Mitochondria are essential organelles that play a central role in cellular metabolism and physiology.Their broad range of functions include supplying energy,regulating signaling pathways,and maintaining control of cel...Mitochondria are essential organelles that play a central role in cellular metabolism and physiology.Their broad range of functions include supplying energy,regulating signaling pathways,and maintaining control of cell proliferation and apoptosis.As defective mitochondria can perturb cellular homeostasis,quality control mechanisms have evolved to preserve mitochondrial fidelity in response to stress and aging(Palikaras et al.,2018).Persistent defects,however,trigger elimination of the entire organelle by an evolutionarily conserved set of cellular processes that specifically remove dysfunctional or surplus mitochondria.This selective degradation of the mitochondria through autophagy,termed mitophagy,is important in fine-tuning mitochondrial number.展开更多
文摘Mitochondria are essential organelles that play a central role in cellular metabolism and physiology.Their broad range of functions include supplying energy,regulating signaling pathways,and maintaining control of cell proliferation and apoptosis.As defective mitochondria can perturb cellular homeostasis,quality control mechanisms have evolved to preserve mitochondrial fidelity in response to stress and aging(Palikaras et al.,2018).Persistent defects,however,trigger elimination of the entire organelle by an evolutionarily conserved set of cellular processes that specifically remove dysfunctional or surplus mitochondria.This selective degradation of the mitochondria through autophagy,termed mitophagy,is important in fine-tuning mitochondrial number.
