Image quality in positron emission tomography(PET)is affected by random and scattered coincidences and reconstruction protocols.In this study,we investigated the effects of scattered and random coincidences from outsi...Image quality in positron emission tomography(PET)is affected by random and scattered coincidences and reconstruction protocols.In this study,we investigated the effects of scattered and random coincidences from outside the field of view(FOV)on PET image quality for different reconstruction protocols.Imaging was performed on the Discovery 690 PET/CT scanner,using experimental configurations including the NEMA phantom(a body phantom,with six spheres of different sizes)with a signal background ratio of 4:1.The NEMA phantom(phantom I)was scanned separately in a one-bed position.To simulate the effect of random and scatter coincidences from outside the FOV,six cylindrical phantoms with various diameters were added to the NEMA phantom(phantom II).The 18 emission datasets with mean intervals of 15 min were acquired(3 min/scan).The emission data were reconstructed using different techniques.The image quality parameters were evaluated by both phantoms.Variations in the signal-to-noise ratio(SNR)in a 28-mm(10-mm)sphere of phantom II were 37.9%(86.5%)for ordered-subset expectation maximization(OSEM-only),36.8%(81.5%)for point spread function(PSF),32.7%(80.7%)for time of flight(TOF),and 31.5%(77.8%)for OSEM+PSF+TOF,respectively,indicating that OSEM+PSF+TOF reconstruction had the lowest noise levels and lowest coefficient of variation(COV)values.Random and scatter coincidences from outside the FOV induced lower SNR,lower contrast,and higher COV values,indicating image deterioration and significantly impacting smaller sphere sizes.Amongst reconstruction protocols,OSEM+PSF+TOF and OSEM+PSF showed higher contrast values for sphere sizes of 22,28,and 37 mm and higher contrast recovery coefficient values for smaller sphere sizes of 10 and 13 mm.展开更多
It is well known that inter-crystal scattering and penetration(ICS-P) are major spatial resolution limiting parameters in dedicated SPECT scanners with pixelated crystal.In this study,the effect of ICS-P on crystal id...It is well known that inter-crystal scattering and penetration(ICS-P) are major spatial resolution limiting parameters in dedicated SPECT scanners with pixelated crystal.In this study,the effect of ICS-P on crystal identification in different crystal configurations was evaluated using GATE Monte Carlo simulation.A ^(99m)Tc pencil-beam toward central crystal element was utilized.Beam incident angle was assumed to vary from 0° to 45° in 5° steps.The effects of various crystal configurations such as pixel-size,pixel-gap,and crystal material were studied.The influence of photon energy on the crystal identification(CI) was also investigated.Position detection accuracy(PDA) was defined as a factor indicating performance of the crystal.Furthermore,a set of ^(99m)Tc point-source simulations was performed in order to calculate peak-to-valley(PVR) ratio for each configuration.The results show that the CsI(Na)manifests higher PDA than NaI(TI) and YAP(Ce).In addition,as the incident angle increases,the crystal becomes less accurate in positioning of the events.Beyond a crystal-dependent critical angle,the PDA monotonically reduces.The PDA reaches 0.44 for the CsI(Na) at 45° beam angle.The PDAs obtained by the point-source evaluation also behave the same as for the pencil-beam irradiations.In addition,the PVRs derived from flood images linearly correlate their corresponding PDAs.In conclusion,quantitative assessment of ICS-P is mandatory for scanner design and modeling the system matrix during iterative reconstruction algorithms for the purpose of resolution modeling in ultra-high-resolution SPECT.展开更多
基金supported by the Tehran University of Medical Sciences under Grant No.36291PET/CT and Cyclotron Center of Masih Daneshvari Hospital at Shahid Beheshti University of Medical Sciences。
文摘Image quality in positron emission tomography(PET)is affected by random and scattered coincidences and reconstruction protocols.In this study,we investigated the effects of scattered and random coincidences from outside the field of view(FOV)on PET image quality for different reconstruction protocols.Imaging was performed on the Discovery 690 PET/CT scanner,using experimental configurations including the NEMA phantom(a body phantom,with six spheres of different sizes)with a signal background ratio of 4:1.The NEMA phantom(phantom I)was scanned separately in a one-bed position.To simulate the effect of random and scatter coincidences from outside the FOV,six cylindrical phantoms with various diameters were added to the NEMA phantom(phantom II).The 18 emission datasets with mean intervals of 15 min were acquired(3 min/scan).The emission data were reconstructed using different techniques.The image quality parameters were evaluated by both phantoms.Variations in the signal-to-noise ratio(SNR)in a 28-mm(10-mm)sphere of phantom II were 37.9%(86.5%)for ordered-subset expectation maximization(OSEM-only),36.8%(81.5%)for point spread function(PSF),32.7%(80.7%)for time of flight(TOF),and 31.5%(77.8%)for OSEM+PSF+TOF,respectively,indicating that OSEM+PSF+TOF reconstruction had the lowest noise levels and lowest coefficient of variation(COV)values.Random and scatter coincidences from outside the FOV induced lower SNR,lower contrast,and higher COV values,indicating image deterioration and significantly impacting smaller sphere sizes.Amongst reconstruction protocols,OSEM+PSF+TOF and OSEM+PSF showed higher contrast values for sphere sizes of 22,28,and 37 mm and higher contrast recovery coefficient values for smaller sphere sizes of 10 and 13 mm.
基金supported by Research Center for Molecular and Cellular Imaging(RCMCI),Tehran University of Medical Sciences(No.29885)
文摘It is well known that inter-crystal scattering and penetration(ICS-P) are major spatial resolution limiting parameters in dedicated SPECT scanners with pixelated crystal.In this study,the effect of ICS-P on crystal identification in different crystal configurations was evaluated using GATE Monte Carlo simulation.A ^(99m)Tc pencil-beam toward central crystal element was utilized.Beam incident angle was assumed to vary from 0° to 45° in 5° steps.The effects of various crystal configurations such as pixel-size,pixel-gap,and crystal material were studied.The influence of photon energy on the crystal identification(CI) was also investigated.Position detection accuracy(PDA) was defined as a factor indicating performance of the crystal.Furthermore,a set of ^(99m)Tc point-source simulations was performed in order to calculate peak-to-valley(PVR) ratio for each configuration.The results show that the CsI(Na)manifests higher PDA than NaI(TI) and YAP(Ce).In addition,as the incident angle increases,the crystal becomes less accurate in positioning of the events.Beyond a crystal-dependent critical angle,the PDA monotonically reduces.The PDA reaches 0.44 for the CsI(Na) at 45° beam angle.The PDAs obtained by the point-source evaluation also behave the same as for the pencil-beam irradiations.In addition,the PVRs derived from flood images linearly correlate their corresponding PDAs.In conclusion,quantitative assessment of ICS-P is mandatory for scanner design and modeling the system matrix during iterative reconstruction algorithms for the purpose of resolution modeling in ultra-high-resolution SPECT.