Brookline Ave nue, Boston, MA 02215, United States] Background: The association of light to moderate alcohol consumption with ris k for ischemic stroke remains controversial, as do the roles of beverage type an d drin...Brookline Ave nue, Boston, MA 02215, United States] Background: The association of light to moderate alcohol consumption with ris k for ischemic stroke remains controversial, as do the roles of beverage type an d drinking pattern. Objective: To assess the association of drinking patterns an d beverage type with risk for ischemic stroke among men. Design: Prospective coh ort study. Setting: United States. Participants: 38156 male health professionals who were free of known cardiovascular disease or cancer at baseline in 1986. Me asurements: With a semi quantitative food frequency questionnaire, the autho rs individually ascertained consumption of regular and light beer, red and white wine, and liquor every 4 years. Alcohol consumption was categorized as light (0 .1 to 9.9 g/d, or < 1 drink daily), moderate (10.0 to 29.9 g/d, or 1 to 2 drinks daily), and heavier (≥ 30.0 g/d, or ≥ 3 drinks daily). Results: During a foll ow up period of 14 years, 412 cases of incident ischemic stroke were documente d. Compared with abstainers, light drinkers had a multivariate adjusted relati ve risk of 0.99 (95% CI, 0.72 to 1.37), moderate drinkers had a multivariate adjusted relative risk of 1.26 (CI, 0.90 to 1.76), and heavier drinkers had a m ultivariate adjusted relative risk of 1.42 (CI, 0.97 to 2.09; P =0.01 for tren d). Consumption of 10.0 to 29.9 g of alcohol per day on 3 to 4 days per week app eared to be associated with the lowest risk (relative risk, 0.68 [CI, 0.44 to 1. 05]). Red wine consumption was inversely associated with risk in a graded manner (P = 0.02 for trend), but other beverages were not. The apparently higher risk for ischemic stroke with heavier alcohol use appeared to be most pronounced for the embolic subtype. Limitations: This study had limited power to examine specif ic drinking patterns and heavy drinking and could not assess risk for hemorrhagi c stroke. Conclusions: In this sample of male health professionals, light and mo derate average alcohol use was generally not associated with an increased risk f or ischemic stroke, although drinking pattern and beverage type modified this re lation. Intake of more than 2 drinks per day may be associated with a higher ris k for ischemic stroke.展开更多
Objectives: We investigated the association between alcohol consumption and incident congestive heart failure(CHF) both overall and after adjusting for incident myocardial infarction(MI). Background: Moderate alcohol ...Objectives: We investigated the association between alcohol consumption and incident congestive heart failure(CHF) both overall and after adjusting for incident myocardial infarction(MI). Background: Moderate alcohol consumption has been associated with lower risk of CHF and MI. Methods: The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects ≥65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption. Results: There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week(hazard ratio[HR] 0.82, 95%confidence interval[CI] 0.67 to 1.00, p=0.05) and 7 to 13 drinks per week(HR 0.66, 95%CI 0.47 to 0.91, p=0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF(for 1 to 6 drinks per week, HR 0.84, 95%CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95%CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers(HR 1.51, p< 0.01), but those who quit during the study did not have a higher risk(HR 0.83, 95%CI 0.66 to 1.03). Conclusions: Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.展开更多
文摘Brookline Ave nue, Boston, MA 02215, United States] Background: The association of light to moderate alcohol consumption with ris k for ischemic stroke remains controversial, as do the roles of beverage type an d drinking pattern. Objective: To assess the association of drinking patterns an d beverage type with risk for ischemic stroke among men. Design: Prospective coh ort study. Setting: United States. Participants: 38156 male health professionals who were free of known cardiovascular disease or cancer at baseline in 1986. Me asurements: With a semi quantitative food frequency questionnaire, the autho rs individually ascertained consumption of regular and light beer, red and white wine, and liquor every 4 years. Alcohol consumption was categorized as light (0 .1 to 9.9 g/d, or < 1 drink daily), moderate (10.0 to 29.9 g/d, or 1 to 2 drinks daily), and heavier (≥ 30.0 g/d, or ≥ 3 drinks daily). Results: During a foll ow up period of 14 years, 412 cases of incident ischemic stroke were documente d. Compared with abstainers, light drinkers had a multivariate adjusted relati ve risk of 0.99 (95% CI, 0.72 to 1.37), moderate drinkers had a multivariate adjusted relative risk of 1.26 (CI, 0.90 to 1.76), and heavier drinkers had a m ultivariate adjusted relative risk of 1.42 (CI, 0.97 to 2.09; P =0.01 for tren d). Consumption of 10.0 to 29.9 g of alcohol per day on 3 to 4 days per week app eared to be associated with the lowest risk (relative risk, 0.68 [CI, 0.44 to 1. 05]). Red wine consumption was inversely associated with risk in a graded manner (P = 0.02 for trend), but other beverages were not. The apparently higher risk for ischemic stroke with heavier alcohol use appeared to be most pronounced for the embolic subtype. Limitations: This study had limited power to examine specif ic drinking patterns and heavy drinking and could not assess risk for hemorrhagi c stroke. Conclusions: In this sample of male health professionals, light and mo derate average alcohol use was generally not associated with an increased risk f or ischemic stroke, although drinking pattern and beverage type modified this re lation. Intake of more than 2 drinks per day may be associated with a higher ris k for ischemic stroke.
文摘Objectives: We investigated the association between alcohol consumption and incident congestive heart failure(CHF) both overall and after adjusting for incident myocardial infarction(MI). Background: Moderate alcohol consumption has been associated with lower risk of CHF and MI. Methods: The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects ≥65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption. Results: There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week(hazard ratio[HR] 0.82, 95%confidence interval[CI] 0.67 to 1.00, p=0.05) and 7 to 13 drinks per week(HR 0.66, 95%CI 0.47 to 0.91, p=0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF(for 1 to 6 drinks per week, HR 0.84, 95%CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95%CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers(HR 1.51, p< 0.01), but those who quit during the study did not have a higher risk(HR 0.83, 95%CI 0.66 to 1.03). Conclusions: Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.
