Routing is a key function inWireless Sensor Networks(WSNs)since it facilitates data transfer to base stations.Routing attacks have the potential to destroy and degrade the functionality ofWSNs.A trustworthy routing sy...Routing is a key function inWireless Sensor Networks(WSNs)since it facilitates data transfer to base stations.Routing attacks have the potential to destroy and degrade the functionality ofWSNs.A trustworthy routing system is essential for routing security andWSN efficiency.Numerous methods have been implemented to build trust between routing nodes,including the use of cryptographic methods and centralized routing.Nonetheless,the majority of routing techniques are unworkable in reality due to the difficulty of properly identifying untrusted routing node activities.At the moment,there is no effective way to avoid malicious node attacks.As a consequence of these concerns,this paper proposes a trusted routing technique that combines blockchain infrastructure,deep neural networks,and Markov Decision Processes(MDPs)to improve the security and efficiency of WSN routing.To authenticate the transmission process,the suggested methodology makes use of a Proof of Authority(PoA)mechanism inside the blockchain network.The validation group required for proofing is chosen using a deep learning approach that prioritizes each node’s characteristics.MDPs are then utilized to determine the suitable next-hop as a forwarding node capable of securely transmitting messages.According to testing data,our routing system outperforms current routing algorithms in a 50%malicious node routing scenario.展开更多
Over the past decade, a multitude of molecular targeted agents have been explored in the treatment of advanced metastatic gastric. Recent advances in molecular signaling pathways that are dysregulated in gastric cance...Over the past decade, a multitude of molecular targeted agents have been explored in the treatment of advanced metastatic gastric. Recent advances in molecular signaling pathways that are dysregulated in gastric cancer lead to the development of new targeted therapies for the treatment of advanced and metastatic gastric cancer. The addition of trastuzumab to first-line chemotherapy is now a standard of care for the treatment of Human epidermal growth factor receptor (HER2-) positive advanced or metastatic disease, and other HER2-targeted therapies are in late-stage clinical development. Findings from recent major clinical trials provide important insight into the future of metastatic gastric cancer management, which may include the use of anti-angiogenesis, Mesenchymal epithelial transition factor (MET) and Hedgehog Pathways Inhibitortherapy across multiple treatment lines, in the salvage setting, and as part of novel regimens in combination with other targeted agents.展开更多
A novel water treatment technique, based on a combination of electrospraying and pulsed corona discharge, has been used for bio-decontamination of wastewater. The electrospraying process has been found to increase the...A novel water treatment technique, based on a combination of electrospraying and pulsed corona discharge, has been used for bio-decontamination of wastewater. The electrospraying process has been found to increase the surface area of the treated wastewater, and hence increases the efficiency of the corona treatment process. The phase diagram of the discharge, which characterizes the discharge regimes, has been identified experimentally. The survival ratio of the microorganisms has been investigated experimentally as a function of the applied voltage and the numbers of treatment runs using air and oxygen as working gases. Microorganism surface has been examined using scanning electron microscope (SEM), which enabled in understanding the decontamination mechanisms of the treated microorganism. A complete decontamination has been achieved after only one run for an applied voltage higher than 16 kV when the discharge system was operated in oxygen gas. Optical emission spectrum of the electrosprayed water confirmed the existence of OH-radicals responsible for decontamination process.展开更多
Background: Recent evidence for the effects of vitamin D and recognition of the high prevalence of its deficiency has increased the interest in it. Vitamin D-sub nutrition may contribute to the risk of a wide range of...Background: Recent evidence for the effects of vitamin D and recognition of the high prevalence of its deficiency has increased the interest in it. Vitamin D-sub nutrition may contribute to the risk of a wide range of disorders. Methods: The females in the child-bearing period attending the endocrinology and orthopedic out-patient clinics complaining of pain and/or tenderness at the groin were evaluated. Patients with chronic metabolic or skeletal illness, primary hyperparathyroidism, and patients receiving drugs that interfere with bone mineral metabolisms were excluded. One hundred accepted and consented to participation in the study. All the participants were subjected to full history taking, clinical evaluation, laboratory investigations including serum Ca, Ph, PTH, ALP, TSH, F T4, F T3, Cortisol level, and 25(OH)D level. Plain X-ray was done for the regions of bony tenderness. The subjects were divided into 2 groups based on the presence or absence of pseudo-fractures (looser zones). They were treated and followed up till normalization of the laboratory parameters and healing of the looser zones. Results: The mean age for patients was 30.45 ± 5.8, their mean 25(OH) vitamin D level was 14.7 ± 5.9 ng/ml, the mean PTH was 195.7 ± 162.6, and looser zones were evident in the X-rays of 34 patients. The serum 25(OH)D showed significant negative correlations with veiling, parity, localized hip pain, and tenderness, ALP, PTH, but, a significant positive correlation with sun exposure, dairy products consumption, vitamin D supplementation, and serum calcium levels. The independent factors associated with hypovitaminosis D were the lack of sun exposure, lack of vitamin D supplementation, and the presence of pseudo- fracture (p ≤ 0.009, 0.038, and 0.001 respectively). No surgery was required in any of our patients. Conclusions: Vitamin D deficiency is common in our region. The main risk factors are decreased sun exposure, low dairy products consumption, and lack of vitamin D supplementation. Successful medical treatment may be helpful to satisfy the patient, avoid true fracture and further major surgical treatments.展开更多
文摘Routing is a key function inWireless Sensor Networks(WSNs)since it facilitates data transfer to base stations.Routing attacks have the potential to destroy and degrade the functionality ofWSNs.A trustworthy routing system is essential for routing security andWSN efficiency.Numerous methods have been implemented to build trust between routing nodes,including the use of cryptographic methods and centralized routing.Nonetheless,the majority of routing techniques are unworkable in reality due to the difficulty of properly identifying untrusted routing node activities.At the moment,there is no effective way to avoid malicious node attacks.As a consequence of these concerns,this paper proposes a trusted routing technique that combines blockchain infrastructure,deep neural networks,and Markov Decision Processes(MDPs)to improve the security and efficiency of WSN routing.To authenticate the transmission process,the suggested methodology makes use of a Proof of Authority(PoA)mechanism inside the blockchain network.The validation group required for proofing is chosen using a deep learning approach that prioritizes each node’s characteristics.MDPs are then utilized to determine the suitable next-hop as a forwarding node capable of securely transmitting messages.According to testing data,our routing system outperforms current routing algorithms in a 50%malicious node routing scenario.
文摘Over the past decade, a multitude of molecular targeted agents have been explored in the treatment of advanced metastatic gastric. Recent advances in molecular signaling pathways that are dysregulated in gastric cancer lead to the development of new targeted therapies for the treatment of advanced and metastatic gastric cancer. The addition of trastuzumab to first-line chemotherapy is now a standard of care for the treatment of Human epidermal growth factor receptor (HER2-) positive advanced or metastatic disease, and other HER2-targeted therapies are in late-stage clinical development. Findings from recent major clinical trials provide important insight into the future of metastatic gastric cancer management, which may include the use of anti-angiogenesis, Mesenchymal epithelial transition factor (MET) and Hedgehog Pathways Inhibitortherapy across multiple treatment lines, in the salvage setting, and as part of novel regimens in combination with other targeted agents.
文摘A novel water treatment technique, based on a combination of electrospraying and pulsed corona discharge, has been used for bio-decontamination of wastewater. The electrospraying process has been found to increase the surface area of the treated wastewater, and hence increases the efficiency of the corona treatment process. The phase diagram of the discharge, which characterizes the discharge regimes, has been identified experimentally. The survival ratio of the microorganisms has been investigated experimentally as a function of the applied voltage and the numbers of treatment runs using air and oxygen as working gases. Microorganism surface has been examined using scanning electron microscope (SEM), which enabled in understanding the decontamination mechanisms of the treated microorganism. A complete decontamination has been achieved after only one run for an applied voltage higher than 16 kV when the discharge system was operated in oxygen gas. Optical emission spectrum of the electrosprayed water confirmed the existence of OH-radicals responsible for decontamination process.
文摘Background: Recent evidence for the effects of vitamin D and recognition of the high prevalence of its deficiency has increased the interest in it. Vitamin D-sub nutrition may contribute to the risk of a wide range of disorders. Methods: The females in the child-bearing period attending the endocrinology and orthopedic out-patient clinics complaining of pain and/or tenderness at the groin were evaluated. Patients with chronic metabolic or skeletal illness, primary hyperparathyroidism, and patients receiving drugs that interfere with bone mineral metabolisms were excluded. One hundred accepted and consented to participation in the study. All the participants were subjected to full history taking, clinical evaluation, laboratory investigations including serum Ca, Ph, PTH, ALP, TSH, F T4, F T3, Cortisol level, and 25(OH)D level. Plain X-ray was done for the regions of bony tenderness. The subjects were divided into 2 groups based on the presence or absence of pseudo-fractures (looser zones). They were treated and followed up till normalization of the laboratory parameters and healing of the looser zones. Results: The mean age for patients was 30.45 ± 5.8, their mean 25(OH) vitamin D level was 14.7 ± 5.9 ng/ml, the mean PTH was 195.7 ± 162.6, and looser zones were evident in the X-rays of 34 patients. The serum 25(OH)D showed significant negative correlations with veiling, parity, localized hip pain, and tenderness, ALP, PTH, but, a significant positive correlation with sun exposure, dairy products consumption, vitamin D supplementation, and serum calcium levels. The independent factors associated with hypovitaminosis D were the lack of sun exposure, lack of vitamin D supplementation, and the presence of pseudo- fracture (p ≤ 0.009, 0.038, and 0.001 respectively). No surgery was required in any of our patients. Conclusions: Vitamin D deficiency is common in our region. The main risk factors are decreased sun exposure, low dairy products consumption, and lack of vitamin D supplementation. Successful medical treatment may be helpful to satisfy the patient, avoid true fracture and further major surgical treatments.