Objective To examine whether cardiovascular disease(CVD) is associated with depression status. Methods 29,328 participants from baseline of Canadian Longitudinal Study for Aging were categorized into four groups of de...Objective To examine whether cardiovascular disease(CVD) is associated with depression status. Methods 29,328 participants from baseline of Canadian Longitudinal Study for Aging were categorized into four groups of depression status. Group 1: no depression(reference);Group 2: currently with depression symptom(CES-D10 score ≥ 10, negative self-reported depression);Group 3: self-reported depression with no current symptom(CES-D10 score < 10, positive self-reported depression);and Group 4: self-reported depression with current symptom(CES-D10 score ≥ 10, self-reported depression). Six self-reported CVDs were grouped into two related disorders, i.e., heart related disorders(HRD) including heart disease, myocardial infarction, and angina;and peripheral/vascular related disorders(PRD) including hypertension, stroke, and peripheral vascular disease. Adjusted odds ratios(ORs) were used to evaluate the associations between depression and CVDs. Results 17.3% of participants had self-reported depression, 15.3% were with current depression symptom, 10.5% were with HRD and 34.4% were with PRD. After adjusting for variables of demographics, sex, lifestyles, and comorbidities, compared to reference, people in Group 2 had a slightly increased odds, but most of them were not statistically significant;the ORs(95% CI) were 1.36(1.18–1.58, P < 0.0001) for HRD and 1.20(1.09–1.32, P < 0.001) for PRD in Group 3;for people in Group 4, the ORs(95% CI) were 1.31(1.08–1.61, P < 0.01) for HRD and 1.17(1.02–1.34, P < 0.05) for PRD. Sex-and age-stratified analyses suggested that the increased ORs were more prevalent in men and people aged < 65 years. Conclusions Seniors with self-reported depression are associated with an increased risk of CVDs, the association varies by depression status, sex and age.展开更多
OBJECTIVE To examine whether difficulty of falling asleep(DoFA)is associated with non-high-density lipoprotein cholesterol(non-HDL-C)level among Canadian older adults.METHODS 26,954 individuals aged 45-85 years from t...OBJECTIVE To examine whether difficulty of falling asleep(DoFA)is associated with non-high-density lipoprotein cholesterol(non-HDL-C)level among Canadian older adults.METHODS 26,954 individuals aged 45-85 years from the baseline data of the Canadian Longitudinal Study for Aging were in-cluded in this study.DoFA was categorized into five groups by answer to the question“Over the last month,how often did it take you more than 30 min to fall asleep?”Response options are“Never,<1 time/week,1−2 times/week,3−5 times/week,or 6−7 times/week”.Non-HDL-C,the difference of total cholesterol and HDL-C,were categorized into five categories based on these cut-offs(<2.6 mmol/L,2.6−3.7 mmol/L,3.7−4.8 mmol/L,4.8−5.7 mmol/L,and≥5.7 mmol/L).Ordinal logistic regression(logit link)continuation ratio models were used to estimate the odds of higher non-HDL-C levels for DoFA status.Adjusted means of non-HDL-C by DoFA status were estimated by general linear models.All analyses were sex separately using analytic weights to en-sure generalizability.RESULTS The proportions of DoFA in five categories were 41.6%,25.7%,13.6%,9.4%,9.7%for females and 52.9%,24.9%,10.5%,6.1%,5.6%for males,respectively.After adjustment of demographical and other covariates(such as depression,comorbidity,sleeping hour,etc.)compared to those who reported never having DoFA,the ORs(95%CIs)of higher levels of non-HDL-C for those whose DoFA status in<1 time/week,1−2 times/week,3−5 times/week,and 6−7 times/week were 1.12(1.05−1.21),1.09(0.99−1.18),1.20(1.09−1.33),1.29(1.17−1.43)in females and 1.05(0.98−1.13),0.95(0.87−1.05),1.21(1.08−1.37),0.97(0.85−1.09)in males,respectively.The adjusted means of non-HDL-C among the five DoFA status were 3.68 mmol/L,3.73 mmol/L,3.74 mmol/L,3.82 mmol/L,3.84 mmol/L for females and 3.54 mmol/L,3.58 mmol/L,3.51 mmol/L,3.69 mmol/L,3.54 mmol/L for males,respectively.CONCLUSIONS The results of this study have identified a risk association pattern between DoFA status and non-HDL-C levels in females but not in males.Further research is needed to confirm these findings.展开更多
基金supported by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant (LSA 9447 and the Canada Foundation for Innovation)
文摘Objective To examine whether cardiovascular disease(CVD) is associated with depression status. Methods 29,328 participants from baseline of Canadian Longitudinal Study for Aging were categorized into four groups of depression status. Group 1: no depression(reference);Group 2: currently with depression symptom(CES-D10 score ≥ 10, negative self-reported depression);Group 3: self-reported depression with no current symptom(CES-D10 score < 10, positive self-reported depression);and Group 4: self-reported depression with current symptom(CES-D10 score ≥ 10, self-reported depression). Six self-reported CVDs were grouped into two related disorders, i.e., heart related disorders(HRD) including heart disease, myocardial infarction, and angina;and peripheral/vascular related disorders(PRD) including hypertension, stroke, and peripheral vascular disease. Adjusted odds ratios(ORs) were used to evaluate the associations between depression and CVDs. Results 17.3% of participants had self-reported depression, 15.3% were with current depression symptom, 10.5% were with HRD and 34.4% were with PRD. After adjusting for variables of demographics, sex, lifestyles, and comorbidities, compared to reference, people in Group 2 had a slightly increased odds, but most of them were not statistically significant;the ORs(95% CI) were 1.36(1.18–1.58, P < 0.0001) for HRD and 1.20(1.09–1.32, P < 0.001) for PRD in Group 3;for people in Group 4, the ORs(95% CI) were 1.31(1.08–1.61, P < 0.01) for HRD and 1.17(1.02–1.34, P < 0.05) for PRD. Sex-and age-stratified analyses suggested that the increased ORs were more prevalent in men and people aged < 65 years. Conclusions Seniors with self-reported depression are associated with an increased risk of CVDs, the association varies by depression status, sex and age.
基金the Government of Canada through the Canadian Institutes of Health Research(CLSA 94473)and the Canada Foundation for Innovation.
文摘OBJECTIVE To examine whether difficulty of falling asleep(DoFA)is associated with non-high-density lipoprotein cholesterol(non-HDL-C)level among Canadian older adults.METHODS 26,954 individuals aged 45-85 years from the baseline data of the Canadian Longitudinal Study for Aging were in-cluded in this study.DoFA was categorized into five groups by answer to the question“Over the last month,how often did it take you more than 30 min to fall asleep?”Response options are“Never,<1 time/week,1−2 times/week,3−5 times/week,or 6−7 times/week”.Non-HDL-C,the difference of total cholesterol and HDL-C,were categorized into five categories based on these cut-offs(<2.6 mmol/L,2.6−3.7 mmol/L,3.7−4.8 mmol/L,4.8−5.7 mmol/L,and≥5.7 mmol/L).Ordinal logistic regression(logit link)continuation ratio models were used to estimate the odds of higher non-HDL-C levels for DoFA status.Adjusted means of non-HDL-C by DoFA status were estimated by general linear models.All analyses were sex separately using analytic weights to en-sure generalizability.RESULTS The proportions of DoFA in five categories were 41.6%,25.7%,13.6%,9.4%,9.7%for females and 52.9%,24.9%,10.5%,6.1%,5.6%for males,respectively.After adjustment of demographical and other covariates(such as depression,comorbidity,sleeping hour,etc.)compared to those who reported never having DoFA,the ORs(95%CIs)of higher levels of non-HDL-C for those whose DoFA status in<1 time/week,1−2 times/week,3−5 times/week,and 6−7 times/week were 1.12(1.05−1.21),1.09(0.99−1.18),1.20(1.09−1.33),1.29(1.17−1.43)in females and 1.05(0.98−1.13),0.95(0.87−1.05),1.21(1.08−1.37),0.97(0.85−1.09)in males,respectively.The adjusted means of non-HDL-C among the five DoFA status were 3.68 mmol/L,3.73 mmol/L,3.74 mmol/L,3.82 mmol/L,3.84 mmol/L for females and 3.54 mmol/L,3.58 mmol/L,3.51 mmol/L,3.69 mmol/L,3.54 mmol/L for males,respectively.CONCLUSIONS The results of this study have identified a risk association pattern between DoFA status and non-HDL-C levels in females but not in males.Further research is needed to confirm these findings.
