Demographic, Clinical and Biochemical Characteristics of Drug Naive Type 2 Diabetes Patients of Bangladesh

Background: Although the frequencies of getting drug naive type 2 diabetes patients among all the diabetic patients are very low, nowadays it claims more attention in the treatment procedures of drug naive diabetic patients. But in Bangladesh, we have very few research-oriented data regarding the demographic, clinical and biochemical characteristics of drug naive type 2 diabetes patients. The aim of this study was to determine the demographic clinical and biochemical characteristics of drug naive type 2 diabetes patients of Bangladesh. Methods: This was an open label observational real-life study which was conducted in the chambers of the investigators in several places of Bangladesh as outdoor setting during the period from August 2020 to December 2020. In total, 250 patients with drug naive type 2 diabetes mellitus were enrolled as the study population. Proper written consents were taken from all the participants before starting data collection. A pre-designed questionnaire was used in patient data collection. All data were processed, analyzed and disseminated by MS Office and SPSS version as per need. Result: Two hundred and fifty (250) participants were selected as study population. The male-female ratio of the participants was 1.4:1. The highest number of participants was from 51 - 60 years’ age group (31.20%). The highest number of participants (41%) was with overweight (BMI: 25 - 30 kg/m2). Majority (65%) of the patients of this study suffered from diabetes for ≤5 years. The mean (±SD) SBP of the participants was 137.25 ± 17.50 mmHg and the mean (±SD) DBP of the participants was 85.16 ± 13.39 mmHg. We found the mean (±SD) fasting blood sugar (mg/dl), post prandial blood sugar (mg/dl), total cholesterol (mg/dl), triglycerides (mg/dl), HDL-Cholesterol (mg/dl), LDL-cholesterol (mg/dl), VLDL-cholesterol (mg/dl), uric acid (mg/dl), creatinine (mg/dl), urea (mg/dl), total bilirubin (mg/dl), direct bilirubin (mg/dl), SGOT (IU/L) and SGPT (IU/L) were 251.51 ± 112.08, 349.72 ± 128.68, 219.59 ± 68.25, 196.44 ± 94.34, 35.14 ± 11.85, 145.72 ± 64.33, 40.88 ± 18.12, 3.45 ± 1.51, 0.86 ± 0.37, 29.16 ± 9.81, 0.87 ± 0.4, 0.48 ± 0.4, 37.15 ± 10.9 and 35.83 ± 23.04 respectively. Conclusion: Obesity and hypertension demand more attention of diabetologists in diagnosis and treatment of patients or suspected patients of diabetes. Patients aged ≥ 50 years are most vulnerable and suspicious for diabetes. Besides age consequence habits of tobacco smoking, family history, smoking and HTN, alcohol intake and presence of nitrites in the urine may be considered as the most potential comorbidities for diabetic patients. Diagnosis of demographic, clinical and biochemical characteristics of drug naive type 2 diabetes patients may play a vital role in proper treatment.

Growth Performance, Feed Conversion Ratio and Economics of Production of Native and Crossbred （Local x Holstein Friesian） Bulls for Fattening under Different Improved Feeding

An experiment was conducted to evaluate the growth performance and cost per gain of indigenous and crossbred （local x Holstein Friesian （L x HF）） bulls under four different improved feed treatments to determine the appropriate ration for economic organic beef production in Bangladesh. Twenty indigenous bulls （average body weight 208.08 ± 13.98 kg） and 20 crossbred （L x l-IF） bulls （average body weight 256.26 ± 26.85 kg） of 24 months age were divided into four equal groups and fed on four diets （T0, T1, T2 and T3） up to 120 d, where To referred to the conventional diet, and T1, T2 and T3 referred as improved organic diets. Required dry matter for individual animal was supplied by roughage and concentrate sources of the ration in the ratio of 2：1. Local grass and paddy straw were supplied to group T0 and T1, Napier grass and straw to group T2, and Napier grass （Pennisetum purpureum）, straw and Ipil-ipil leaf （Leuceana leucucephala） to group Ts as roughage; whereas, the concentrate was supplied as 1.5% of live weight. The results revealed that total dry matter intake （DMI）, total DMI as percent live weight （%LW）, feed conversion ratio （FCR） and average daily gain （ADG） varied significantly （P 〈 0.01） among different treatment groups. Breed also had significant （P 〈 0.01） effect on total DMI, FCR and ADG, but total DMI （%LW） was not affected by breed type. Feed cost expressed as per kg live weight gain （LWG） （BDT/kg LWG; 1USD = 78.95 BDT）, were also affected （P 〈 0.01） by feed treatments and breed type. Indigenous and crossbred bulls fed diet T3 had higher ADG （0.49 kg and 1.17 kg, respectively） and comparatively lower feed costs （156 BDT/kg LWG and 96.78 BDT/kg LWG, respectively）. But crossbred （L × HF） bulls showed the highest ADG （1.17 kg） and the lowest feed cost （96.78 BDT/kg LWG）. Therefore, considering the growth performance and cost per kg gain of the experimental animals, it may be concluded that the crossbred （Lx HF） bulls treated with T3 diet may be used for economic organic beef production in Bangladesh.

Autophagy as a targeted therapeutic approach for skin cancer:Evaluating natural and synthetic molecular interventions

Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing incidence.Autophagy,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental effects.This duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic potential.This systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin cancer.We outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin cancer.This comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin cancer.Each of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in detail.Interestingly,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal models.Consequently,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.