Unrestrained inflammation is harmful to tissue repair and regeneration.Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in...Unrestrained inflammation is harmful to tissue repair and regeneration.Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation.Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function,but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions.In this study,we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation(early pulpitis as the model)with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo.Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide(E.coli LPS)with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways.Moreover,nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects,attenuating inflammatory conditions in the early stage.Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage,which widens the potential cell types for inflammation regulation.展开更多
In recent years,two-dimensional metal halide perovskites(MHPs)have attracted increased attention for radiation detection and imaging.Their detection efficiencies are almost comparable to three-dimensional(3D)perovskit...In recent years,two-dimensional metal halide perovskites(MHPs)have attracted increased attention for radiation detection and imaging.Their detection efficiencies are almost comparable to three-dimensional(3D)perovskites.Meanwhile,they demonstrate superior stability to 3D perovskites.The pursuit of high-quality,phase-pure and lead-free two-dimensional MHP materials and large-area fabrication capability for x-ray detectors are among the research hotspots.In this review,we first give a brief introduction of the crystallographic structure,optoelectronic characteristics and preparation methods of high-quality two-dimensional perovskites.In addition,we overview the general working principles of direct and indirect x-ray detection processes and the corresponding performance metrics from the perspective of detection and imaging.Furthermore,we provide a comprehensive discussion on the recent advances in 2D perovskite x-ray detectors and imaging devices.Finally,we pinpoint several major obstacles of 2D x-ray detectors that should be overcome in the near future.展开更多
基金This work was supported by National Natural Science Foundation of China(No.81991500,81991501,51903169,and 82170949)Key Research and Development Program of Sichuan Province(2021YFS0057 and 2020YFS0180)+2 种基金China Postdoctoral Science Foundation(2019M663529)Research funding for talents developing,West China Hospital of Stomatology,Sichuan University(RCDWJS2020-17)Research and Development Funding,West China Hosptial of Stomatology,Sichuan University(RD-02-202003 and RD-03-202104).
文摘Unrestrained inflammation is harmful to tissue repair and regeneration.Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation.Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function,but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions.In this study,we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation(early pulpitis as the model)with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo.Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide(E.coli LPS)with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways.Moreover,nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects,attenuating inflammatory conditions in the early stage.Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage,which widens the potential cell types for inflammation regulation.
基金supported by the National Natural Science Foundation of China(22279083)Natural Science Foundation of Guangdong Province(2019A1515010783)+1 种基金Guangzhou Science and Technology Planning Project(202102010443)Songshan Lake Materials Laboratory.
文摘In recent years,two-dimensional metal halide perovskites(MHPs)have attracted increased attention for radiation detection and imaging.Their detection efficiencies are almost comparable to three-dimensional(3D)perovskites.Meanwhile,they demonstrate superior stability to 3D perovskites.The pursuit of high-quality,phase-pure and lead-free two-dimensional MHP materials and large-area fabrication capability for x-ray detectors are among the research hotspots.In this review,we first give a brief introduction of the crystallographic structure,optoelectronic characteristics and preparation methods of high-quality two-dimensional perovskites.In addition,we overview the general working principles of direct and indirect x-ray detection processes and the corresponding performance metrics from the perspective of detection and imaging.Furthermore,we provide a comprehensive discussion on the recent advances in 2D perovskite x-ray detectors and imaging devices.Finally,we pinpoint several major obstacles of 2D x-ray detectors that should be overcome in the near future.
