OBJECTIVE: To assess the efficacy and safety of Yunxiangjing(YXJ), derived from Chinese herbal medicine, in the management of acute radiation-induced proctitis(ARIP) in patients with pelvic malignancy.METHODS: Forty-e...OBJECTIVE: To assess the efficacy and safety of Yunxiangjing(YXJ), derived from Chinese herbal medicine, in the management of acute radiation-induced proctitis(ARIP) in patients with pelvic malignancy.METHODS: Forty-eight patients with grade 2 ARIP were administered YXJ as an enema(1∶30 dilution)for 2 weeks and followed up for 2 years. All were assessed for response and ARIP grade. Quality of life(QOL) was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30.RESULTS: Of the 48 patients, six(12.5%) achieved complete remission of ARIP and 28(58.3%) showed a decrease from grade 2 to grade 1 ARIP. No patient experienced a grade ≥3 toxicity. At the end of radiotherapy, patients showed significant improvements in QOL(P < 0.05). Two years after treatment, 46 patients showed no late toxicity, with only two experiencing grade 1 late toxicity.CONCLUSION: YXJ can be used as an enema to manage acute radiation-induced proctitis in cancer patients undergoing radiotherapy. These findings suggest that YXJ enema may be an alternative treatment of ARIP.展开更多
基金Supported by the Scientific Research Fund of the Administration of Traditional Chinese Medicine of Guangxi Province of China:The clinical trial of Chinese Herbal Formula Yunxiangjing Enemas on the treatment of Acute Radiation-Induced Proctitis(No.gzzc 1165)
文摘OBJECTIVE: To assess the efficacy and safety of Yunxiangjing(YXJ), derived from Chinese herbal medicine, in the management of acute radiation-induced proctitis(ARIP) in patients with pelvic malignancy.METHODS: Forty-eight patients with grade 2 ARIP were administered YXJ as an enema(1∶30 dilution)for 2 weeks and followed up for 2 years. All were assessed for response and ARIP grade. Quality of life(QOL) was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30.RESULTS: Of the 48 patients, six(12.5%) achieved complete remission of ARIP and 28(58.3%) showed a decrease from grade 2 to grade 1 ARIP. No patient experienced a grade ≥3 toxicity. At the end of radiotherapy, patients showed significant improvements in QOL(P < 0.05). Two years after treatment, 46 patients showed no late toxicity, with only two experiencing grade 1 late toxicity.CONCLUSION: YXJ can be used as an enema to manage acute radiation-induced proctitis in cancer patients undergoing radiotherapy. These findings suggest that YXJ enema may be an alternative treatment of ARIP.
