To the Editor:Cardiovascular disease(CVD)remains a leading cause of morbidity and mortality globally,with coronary heart disease(CHD)exhibiting the highest mortality rate.Obesity is an important risk factor for cardio...To the Editor:Cardiovascular disease(CVD)remains a leading cause of morbidity and mortality globally,with coronary heart disease(CHD)exhibiting the highest mortality rate.Obesity is an important risk factor for cardiometabolic complication and CVD.Visceral adipose(VA)and subcutaneous adipose(SA)tissues exert differential and possibly opposing effects on cardiometabolic outcomes.展开更多
An antiviral innate immune response involves induction of type I interferons(IFNs)and their subsequent autocrine and paracrine actions,but the underlying regulatory mechanisms are incompletely understood.Here we repor...An antiviral innate immune response involves induction of type I interferons(IFNs)and their subsequent autocrine and paracrine actions,but the underlying regulatory mechanisms are incompletely understood.Here we report that CYLD,a deubiquitinase that specifically digests lysine 63-linked ubiquitin chains,is required for antiviral host defense.Loss of CYLD renders mice considerably more susceptible to infection by vesicular stomatitis virus(VSV).Consistently,CYLD-deficient dendritic cells are more sensitive to VSV infection.This functional defect was not due to lack of type I IFN production but rather because of attenuated IFN receptor signaling.In the absence of CYLD,IFN-b is ineffective in the induction of antiviral genes and protection of cells from viral infection.These findings establish CYLD as a novel regulator of antiviral innate immunity and suggest a role for CYLD in regulating IFN receptor signaling.展开更多
基金supported by a grant from the Key Research and Development Program(No.2016YFC0900604)from the Ministry of Science and Technology of China
文摘To the Editor:Cardiovascular disease(CVD)remains a leading cause of morbidity and mortality globally,with coronary heart disease(CHD)exhibiting the highest mortality rate.Obesity is an important risk factor for cardiometabolic complication and CVD.Visceral adipose(VA)and subcutaneous adipose(SA)tissues exert differential and possibly opposing effects on cardiometabolic outcomes.
基金supported by the National Institutes of Health grant AI064639.
文摘An antiviral innate immune response involves induction of type I interferons(IFNs)and their subsequent autocrine and paracrine actions,but the underlying regulatory mechanisms are incompletely understood.Here we report that CYLD,a deubiquitinase that specifically digests lysine 63-linked ubiquitin chains,is required for antiviral host defense.Loss of CYLD renders mice considerably more susceptible to infection by vesicular stomatitis virus(VSV).Consistently,CYLD-deficient dendritic cells are more sensitive to VSV infection.This functional defect was not due to lack of type I IFN production but rather because of attenuated IFN receptor signaling.In the absence of CYLD,IFN-b is ineffective in the induction of antiviral genes and protection of cells from viral infection.These findings establish CYLD as a novel regulator of antiviral innate immunity and suggest a role for CYLD in regulating IFN receptor signaling.
