To the Editor:High-frequency resistance(typically≥15-25%viral quasispecies)detected by conventional resistance assays has long been associated with failure of antiretroviral therapy(ART)to suppress viral replication,...To the Editor:High-frequency resistance(typically≥15-25%viral quasispecies)detected by conventional resistance assays has long been associated with failure of antiretroviral therapy(ART)to suppress viral replication,[1]but the impact of pre-existing lowfrequency resistance on virological response is controversial.Previous studies have shown an increased likelihood of virological response failure in patients with preexisting low-frequency resistance mutations after initiation of antiviral therapy,especially primary ART regimens containing non-nucleoside reverse transcriptase inhibitors(NNRTIs).[2]However,some studies have concluded differently,suggesting that pre-existing lowfrequency resistance mutations do not correlate with viral response failure.[3]This may be related to the method of detection of pre-existing low-frequency resistance mutations.展开更多
基金supported by the 2020 Annual Medical Research Project of Jiangsu Commission of Health(No.ZDA 2020014)the Key Project supported by Medical Science and Technology Development Foundation,Nanjing Department of Health(Nos.ZKX 22040 and ZKX 19048)
文摘To the Editor:High-frequency resistance(typically≥15-25%viral quasispecies)detected by conventional resistance assays has long been associated with failure of antiretroviral therapy(ART)to suppress viral replication,[1]but the impact of pre-existing lowfrequency resistance on virological response is controversial.Previous studies have shown an increased likelihood of virological response failure in patients with preexisting low-frequency resistance mutations after initiation of antiviral therapy,especially primary ART regimens containing non-nucleoside reverse transcriptase inhibitors(NNRTIs).[2]However,some studies have concluded differently,suggesting that pre-existing lowfrequency resistance mutations do not correlate with viral response failure.[3]This may be related to the method of detection of pre-existing low-frequency resistance mutations.
