Objective: To assess cadmium sulfate(CdSO_4) and zinc chloride(ZnCl_2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats.Methods: The study included 40 adult male rats, divide...Objective: To assess cadmium sulfate(CdSO_4) and zinc chloride(ZnCl_2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats.Methods: The study included 40 adult male rats, divided into four groups: Group 1(CdSO_4), Group 2(ZnCl_2), Group 3(CdSO_4-ZnCl_2) and Group 4(control). Animals were treated withCdSO_4 and ZnCl_2 at the same dose(15 mg/L) during 30 days.Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/m L] in animals treated withCdSO_4.CdSO_4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl_2 were not recorded in this study.Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland.展开更多
文摘Objective: To assess cadmium sulfate(CdSO_4) and zinc chloride(ZnCl_2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats.Methods: The study included 40 adult male rats, divided into four groups: Group 1(CdSO_4), Group 2(ZnCl_2), Group 3(CdSO_4-ZnCl_2) and Group 4(control). Animals were treated withCdSO_4 and ZnCl_2 at the same dose(15 mg/L) during 30 days.Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/m L] in animals treated withCdSO_4.CdSO_4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl_2 were not recorded in this study.Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland.
