<strong>Background:</strong> <span style="font-family:""><span style="font-family:Verdana;">The neonatal mortality rate in the Central African Republic (CAR) is 42.3 pe...<strong>Background:</strong> <span style="font-family:""><span style="font-family:Verdana;">The neonatal mortality rate in the Central African Republic (CAR) is 42.3 per 1000 live births in 2017, indicating that CAR is with the highest number of newborn deaths. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> T</span></span><span style="font-family:Verdana;">he objective is t</span><span style="font-family:""><span style="font-family:Verdana;">o clarify the risk factors of neonatal deaths in this area. </span><b><span style="font-family:Verdana;">Methodology:</span></b><span style="font-family:Verdana;"> A case-control study with retrospective data collection. Targets were newborns >7 days, hospitalized and dead (cases), and newborns admitted after the respective case during the study period and discharged before the 7</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> day of life. This study was carried out between 2016 and 2018 in the neonatal unit of the “Complexe Hospitalier Universitaire Pédiatrique de Bangui” (CHUPB), the only national hospital for newborns care in the CAR. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> We included 902 newborns, with 451 cases of early neonatal death and 451 controls. 4168 newborns were admitted to the neonatology unit with 621 early death cases;a lethality rate of 14.9%. Early neonatal deaths factors were: newborns with low birth weight (OR = 22.59;95% CI [15.93 - 32.04];</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">P < 0.001);mothers who did not attend antenatal care (OR = 5.54;95% CI [3.95 - 7.79];P < 0.001), home delivery (OR = 0.70;95% CI [0.03 - 0.15];P < 0.001);young maternal age <</span><span style="font-family:""> </span><span style="font-family:Verdana;">25 years (OR = 2.08;95% CI [1.58 - 2.73];P < 0.001);non-medical transport (OR = 2.14;95% CI [1.03 - 4.46];P = 0.03);origin from remote areas (OR = 5.25;95% CI [3.95 - 6.98];P < 0.001);isolated prematurity (P <</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.01);anoxo-ischemic encephalopathy (OR = 12.72;95% CI [6.54 - 34.73];P <</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">0.01);delivery by cesarean section (OR = 0.59;95% CI [0.41 - 0.84];P < 0.001);preterm delivery (OR = 29.36;95% CI [20.12 - 42.81];P < 0.001), and maternal lower education (OR = 5.65;95% CI [4.08 - 7.81];P < 0.001). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The early neonatal mortality rate remains high in this area. Controlling the factors mentioned above might lead to improving the survival of newborns.</span></span>展开更多
文摘<strong>Background:</strong> <span style="font-family:""><span style="font-family:Verdana;">The neonatal mortality rate in the Central African Republic (CAR) is 42.3 per 1000 live births in 2017, indicating that CAR is with the highest number of newborn deaths. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> T</span></span><span style="font-family:Verdana;">he objective is t</span><span style="font-family:""><span style="font-family:Verdana;">o clarify the risk factors of neonatal deaths in this area. </span><b><span style="font-family:Verdana;">Methodology:</span></b><span style="font-family:Verdana;"> A case-control study with retrospective data collection. Targets were newborns >7 days, hospitalized and dead (cases), and newborns admitted after the respective case during the study period and discharged before the 7</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> day of life. This study was carried out between 2016 and 2018 in the neonatal unit of the “Complexe Hospitalier Universitaire Pédiatrique de Bangui” (CHUPB), the only national hospital for newborns care in the CAR. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> We included 902 newborns, with 451 cases of early neonatal death and 451 controls. 4168 newborns were admitted to the neonatology unit with 621 early death cases;a lethality rate of 14.9%. Early neonatal deaths factors were: newborns with low birth weight (OR = 22.59;95% CI [15.93 - 32.04];</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">P < 0.001);mothers who did not attend antenatal care (OR = 5.54;95% CI [3.95 - 7.79];P < 0.001), home delivery (OR = 0.70;95% CI [0.03 - 0.15];P < 0.001);young maternal age <</span><span style="font-family:""> </span><span style="font-family:Verdana;">25 years (OR = 2.08;95% CI [1.58 - 2.73];P < 0.001);non-medical transport (OR = 2.14;95% CI [1.03 - 4.46];P = 0.03);origin from remote areas (OR = 5.25;95% CI [3.95 - 6.98];P < 0.001);isolated prematurity (P <</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.01);anoxo-ischemic encephalopathy (OR = 12.72;95% CI [6.54 - 34.73];P <</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">0.01);delivery by cesarean section (OR = 0.59;95% CI [0.41 - 0.84];P < 0.001);preterm delivery (OR = 29.36;95% CI [20.12 - 42.81];P < 0.001), and maternal lower education (OR = 5.65;95% CI [4.08 - 7.81];P < 0.001). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The early neonatal mortality rate remains high in this area. Controlling the factors mentioned above might lead to improving the survival of newborns.</span></span>