Improving the strength of bone cement is one of the critical goals in cement designing to maintain their integrity and stabilize connection between the cement and their surrounding tissue during the time that the ceme...Improving the strength of bone cement is one of the critical goals in cement designing to maintain their integrity and stabilize connection between the cement and their surrounding tissue during the time that the cement has been replaced by matured bone tissue.To this aim,the authors decided to evaluate setting behavior and compressive strength of Magnesium Phosphate Cement(MPC)by adding carboxylated Single-Walled Carbon Nanotubes(c-SWCNTs)and assess the biocompatibility of the composite cement.MPC containing 0 wt%to 0.5 wt% of c-SWCNTs at the Powder to Liquid Ratio(PLR)of 1 g·mL^-1 to 2 g·mL^-1 were produced.Adding c-SWCNTs to MPC postponed the setting time of the cement at the beginning of the cementation process and preserved the reaction with a high rate for a longer time.In addition,the compressive strength of MPC was enhanced to 28 MPa by adding 0.2 wt%c-SWCNTs because of producing cement with compact and uniform microstructure.In addition,cell behavior on MPC with/without c-SWCNTs indicated no cytotoxic effect alongside a suitable adhesion and proliferation of them.展开更多
Mimicking compositional and constructional features of the extracellular matrix(ECM)is an effective parameter in improving the biological response of biomaterials.In this regard,carbon nanotube(CNT)and gelatin were ad...Mimicking compositional and constructional features of the extracellular matrix(ECM)is an effective parameter in improving the biological response of biomaterials.In this regard,carbon nanotube(CNT)and gelatin were added to magnesium-calcium phosphate cement(CNG)to mimic fibrillar construction and organic composition of ECM,respectively,besides the CNG performance was compared with the plain and CNT-reinforced cement.Cementation behavior of the cements was investigated by evaluating their setting time,cement composition variation during setting,and viscosity fluctuation.Furthermore,compressive strength,degradation,and cell response of the cements were compared.Adding 5 wt.%gelatin reduced setting time about 60%,because of gel formation,not due to struvite precipitation.Moreover,the gelatin decreased compressive strength by about 20%.Although gelatin decreased compressive strength,the strength remained in the range attributed to trabecular bone.All the types of cement indicated shear thinning behavior that made their injectability feasible.Compared to other types of cement,CNG enhanced proliferation and differentiation of mesenchymal stem cells besides faster degradation,nontoxicity and suitable cell adhesion.Hence,mimicking features of CNG enhanced osteoconductivity and osteoinductivity of the cement compared to the plain one.展开更多
文摘Improving the strength of bone cement is one of the critical goals in cement designing to maintain their integrity and stabilize connection between the cement and their surrounding tissue during the time that the cement has been replaced by matured bone tissue.To this aim,the authors decided to evaluate setting behavior and compressive strength of Magnesium Phosphate Cement(MPC)by adding carboxylated Single-Walled Carbon Nanotubes(c-SWCNTs)and assess the biocompatibility of the composite cement.MPC containing 0 wt%to 0.5 wt% of c-SWCNTs at the Powder to Liquid Ratio(PLR)of 1 g·mL^-1 to 2 g·mL^-1 were produced.Adding c-SWCNTs to MPC postponed the setting time of the cement at the beginning of the cementation process and preserved the reaction with a high rate for a longer time.In addition,the compressive strength of MPC was enhanced to 28 MPa by adding 0.2 wt%c-SWCNTs because of producing cement with compact and uniform microstructure.In addition,cell behavior on MPC with/without c-SWCNTs indicated no cytotoxic effect alongside a suitable adhesion and proliferation of them.
文摘Mimicking compositional and constructional features of the extracellular matrix(ECM)is an effective parameter in improving the biological response of biomaterials.In this regard,carbon nanotube(CNT)and gelatin were added to magnesium-calcium phosphate cement(CNG)to mimic fibrillar construction and organic composition of ECM,respectively,besides the CNG performance was compared with the plain and CNT-reinforced cement.Cementation behavior of the cements was investigated by evaluating their setting time,cement composition variation during setting,and viscosity fluctuation.Furthermore,compressive strength,degradation,and cell response of the cements were compared.Adding 5 wt.%gelatin reduced setting time about 60%,because of gel formation,not due to struvite precipitation.Moreover,the gelatin decreased compressive strength by about 20%.Although gelatin decreased compressive strength,the strength remained in the range attributed to trabecular bone.All the types of cement indicated shear thinning behavior that made their injectability feasible.Compared to other types of cement,CNG enhanced proliferation and differentiation of mesenchymal stem cells besides faster degradation,nontoxicity and suitable cell adhesion.Hence,mimicking features of CNG enhanced osteoconductivity and osteoinductivity of the cement compared to the plain one.
