目的:利用网络药理学和分子对接技术对四鲜汤治疗急性白血病(AcuteLeukemia,AL)的作用机制进行研究。方法:通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCM...目的:利用网络药理学和分子对接技术对四鲜汤治疗急性白血病(AcuteLeukemia,AL)的作用机制进行研究。方法:通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、中药分子机制生物信息学分析工具(Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine,BATMAN—TCM)和中医药百科全书数据库(Encyclopedia of Traditional Chinese Medicine,ETCM)检索并获取鲜药复方四鲜汤组方中药(生地、白茅根、小蓟、蒲公英)的化学成分,建立鲜药复方-四鲜汤的天然药物活性化学成分数据集;检索人类基因数据库(Human Gene Data Base,Gencards)、人类疾病相关基因和变异的信息的数据库(Database of Gene-Disease Associations,DisGeNET)、在线生物信息学和化学信息学数据库(Database for Drug and Drug Target Info,DrugBank)、人类疾病数据库(Human Disease Database,MalaCards)以获得AL疾病相关靶点,建立疾病靶点数据库。获取药物以及疾病的交集靶点后,在线画出两者共同靶点venn图;利用String11.5平台构建药物疾病蛋白互作网络;利用cytoscape3.8.2软件构建“药物—疾病—靶点—信号通路”网络,获取相关靶点网络拓扑参数。结果:经TcMSp\BAT-MAN—TcM和ETcM三个数据库检索,获得四鲜汤活性成分30个,相关靶点677个;通过Gencards、DrugBank、MalaCards和DisGeNET四个数据库获得12110个AL疾病潜在靶点;通过R4.2.2平台的ClusterProfiler软件包获得生物功能富集(Gene Ontology,GO)信息条目1011条,其中生物过程(Biological Process,BP)467条,分子功能(Molecular Function,MF)236条,细胞组分(Cellular Component,CC)308条;获得富集的京都基因与基因组百科全书(Kyoto Encyclopedia of Genesand Genomes,KEGG)信号通路220条,主要涉及化学致癌受体激活、脂质与动脉粥样硬化、流体剪切力与动脉粥样硬化、前列腺癌、AGE-RAGE信号通路在糖尿病并发症中的作用等;网络拓扑分析发现,四鲜汤治疗AL疾病作用的主要活性成分有γ-氨基丁酸、腺嘌呤核苷、槲皮素、东莨菪碱和蒲公英萜醇等化合物。结论:四鲜汤治疗AL是一种多成分多靶点多信号通路的共同调节过程,网络药理学为阐明四鲜汤治疗AL的作用机理提供了坚实的研究基础。展开更多
Single-point diamond turning (SPDT) is widely used in the machining of infrared materials and metal-based mirrors. Diamond tips can scratch material, replicate the shape of the tip, and create annular turning marks on...Single-point diamond turning (SPDT) is widely used in the machining of infrared materials and metal-based mirrors. Diamond tips can scratch material, replicate the shape of the tip, and create annular turning marks on optical surfaces, which can have unpredictable adverse effects on imaging. In order to predict the effect of turning marks diffraction on the degradation of imaging quality, a model of the influence of SPDT processing parameters on the reduction of system imaging MTF under the influence of ideal grating turning marks diffraction was established. The results show that the depth of the turning mark will lead to the decline of MTF, especially the low frequency information. Finally, a method is proposed to reduce the effect of turning marks diffraction through changing the processing parameters. .展开更多
背景与目的肺癌术后3个月的生活质量在不同手术入路之间的关系尚不明确,本研究旨在对比单孔与多孔胸腔镜肺叶切除术后3个月患者的生活质量。方法收集2021年4月至2021年10月在四川省肿瘤医院胸外科行肺部手术患者的资料,采用欧洲癌症研...背景与目的肺癌术后3个月的生活质量在不同手术入路之间的关系尚不明确,本研究旨在对比单孔与多孔胸腔镜肺叶切除术后3个月患者的生活质量。方法收集2021年4月至2021年10月在四川省肿瘤医院胸外科行肺部手术患者的资料,采用欧洲癌症研究与治疗组织生活质量核心量表C30 (European Organization for Research and Treatment of Cancer quality of life core 30,EORTC QLQ-C30)和肺癌生活质量量表29 (Quality of Life QuestionnaireLung Cancer 29,QLQ-LC29)收集患者的生活质量资料。将基线资料中潜在混杂因素纳入多因素回归模型中校正,比较两组患者术后3个月的生活质量与传统临床结局。结果共纳入130例肺癌患者,男性57例(43.8%),女性73例(56.2%),平均年龄(57.1±9.5)岁。两组患者基线资料中,放置引流管数量具有统计学差异(P<0.001)。经回归模型校正后,在术后3个月时,两组患者全部症状及功能状态评分无明显差异(P均>0.05)。多孔组的手术时间(120.0 min vs 85.0 min,P=0.001)、术后住院时间(6.0 d vs 4.0 d,P=0.020)比单孔组更长,早期>2级并发症发生率(39.0%vs 10.1%,P=0.011)比单孔组更高。结论单孔与多孔胸腔镜肺叶切除术患者在术后3个月时具有相似的生活质量。单孔组在手术时间、术后住院时间及术后早期并发症等传统临床结局指标上可能具有一定的优势。展开更多
The decarboxylative Minisci reaction is a versatile tool for the direct C-H alkylation of heteroarenes,where stoichiometric amounts of oxidants or expensive,precious metal reagents are commonly used.Herein,we reported...The decarboxylative Minisci reaction is a versatile tool for the direct C-H alkylation of heteroarenes,where stoichiometric amounts of oxidants or expensive,precious metal reagents are commonly used.Herein,we reported a photodriven decarboxylative Minisci reaction enabled by a gallium nitride-based heterogeneous photocatalyst under mild conditions.This method can be effectively applied to a broad substrate scope of acids,including primary,secondary,and tertiary carboxylic acids and N-heteroarenes effectively.The practicability and robustness of the approach are demonstrated for the functionalization of biologically active compounds.展开更多
The generation of aromatic benzene,toluene,xylene(BTX)compounds from non-petroleum feedstocks is of particular interest for chemists in the eyes of sustainability.Herein,a novel synthesis of toluene catalyzed by GaN s...The generation of aromatic benzene,toluene,xylene(BTX)compounds from non-petroleum feedstocks is of particular interest for chemists in the eyes of sustainability.Herein,a novel synthesis of toluene catalyzed by GaN semiconductor nanowire arrays is reported.Using methane and methanol as starting materials,the GaN nanowire arrays can synergistically facilitate the facile generation of toluene under either photo-irradiation or thermal-conditions.The detailed computational studies unveiled different mechanisms involved for the photo-and thermal-toluene synthesis.展开更多
This paper focuses on control design and synthesize for a class of magnetic levitation systems,which have a decentralized control for each suspension point.Due to the existence of mechanical coupling among four suspen...This paper focuses on control design and synthesize for a class of magnetic levitation systems,which have a decentralized control for each suspension point.Due to the existence of mechanical coupling among four suspension points,large modeling uncertainties,unpredictable disturbances during the operation,and measurement noises,becomes challenging.To estimate and compensate for the effects of lumped uncertainties,this study employs the extended state observer(ESO)in conjunction with active disturbance rejection control(ADRC).Specifically,a novel ESO is proposed that utilizes output signals and their derivatives to estimate the lumped uncertainties more accurately,which simplifies the convergence proof conditions and has well engineering performance.This article is written in honor of B.M.Chen on the occasion of his 60th birthday.Specifically,this paper is inspired by his pioneering work on composite nonlinear feedback,which combines linear feedback and nonlinear compensator to enhance system performance Chen et al.(IEEE Trans Autom Control,40:427-439,2003).展开更多
文摘目的:利用网络药理学和分子对接技术对四鲜汤治疗急性白血病(AcuteLeukemia,AL)的作用机制进行研究。方法:通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、中药分子机制生物信息学分析工具(Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine,BATMAN—TCM)和中医药百科全书数据库(Encyclopedia of Traditional Chinese Medicine,ETCM)检索并获取鲜药复方四鲜汤组方中药(生地、白茅根、小蓟、蒲公英)的化学成分,建立鲜药复方-四鲜汤的天然药物活性化学成分数据集;检索人类基因数据库(Human Gene Data Base,Gencards)、人类疾病相关基因和变异的信息的数据库(Database of Gene-Disease Associations,DisGeNET)、在线生物信息学和化学信息学数据库(Database for Drug and Drug Target Info,DrugBank)、人类疾病数据库(Human Disease Database,MalaCards)以获得AL疾病相关靶点,建立疾病靶点数据库。获取药物以及疾病的交集靶点后,在线画出两者共同靶点venn图;利用String11.5平台构建药物疾病蛋白互作网络;利用cytoscape3.8.2软件构建“药物—疾病—靶点—信号通路”网络,获取相关靶点网络拓扑参数。结果:经TcMSp\BAT-MAN—TcM和ETcM三个数据库检索,获得四鲜汤活性成分30个,相关靶点677个;通过Gencards、DrugBank、MalaCards和DisGeNET四个数据库获得12110个AL疾病潜在靶点;通过R4.2.2平台的ClusterProfiler软件包获得生物功能富集(Gene Ontology,GO)信息条目1011条,其中生物过程(Biological Process,BP)467条,分子功能(Molecular Function,MF)236条,细胞组分(Cellular Component,CC)308条;获得富集的京都基因与基因组百科全书(Kyoto Encyclopedia of Genesand Genomes,KEGG)信号通路220条,主要涉及化学致癌受体激活、脂质与动脉粥样硬化、流体剪切力与动脉粥样硬化、前列腺癌、AGE-RAGE信号通路在糖尿病并发症中的作用等;网络拓扑分析发现,四鲜汤治疗AL疾病作用的主要活性成分有γ-氨基丁酸、腺嘌呤核苷、槲皮素、东莨菪碱和蒲公英萜醇等化合物。结论:四鲜汤治疗AL是一种多成分多靶点多信号通路的共同调节过程,网络药理学为阐明四鲜汤治疗AL的作用机理提供了坚实的研究基础。
文摘Single-point diamond turning (SPDT) is widely used in the machining of infrared materials and metal-based mirrors. Diamond tips can scratch material, replicate the shape of the tip, and create annular turning marks on optical surfaces, which can have unpredictable adverse effects on imaging. In order to predict the effect of turning marks diffraction on the degradation of imaging quality, a model of the influence of SPDT processing parameters on the reduction of system imaging MTF under the influence of ideal grating turning marks diffraction was established. The results show that the depth of the turning mark will lead to the decline of MTF, especially the low frequency information. Finally, a method is proposed to reduce the effect of turning marks diffraction through changing the processing parameters. .
文摘背景与目的肺癌术后3个月的生活质量在不同手术入路之间的关系尚不明确,本研究旨在对比单孔与多孔胸腔镜肺叶切除术后3个月患者的生活质量。方法收集2021年4月至2021年10月在四川省肿瘤医院胸外科行肺部手术患者的资料,采用欧洲癌症研究与治疗组织生活质量核心量表C30 (European Organization for Research and Treatment of Cancer quality of life core 30,EORTC QLQ-C30)和肺癌生活质量量表29 (Quality of Life QuestionnaireLung Cancer 29,QLQ-LC29)收集患者的生活质量资料。将基线资料中潜在混杂因素纳入多因素回归模型中校正,比较两组患者术后3个月的生活质量与传统临床结局。结果共纳入130例肺癌患者,男性57例(43.8%),女性73例(56.2%),平均年龄(57.1±9.5)岁。两组患者基线资料中,放置引流管数量具有统计学差异(P<0.001)。经回归模型校正后,在术后3个月时,两组患者全部症状及功能状态评分无明显差异(P均>0.05)。多孔组的手术时间(120.0 min vs 85.0 min,P=0.001)、术后住院时间(6.0 d vs 4.0 d,P=0.020)比单孔组更长,早期>2级并发症发生率(39.0%vs 10.1%,P=0.011)比单孔组更高。结论单孔与多孔胸腔镜肺叶切除术患者在术后3个月时具有相似的生活质量。单孔组在手术时间、术后住院时间及术后早期并发症等传统临床结局指标上可能具有一定的优势。
文摘The decarboxylative Minisci reaction is a versatile tool for the direct C-H alkylation of heteroarenes,where stoichiometric amounts of oxidants or expensive,precious metal reagents are commonly used.Herein,we reported a photodriven decarboxylative Minisci reaction enabled by a gallium nitride-based heterogeneous photocatalyst under mild conditions.This method can be effectively applied to a broad substrate scope of acids,including primary,secondary,and tertiary carboxylic acids and N-heteroarenes effectively.The practicability and robustness of the approach are demonstrated for the functionalization of biologically active compounds.
基金the McGill Sustainability Systems Initiative(MSSI),the Natural Science and Engineering Research Council of Canada,FQRNT,Canada Foundation for Innovation,Canada Research Chair program,and the National Natural Science Foundation of China(No.12104313)。
文摘The generation of aromatic benzene,toluene,xylene(BTX)compounds from non-petroleum feedstocks is of particular interest for chemists in the eyes of sustainability.Herein,a novel synthesis of toluene catalyzed by GaN semiconductor nanowire arrays is reported.Using methane and methanol as starting materials,the GaN nanowire arrays can synergistically facilitate the facile generation of toluene under either photo-irradiation or thermal-conditions.The detailed computational studies unveiled different mechanisms involved for the photo-and thermal-toluene synthesis.
基金This work was supported by the Key Project of the National Natural Science Foundation of China(No.52241103).
文摘This paper focuses on control design and synthesize for a class of magnetic levitation systems,which have a decentralized control for each suspension point.Due to the existence of mechanical coupling among four suspension points,large modeling uncertainties,unpredictable disturbances during the operation,and measurement noises,becomes challenging.To estimate and compensate for the effects of lumped uncertainties,this study employs the extended state observer(ESO)in conjunction with active disturbance rejection control(ADRC).Specifically,a novel ESO is proposed that utilizes output signals and their derivatives to estimate the lumped uncertainties more accurately,which simplifies the convergence proof conditions and has well engineering performance.This article is written in honor of B.M.Chen on the occasion of his 60th birthday.Specifically,this paper is inspired by his pioneering work on composite nonlinear feedback,which combines linear feedback and nonlinear compensator to enhance system performance Chen et al.(IEEE Trans Autom Control,40:427-439,2003).
