Dear Editor,Over-activation of the coagulation system in bacterial sepsis leads to disseminated intravascular coagulation(DIC),a lifethreatening pathophysiological syndrome.1 We previously verified that deficiency of ...Dear Editor,Over-activation of the coagulation system in bacterial sepsis leads to disseminated intravascular coagulation(DIC),a lifethreatening pathophysiological syndrome.1 We previously verified that deficiency of the receptor of intracellular lipopolysaccharide,caspase-11,or its upstream,type I interferons(IFNs),significantly reduces endotoxin-mediated pore-forming and phosphatidylserine exposure,which dampens the activity of TF and subsequently the coagulation cascades.展开更多
基金supported by the grant from the National Natural Science Foundation of China(82072152).
文摘Dear Editor,Over-activation of the coagulation system in bacterial sepsis leads to disseminated intravascular coagulation(DIC),a lifethreatening pathophysiological syndrome.1 We previously verified that deficiency of the receptor of intracellular lipopolysaccharide,caspase-11,or its upstream,type I interferons(IFNs),significantly reduces endotoxin-mediated pore-forming and phosphatidylserine exposure,which dampens the activity of TF and subsequently the coagulation cascades.
