宣肺败毒汤治疗新型冠状病毒感染肺炎的随机对照试验

[目的]评价宣肺败毒汤治疗普通型新型冠状病毒感染(COVID-19)的有效性和安全性。[方法]将符合条件的普通型COVID-19患者随机分为A组(宣肺败毒汤联合常规治疗)、B组(甘露消毒汤联合常规治疗)、C组(仅常规治疗)。疗程14天。主要结局指标为SARS-CoV-2核酸转阴时间和住院天数。次要结局指标是症状消失率。安全性指标为药物相关不良事件。[结果]共纳入103例普通型COVID-19患者,随机分为A组(34例)、B组(35例)和C组(34例)。SARS-CoV-2核酸转阴时间最短的是A组(9.88±3.62天),其次是C组(11.20±2.93天)和B组(12.69±4.11天)。三组间差异有统计学意义(P=0.010)。A组住院天数最短(14.00±6.55天),其次是B组(15.40±4.02天)和C组(16.38±5.73天)。组间差异有统计学意义(P=0.019)。各组症状消失率比较,差异无统计学意义(P>0.05)。三组均未发生药物相关不良事件。[结论]宣肺败毒汤治疗普通型COVID-19安全有效,可缩短SARS-CoV-2核酸转阴时间及住院时间。

IGBT Temperature Field Monitoring Based on Reduced-order Model

With the rapid development of the world economy,IGBT has been widely used in motor drive and electric energy conversion.In order to timely detect the fatigue damage of IGBT,it is necessary to monitor the junction temperature of IGBT.In order to realize the fast calculation of IGBT junction temperature,a finite element method of IGBT temperature field reduction is proposed in this paper.Firstly,the finite element calculation process of IGBT temperature field is introduced and the linear equations of finite element calculation of temperature field are derived.Temperature field data of different working conditions are obtained by finite element simulation to form the sample space.Then the covariance matrix of the sample space is constructed,whose proper orthogonal decomposition and modal extraction are carried out.Reasonable basis vector space is selected to complete the low dimensional expression of temperature vector inside and outside the sample space.Finally,the reduced-order model of temperature field finite element is obtained and solved.The results of the reduced order model are compared with those of the finite element method,and the performance of the reduced-order model is evaluated from two aspects of accuracy and rapidity.

浅析心血管医院规划与建设方案——以中国医学科学院阜外医院深圳医院三期项目为例

心血管疾病具有突发性、紧急性、严重性特点,是居民疾病死亡的首要原因之一。论文结合目前公立医院发展及建设背景,从“心系自然,守护健康”建筑设计理念、“协调、平衡、融合”功能布局思路以及多层叠加“十字立体”交通流线规划三个方面分析中国医学科学院阜外医院深圳医院项目规划建设工作要点,通过实例剖析以期为心血管医疗设施规划及建设提供有价值的参考。

浅谈“三合一”制度下公立医院建设前期管理

“十四五”期间,在财政资金有限的情况下,政府投资不断增大,新一轮医院的建设工作和管理思路发生了较大转变,从而也引起了医院项目建设前期管理的变化。论文紧扣深圳市委市政府关于医疗卫生项目基建、设备、信息化“三合一”“固投与开办费一体化”审批的工作要求,结合公立医院项目前期建设特点,分析了医院前期管理工作要点,并提出提升医院前期管理工作建议,以期为“三合一”审批制度下公立医院建设项目前期管理工作提供有价值的参考。

Outcome measures in clinical trials of traditional Chinese medicine for stable angina pectoris

Objective:This work aimed to present a descriptive analysis of the outcome measures used in clinical trials of traditional Chinese medicine(TCM)for patients with stable angina pectoris,and to provide baseline data for the development of core outcome sets(COSs)for relevant clinical trials.Methods:Medical databases were searched to identify randomized trials of the effects of TCM for the treatment of stable angina pectoris.Outcome measures of each trial were extracted.Descriptive statistics were used to analyze the baseline characteristics of outcomes in clinical trials of TCM.Results:94 randomized trials(with 9,111 participants)involving 79 different outcomes were identified.The mean number of outcomes was 5(1-21 per trial).The 5 most commonly reported outcomes were efficacy rate of electrocardiogram,efficacy rate of angina pectoris,efficacy rate of TCM syndrome,fasting lipid indices,and withdrawal rate of nitroglycerin.Several challenges were identified:(1)significant heterogeneity of outcomes and differences in the technique and timing of the measurement of the same outcome;(2)transformation of continuous data into categorical data and presented as such in>90% of trials;(3)few trials on the outcomes associated with the advantages and characteristics of TCM;and(4)selective reporting of outcomes.Conclusions:The outcomes used are excessively heterogenous,and the choice of some outcomes(timing and techniques)for measurement is confusing or inappropriate.Hence,developing and implementing a COS is necessary for greater consistency.

Synergistic tuning of electrochemical surface area and surface Co^(3+)by oxygen plasma enhances the capacities of Co_(3)O_(4)lithium-oxygen battery cathodes

Modifying electrochemical surface area(ECSA)and surface chemistry are promising approaches to enhance the capacities of oxygen cathodes for lithium-oxygen(Li-O_(2))batteries.Although various chemical approaches have been successfully used to tune the cathode surface,versatile physical techniques including plasma etching etc.could be more effortless and effective than arduous chemical treatments.Herein,for the first time,we propose a facile oxygen plasma treatment to simultaneously etch and modify the surface of Co_(3)O_(4)nanosheet arrays(NAs)cathode for Li-O_(2)batteries.The oxygen plasma not only etches Co_(3)O_(4)nanosheets to enhance the ECSA but also lowers the oxygen vacancy concentration to enable a Co^(3+)-rich surface.In addition,the NA architecture enables the full exposure of oxygen vacancies and surface Co^(3+)that function as the catalytically active sites.Thus,the synergistic effects of enhanced ECSA,modest oxygen vacancy and high surface Co^(3+)achieve a significantly enhanced reversible capacity of 3.45 mAh/cm^(2)for Co_(3)O_(4)NAs.This work not only develops a promising high-capacity cathode for Li-O_(2)batteries,but also provides a facile physical method to simultaneously tune the nanostructure and surface chemistry of energy storage materials.