Background and Aims:Non-Hodgkin lymphoma (NHL) of the liver is a rare lymphoid malignancy,accounting for less than 1% of extranodal lymphomas.Methods:I conducted an analysis of the U.S Surveillance,Epidemiology,and En...Background and Aims:Non-Hodgkin lymphoma (NHL) of the liver is a rare lymphoid malignancy,accounting for less than 1% of extranodal lymphomas.Methods:I conducted an analysis of the U.S Surveillance,Epidemiology,and End Results (SEER) database to evaluate the histological subtypes and the survival outcomes of 785 cases with hepatic NHL between 1973 and 2012.Results:There were 785 of 312 459 cases with NHL had a first primary hepatic NHL (0.25%).Of the total 785 cases,the median age at diagnosis was 61 years (range 3-95 years) and male-female ratio of 1.7∶1.The most common subtype was diffuse large B cell lymphoma (63.2%).In all patients,the median overall survival (OS) was 33 months (95%CI,22-48 months).The 5-year OS rate for indolent B-cell NHLs was 62%,compared with 44% for an aggressive B-cell NHLs and 42% for T-cell NHLs.The median OS improved from 19 months in patients diagnosed in a period 1996-2000 to 60 months when diagnosed between 2006 and 2012 (p <.001).In a multivariable Cox regression analysis,the age ≥80 years (adjusted hazard ratio [aHR] 3.21,p <.001),male gender (aHR 1.26,p =.02),Black race (aHR,1.70,p <.001),and T-cell NHLvariants (aHR 1.73,p =.03) were unfavourable prognostic factors.Conclusion:NHL of the liver comprises about 0.3% of all NHLs and survival was improved in the recent calendar period.展开更多
文摘Background and Aims:Non-Hodgkin lymphoma (NHL) of the liver is a rare lymphoid malignancy,accounting for less than 1% of extranodal lymphomas.Methods:I conducted an analysis of the U.S Surveillance,Epidemiology,and End Results (SEER) database to evaluate the histological subtypes and the survival outcomes of 785 cases with hepatic NHL between 1973 and 2012.Results:There were 785 of 312 459 cases with NHL had a first primary hepatic NHL (0.25%).Of the total 785 cases,the median age at diagnosis was 61 years (range 3-95 years) and male-female ratio of 1.7∶1.The most common subtype was diffuse large B cell lymphoma (63.2%).In all patients,the median overall survival (OS) was 33 months (95%CI,22-48 months).The 5-year OS rate for indolent B-cell NHLs was 62%,compared with 44% for an aggressive B-cell NHLs and 42% for T-cell NHLs.The median OS improved from 19 months in patients diagnosed in a period 1996-2000 to 60 months when diagnosed between 2006 and 2012 (p <.001).In a multivariable Cox regression analysis,the age ≥80 years (adjusted hazard ratio [aHR] 3.21,p <.001),male gender (aHR 1.26,p =.02),Black race (aHR,1.70,p <.001),and T-cell NHLvariants (aHR 1.73,p =.03) were unfavourable prognostic factors.Conclusion:NHL of the liver comprises about 0.3% of all NHLs and survival was improved in the recent calendar period.
