In order to build a high-quality team of teachers in vocational higher education institutions, and investigate the current situation of teachers of common required courses in vocational higher education institutions o...In order to build a high-quality team of teachers in vocational higher education institutions, and investigate the current situation of teachers of common required courses in vocational higher education institutions of Hainan Province, an empirical research is conducted. A questionnaire survey was carried out in aspects of satisfaction of teaching and scientific research, professional quality, work saturation and teacher’s job satisfaction. The research results shows that the professional quality of teachers of common required courses cannot significantly influence the satisfaction of teaching and scientific research;Job saturation can positively influence teaching and research satisfaction;teaching and research satisfaction can positively influence teachers’ job satisfaction.展开更多
Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeu...Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeutic agents for various diseases.In the present study,we aimed to demonstrate that a herbal small RNA(s RNA),XKC-sRNA-h3(B55710460,F221.I000082.B11),exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme(ACE)in mice.When compared with captopril,oral administration of the sphingosine(d18:1)-XKC-s RNA-h3 bencaosome more effectively prevented angiotensin II-induced hypertensive cardiac damage and alleviated kidney injury in mice.Such findings indicated that XKC-sRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension.展开更多
Quasi-two-dimensi on al(2D)β-Ga2O3 is a rediscovered metal-oxide semiconductor with an ultra-wide bandgap of 4.6-4.9eV.It has been reported to be a promising material for next-generation power and radio frequency ele...Quasi-two-dimensi on al(2D)β-Ga2O3 is a rediscovered metal-oxide semiconductor with an ultra-wide bandgap of 4.6-4.9eV.It has been reported to be a promising material for next-generation power and radio frequency electronics.Field effect transistors(FETs)that can switch at high voltage are key compone nts in power and radio frequency devices,and reliable Ohmic con tacts are essential for high FET performance.However,obtaining low contact resistance onβ-Ga2O3 FETs is difficult since reactions betweenβ-Ga2O3 and metal contacts are not fully understood.Herein,we experimentally demonstrate the importanee of reactions at the metal/β-Ga2O3 interface and the corresponding effects of these reactions on FET performance.When Ti is employed as the metal contact,annealing ofβ-Ga2O3 FETs in argon can effectively transform Schottky contacts into Ohmic contacts and permit a large drain current density of-3.1 mA//μm.The contact resistance(Rcontact)between the Ti electrodes andβ-Ga2O3 decreased from^430 to^0.387Ω·mm after annealing.X-ray photoelectron spectroscopy(XPS)confirmed the formation of oxygen vacancies at the Ti/β-Ga2O3 interface after annealing,which is believed to cause the improved FET performance.The results of this study pave the way for greater application ofβ-Ga2O3 in electronics.展开更多
Developing convenient and accurate SARS-CoV-2 antigen test and serology test is crucial in curbing the global COVID-19 pandemic.In this work,we report an improved indium oxide(In2O3)nanoribbon field-effect transistor(...Developing convenient and accurate SARS-CoV-2 antigen test and serology test is crucial in curbing the global COVID-19 pandemic.In this work,we report an improved indium oxide(In2O3)nanoribbon field-effect transistor(FET)biosensor platform detecting both SARS-CoV-2 antigen and antibody.Our FET biosensors,which were fabricated using a scalable and cost-efficient lithography-free process utilizing shadow masks,consist of an In_(2)O_(3)channel and a newly developed stable enzyme reporter.During the biosensing process,the phosphatase enzymatic reaction generated pH change of the solution,which was then detected and converted to electrical signal by our In_(2)O_(3)FETs.The biosensors applied phosphatase as enzyme reporter,which has a much better stability than the widely used urease in FET based biosensors.As proof-of-principle studies,we demonstrate the detection of SARS-CoV-2 spike protein in both phosphate-buffered saline(PBS)buffer and universal transport medium(UTM)(limit of detection[LoD]:100 fg/mL).Following the SARS-CoV-2 antigen tests,we developed and characterized additional sensors aimed at SARS-CoV-2 IgG antibodies,which is important to trace past infection and vaccination.Our spike protein IgG antibody tests exhibit excellent detection limits in both PBS and human whole blood((LoD):1 pg/mL).Our biosensors display similar detection performance in different mediums,demonstrating that our biosensor approach is not limited by Debye screening from salts and can selectively detect biomarkers in physiological fluids.The newly selected enzyme for our platform performs much better performance and longer shelf life which will lead our biosensor platform to be capable for real clinical diagnosis usage.展开更多
Orientation-controlled growth of two-dimensional(2D)transition metal dichalcogenides(TMDCs)may enable many new electronic and optical applications.However,previous studies reporting aligned growth of WSe2 usually yiel...Orientation-controlled growth of two-dimensional(2D)transition metal dichalcogenides(TMDCs)may enable many new electronic and optical applications.However,previous studies reporting aligned growth of WSe2 usually yielded very small domain sizes.Herein,we introduced gold vapor into the chemical vapor deposition(CVD)process as a catalyst to assist the growth of WSe2 and successfully achieved highly aligned monolayer WSe2 triangular flakes grown on c-plane sapphire with large domain sizes(130μm)and fast growth rate(4.3μm·s^−1).When the aligned WSe2 domains merged together,a continuous monolayer WSe2 was formed with good uniformity.After transferring to Si/SiO2 substrates,field effect transistors were fabricated on the continuous monolayer WSe2,and an average mobility of 12 cm^2·V^−1·s−1 was achieved,demonstrating the good quality of the material.This report paves the way to study the effect of catalytic metal vapor in the CVD process of TMDCs and contributes a novel approach to realize the growth of aligned TMDC flakes.展开更多
Carbon nanotubes(CNTs)are ideal candidates for beyond-silicon nano-electronics because of their high mobility and low-cost processing.Recently,assembled massively aligned CNTs have emerged as an important platform for...Carbon nanotubes(CNTs)are ideal candidates for beyond-silicon nano-electronics because of their high mobility and low-cost processing.Recently,assembled massively aligned CNTs have emerged as an important platform for semiconductor electronics.However,realizing sophisticated complementary nano-electronics has been challenging due to the p-type nature of carbon nanotubes in air.Fabrication of n-type behavior field effect transistors(FETs)based on assembled aligned CNT arrays is needed for advanced CNT electronics.Here in this paper,we report a scalable process to make n-type behavior FETs based on assembled aligned CNT arrays.Air-stable and high-performance n-type behavior CNT FETs are achieved with high yield by combining the atomic layer deposition dielectric and metal contact engineering.We also systematically studied the contribution of metal contacts and atomic layer deposition passivation in determining the transistor polarity.Based on these experimental results,we report the successful demonstration of complementary metal-oxide-semiconductor inverters with good performance,which paves the way for realizing the promising future of carbon nanotube nano-electronics.展开更多
文摘In order to build a high-quality team of teachers in vocational higher education institutions, and investigate the current situation of teachers of common required courses in vocational higher education institutions of Hainan Province, an empirical research is conducted. A questionnaire survey was carried out in aspects of satisfaction of teaching and scientific research, professional quality, work saturation and teacher’s job satisfaction. The research results shows that the professional quality of teachers of common required courses cannot significantly influence the satisfaction of teaching and scientific research;Job saturation can positively influence teaching and research satisfaction;teaching and research satisfaction can positively influence teachers’ job satisfaction.
基金the National Natural Science Foundation of China(81788101)the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-022)+1 种基金the 111 Project(BP0820029)the CAMS Endowment Fund(2021-CAMSJZ001)。
文摘Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeutic agents for various diseases.In the present study,we aimed to demonstrate that a herbal small RNA(s RNA),XKC-sRNA-h3(B55710460,F221.I000082.B11),exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme(ACE)in mice.When compared with captopril,oral administration of the sphingosine(d18:1)-XKC-s RNA-h3 bencaosome more effectively prevented angiotensin II-induced hypertensive cardiac damage and alleviated kidney injury in mice.Such findings indicated that XKC-sRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension.
文摘Quasi-two-dimensi on al(2D)β-Ga2O3 is a rediscovered metal-oxide semiconductor with an ultra-wide bandgap of 4.6-4.9eV.It has been reported to be a promising material for next-generation power and radio frequency electronics.Field effect transistors(FETs)that can switch at high voltage are key compone nts in power and radio frequency devices,and reliable Ohmic con tacts are essential for high FET performance.However,obtaining low contact resistance onβ-Ga2O3 FETs is difficult since reactions betweenβ-Ga2O3 and metal contacts are not fully understood.Herein,we experimentally demonstrate the importanee of reactions at the metal/β-Ga2O3 interface and the corresponding effects of these reactions on FET performance.When Ti is employed as the metal contact,annealing ofβ-Ga2O3 FETs in argon can effectively transform Schottky contacts into Ohmic contacts and permit a large drain current density of-3.1 mA//μm.The contact resistance(Rcontact)between the Ti electrodes andβ-Ga2O3 decreased from^430 to^0.387Ω·mm after annealing.X-ray photoelectron spectroscopy(XPS)confirmed the formation of oxygen vacancies at the Ti/β-Ga2O3 interface after annealing,which is believed to cause the improved FET performance.The results of this study pave the way for greater application ofβ-Ga2O3 in electronics.
基金We would like to acknowledge the financial support of this research by King Abdul-Aziz City for ScienceTechnology(KACST)through The Center of Excellence for Nanotechnologies(CEGN).
文摘Developing convenient and accurate SARS-CoV-2 antigen test and serology test is crucial in curbing the global COVID-19 pandemic.In this work,we report an improved indium oxide(In2O3)nanoribbon field-effect transistor(FET)biosensor platform detecting both SARS-CoV-2 antigen and antibody.Our FET biosensors,which were fabricated using a scalable and cost-efficient lithography-free process utilizing shadow masks,consist of an In_(2)O_(3)channel and a newly developed stable enzyme reporter.During the biosensing process,the phosphatase enzymatic reaction generated pH change of the solution,which was then detected and converted to electrical signal by our In_(2)O_(3)FETs.The biosensors applied phosphatase as enzyme reporter,which has a much better stability than the widely used urease in FET based biosensors.As proof-of-principle studies,we demonstrate the detection of SARS-CoV-2 spike protein in both phosphate-buffered saline(PBS)buffer and universal transport medium(UTM)(limit of detection[LoD]:100 fg/mL).Following the SARS-CoV-2 antigen tests,we developed and characterized additional sensors aimed at SARS-CoV-2 IgG antibodies,which is important to trace past infection and vaccination.Our spike protein IgG antibody tests exhibit excellent detection limits in both PBS and human whole blood((LoD):1 pg/mL).Our biosensors display similar detection performance in different mediums,demonstrating that our biosensor approach is not limited by Debye screening from salts and can selectively detect biomarkers in physiological fluids.The newly selected enzyme for our platform performs much better performance and longer shelf life which will lead our biosensor platform to be capable for real clinical diagnosis usage.
文摘Orientation-controlled growth of two-dimensional(2D)transition metal dichalcogenides(TMDCs)may enable many new electronic and optical applications.However,previous studies reporting aligned growth of WSe2 usually yielded very small domain sizes.Herein,we introduced gold vapor into the chemical vapor deposition(CVD)process as a catalyst to assist the growth of WSe2 and successfully achieved highly aligned monolayer WSe2 triangular flakes grown on c-plane sapphire with large domain sizes(130μm)and fast growth rate(4.3μm·s^−1).When the aligned WSe2 domains merged together,a continuous monolayer WSe2 was formed with good uniformity.After transferring to Si/SiO2 substrates,field effect transistors were fabricated on the continuous monolayer WSe2,and an average mobility of 12 cm^2·V^−1·s−1 was achieved,demonstrating the good quality of the material.This report paves the way to study the effect of catalytic metal vapor in the CVD process of TMDCs and contributes a novel approach to realize the growth of aligned TMDC flakes.
基金support from National Science Foundation(NSF)via SNM-IS Award(No.1727523)。
文摘Carbon nanotubes(CNTs)are ideal candidates for beyond-silicon nano-electronics because of their high mobility and low-cost processing.Recently,assembled massively aligned CNTs have emerged as an important platform for semiconductor electronics.However,realizing sophisticated complementary nano-electronics has been challenging due to the p-type nature of carbon nanotubes in air.Fabrication of n-type behavior field effect transistors(FETs)based on assembled aligned CNT arrays is needed for advanced CNT electronics.Here in this paper,we report a scalable process to make n-type behavior FETs based on assembled aligned CNT arrays.Air-stable and high-performance n-type behavior CNT FETs are achieved with high yield by combining the atomic layer deposition dielectric and metal contact engineering.We also systematically studied the contribution of metal contacts and atomic layer deposition passivation in determining the transistor polarity.Based on these experimental results,we report the successful demonstration of complementary metal-oxide-semiconductor inverters with good performance,which paves the way for realizing the promising future of carbon nanotube nano-electronics.