Breeding and Cultivation Techniques for New Edible Orange-Fleshed Sweet Potato Variety Nanshu 012

The carotenoid in sweet potato has a high health value for the human body,and Harvest Plus has also carried out the breeding to improve the nutritional quality of sweet potatoes in order to address the health problems of people nutrient-deficient areas.Nanshu 012 is a new high-quality orange-fleshed sweet potato variety rich in carotenoid,bred by Nanchong Academy of Agricultural Sciences from the " Boga × Sanheshu" hybrid.In the regional test of sweet potato varieties in Sichuan Province during 2009-2010,the average fresh potato yield was 24600 kg/ha,the average dry matter percentage was 29.0 % and the average preserved sweet potato yield was 7152.0 kg/ha;in the production test,the average fresh potato yield was 28410.0 kg/ha and the average preserved sweet potato yield was 8734.5 kg/ha.The multi-point sampling analysis showed that the total sugar content of fresh potato was 5.28 %,protein content was 1.43 %,vitamin C content was 28.9 mg/100 g and carotenoid content was 5.21 mg/100 g.This variety was identified by Sichuan Crop Variety Approval Committee in March 2012,with high fresh potato yield,sweetness,rich carotenoid and resistance to black spot.It is an orange-fleshed sweet potato variety suitable for eating and food processing,and it should be planted in the plot with moderate fertility or above,and should be planted and harvested as early as possible.

Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease:Prospective cohort study and genetic analyses

Background:While type 2 diabetes mellitus(T2DM)is considered a putative causal risk factor for coronary artery disease(CAD),the intrinsic link underlying T2DM and CAD is not fully understood.We aimed to highlight the importance of integrated care targeting both diseases by investigating the phenotypic and genetic relationships between T2DM and CAD.Methods:We evaluated phenotypic associations using data from the United Kingdom Biobank(N=472,050).We investigated genetic relationships by leveraging genomic data conducted in European ancestry for T2DM,with and without adjustment for body mass index(BMI)(T2DM:N_(case)/N_(control)=74,124/824,006;T2DM adjusted for BMI[T2DM_(adj)BMI]:N_(case)/N_(control)=50,409/523,897)and for CAD(N_(case)/N_(control)=181,522/984,168).We performed additional analyses using genomic data conducted in multiancestry individuals for T2DM(N_(case)/N_(control)=180,834/1,159,055).Results:Observational analysis suggested a bidirectional relationship between T2DM and CAD(T2DM→CAD:hazard ratio[HR]=2.12,95%confidence interval[CI]:2.01–2.24;CAD→T2DM:HR=1.72,95%CI:1.63–1.81).A positive overall genetic correlation between T2DM and CAD was observed(r_(g)=0.39,P=1.43×10^(-75)),which was largely independent of BMI(T2DM_(adj)BMI–CAD:r_(g)=0.31,P=1.20×10^(–36)).This was corroborated by six local signals,among which 9p21.3 showed the strongest genetic correlation.Cross-trait meta-analysis replicated 101 previously reported loci and discovered six novel pleiotropic loci.Mendelian randomization analysis supported a bidirectional causal relationship(T2DM→CAD:odds ratio[OR]=1.13,95%CI:1.11-1.16;CAD→T2DM:OR=1.12,95%CI:1.07-1.18),which was confirmed in multiancestry individuals(T2DM→CAD:OR=1.13,95%CI:1.10-1.16;CAD→T2DM:OR=1.08,95%CI:1.04-1.13).This bidirectional relationship was significantly mediated by systolic blood pressure and intake of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors,with mediation proportions of 54.1%(95%CI:24.9-83.4%)and 90.4%(95%CI:29.3-151.5%),respectively.Conclusion:Our observational and genetic analyses demonstrated an intrinsic bidirectional relationship between T2DM and CAD and clarified the biological mechanisms underlying this relationship.