Nanotechnology-based gene therapy as a credible tool in the treatment of Alzheimer’s disease

Toxic aggregated amyloid-βaccumulation is a key pathogenic event in Alzheimer’s disease.Treatment approaches have focused on the suppression,deferral,or dispersion of amyloid-βfibers and plaques.Gene therapy has evolved as a potential therapeutic option for treating Alzheimer’s disease,owing to its rapid advancement over the recent decade.Small interfering ribonucleic acid has recently garnered considerable attention in gene therapy owing to its ability to down-regulate genes with high sequence specificity and an almost limitless number of therapeutic targets,including those that were once considered undruggable.However,lackluster cellular uptake and the destabilization of small interfering ribonucleic acid in its biological environment restrict its therapeutic application,necessitating the development of a vector that can safeguard the genetic material from early destruction within the bloodstream while effectively delivering therapeutic genes across the bloodbrain barrier.Nanotechnology has emerged as a possible solution,and several delivery systems utilizing nanoparticles have been shown to bypass key challenges regarding small interfering ribonucleic acid delivery.By reducing the enzymatic breakdown of genetic components,nanomaterials as gene carriers have considerably enhanced the efficiency of gene therapy.Liposomes,polymeric nanoparticles,magnetic nanoparticles,dendrimers,and micelles are examples of nanocarriers that have been designed,and each has its own set of features.Furthermore,recent advances in the specific delivery of neurotrophic compounds via gene therapy have provided promising results in relation to augmenting cognitive abilities.In this paper,we highlight the use of different nanocarriers in targeted gene delivery and small interfering ribonucleic acid-mediated gene silencing as a potential platform for treating Alzheimer’s disease.

Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer

Breast cancer is one of the leading causes of cancer-related deaths in women worldwide.It is a cancer that originates from the mammary ducts and involves mutations in multiple genes.Recently,the treatment of breast cancer has become increasingly challenging owing to the increase in tumor heterogeneity and aggressiveness,which gives rise to therapeutic resistance.Epidemiological,populationbased,and hospital-based case-control studies have demonstrated an association between high intake of certain Allium vegetables and a reduced risk in the development of breast cancer.Diallyl disulfide(DADS)and diallyl trisulfide(DATS)are the main allyl sulfur compounds present in garlic,and are known to exhibit anticancer activity as they interfere with breast cancer cell proliferation,tumor metastasis,and angiogenesis.The present review highlights multidrug resistance mechanisms and their signaling pathways in breast cancer.This review discusses the potential anticancer activities of DADS and DATS,with emphasis on drug resistance in triple-negative breast cancer(TNBC).Understanding the anticancer activities of DADS and DATS provides insights into their potential in targeting drug resistance mechanisms of TNBC,especially in clinical studies.

Nanotechnology-Based Advancements in Postharvest Management of Horticultural Crops

Horticulture is a branch of Agricultural science where it is defined as the science and art of cultivating and handling fruits,vegetables,ornamental plants and several plants having unique medicinal and aromatic values.Horticultural crops provide farmers with high income and have good export quality,but they have a concern about postharvest losses.Hence,increasing productivity and decreasing post-harvest losses by using scientific studies and techniques like biotechnology and nanotechnology could be the simplest possible solution to the above-mentioned problems.Using nanotechnology which is having the characteristics of nanoparticles is proven to be very useful in science and technological applications.Nanotechnology-based formulations increase the product quality and the shelf life of horticultural products and provide multiple ways of inhibiting the growth and development of microorganisms.It is precisely a new edible packaging coverage(film)that controls the exchange of gases and prevents damage from harmful rays such as ultraviolet radiation to a greater extent.Increasing strength by using nano biosensors for labeling products is considered a fundamental process to automated control of storage products.Postharvest rotting of vegetables is recognized to be an oxidative reaction and microbial deterioration as well.This review will address all such nanotechnology-based advancements for minimizing post-harvest losses of horticultural crops and enhancing the socio-economical progress of growers in particular.