equation of state.In the self-calibration scheme,the dark energy equation of state parameter w_(0)of the w_(0)CDM model can be constrained toΔw_(0)=0.036.If w_(a)is added as a free parameter,we obtainΔw_(0)=0.077 andΔw_(a)=0.39 for the w_(0)w_(a)CDM model,with a Figure of Merit for(w_(0),w_(a))of 68.99.Should we have perfect knowledge of the observable-mass scaling relation("known SR"scheme),we would obtainΔw_(0)=0.012 for the w_(0)CDM model,andΔw_(0)=0.062 andΔw_(a)=0.24 for the w_(0)w_(a)CDM model.The dark energy Figure of Merit of(w_(0),w_(a))increases to 343.25.This indicates again the importance of calibrating the observable-mass scaling relation for optically selected galaxy clusters.By extending the_(max)imum redshift of the clusters from z_(max)~1.5 to Z_(max)~2,the dark energy Figure of Merit for(w_(0),w_(a))increases to 89.72(self-calibration scheme)and 610.97("known SR"scheme),improved by a factor of~1.30 and~1.78,respectively.We find that the impact of clusters’redshift uncertainty on the dark energy constraints is negligible as long as the redshift error of clusters is smaller than 0.01,achievable by CSST.We also find that the bias in logarithm mass must be calibrated to be 0.30 or better to avoid significant dark energy parameter bias. 展开更多
关键词 (cosmology:)dark energy-galaxies CLUSTERS general-(cosmology:)cosmological parameters
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构建准层状自空穴掺杂SnSe取向薄膜获得优异热电功率因子和输出功率密度 被引量:1
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作者 薛宇利 王晴 +7 位作者 高志 钱鑫 王江龙 闫国英 陈明敬 赵立东 王淑芳 李志亮 《Science Bulletin》 SCIE EI CAS CSCD 2023年第22期2769-2778,M0005,共11页
热电技术可以实现热能与电能的相互转换,其开发利用对于缓解能源危机具有重要意义.近10年来,SnSe因其潜在的高能量转换效率、绿色环保和低成本特性而备受关注.但SnSe的固有载流子浓度低(约10~(17)cm^(-3)),导致其功率因子偏低,从而限制... 热电技术可以实现热能与电能的相互转换,其开发利用对于缓解能源危机具有重要意义.近10年来,SnSe因其潜在的高能量转换效率、绿色环保和低成本特性而备受关注.但SnSe的固有载流子浓度低(约10~(17)cm^(-3)),导致其功率因子偏低,从而限制了SnSe基器件的输出功率密度.因此,探索新的载流子浓度优化策略对于SnSe的应用至关重要.此外,与三维块体相比,二维薄膜更易和现代半导体工艺相兼容,在热电微纳米器件的构筑和应用方面具有独特优势.本文报道了一种利用非原位硒化技术,通过电荷转移和自空穴掺杂效应来优化a轴取向SnSe基薄膜的载流子浓度.当硒化时间为20 min时,薄膜载流子浓度可提高至10~(18)cm^(-3)数量级,形成了准层状的自空穴掺杂SnSe基薄膜,其功率因子在600 K时达到了5.9μW cm^(-1)K^(-2).由硒化处理的SnSe基取向薄膜构筑的热电发电机在50和90 K的温差下分别具有约83、838μW cm^(-2)的超高功率密度.非原位硒化技术可以有效提高SnSe基薄膜的载流子浓度,为其他热电材料性能优化提供了一种新策略. 展开更多
关键词 Thermoelectric property Thin film Tin selenide Post-selenization Carrier concentration
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Enhancing thermoelectric performance of n-type AgBi_(3)S_(5)through synergistically optimizing the effective mass and carrier mobility 被引量:1
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作者 Xin Qian Xiaoxue Zhang +5 位作者 Haoran Guo Bangfu Ding mingjing chen Jiang-Long Wang Li-Dong Zhao Shu-Fang Wang 《Journal of Materiomics》 SCIE CSCD 2023年第5期874-881,共8页
AgBi_(3)S_(5) is a new n-type thermoelectric material that is environmentally friendly and composed of elements of earth-abundant,non-toxic and high performance-cost ratio.This compound features an intrinsically low t... AgBi_(3)S_(5) is a new n-type thermoelectric material that is environmentally friendly and composed of elements of earth-abundant,non-toxic and high performance-cost ratio.This compound features an intrinsically low thermal conductivity derived from its complex monoclinic structure.However,the terrible electrical transport properties greatly limited the improvement of thermoelectric performance.Most previous studies considered that carrier concentration is the main reason for low electrical conductivity and focused on improving carrier concentration by aliovalent ion doping.In this work,we found that the critical parameter that restricts the electric transport performance of AgBi_(3)S_(5)was the extremely low carrier mobility instead of the carrier concentration.According to the Pisarenko relationships and density functional theory calculations,Nb doping can sharpen the conduction band of AgBi_(3)S_(5),which contributes to reducing the effective mass and improving the carrier mobility.With a further increase of the Nb doping content,the conduction band convergence can enlarge the effective mass and preserve the carrier mobility.Combined with the decrease in lattice thermal conductivity due to the intensive phone scattering,a maximum ZT value of~0.50 at 773 K was achieved in Ag_(0.97)Nb_(0.03)Bi_(3)S_(5),which was~109.6%higher than that of pure AgBi3S5.This work will stimulate the new exploration of high-performance thermoelectric materials in ternary metal sulfides. 展开更多
关键词 THERMOELECTRIC AgBi_(3)S_(5) Effective mass Carrier mobility ZT value
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