Gly-LysPred: Identification of Lysine Glycation Sites in Protein Using Position Relative Features and Statistical Moments via Chou’s 5 Step Rule

Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a peptide.It is a clinically important attribute to numerous age-related,metabolic,and chronic diseases such as diabetes,Alzheimer’s,renal failure,etc.Identification of a non-enzymatic reaction are quite challenging in research.Manual identification in labs is a very costly and timeconsuming process.In this research,we developed an accurate,valid,and a robust model named as Gly-LysPred to differentiate the glycated sites from non-glycated sites.Comprehensive techniques using position relative features are used for feature extraction.An algorithm named as a random forest with some preprocessing techniques and feature engineering techniques was developed to train a computational model.Various types of testing techniques such as self-consistency testing,jackknife testing,and cross-validation testing are used to evaluate the model.The overall model’s accuracy was accomplished through self-consistency,jackknife,and cross-validation testing 100%,99.92%,and 99.88%with MCC 1.00,0.99,and 0.997 respectively.In this regard,a user-friendly webserver is also urbanized to accumulate the whole procedure.These features vectorization methods suggest that they can play a critical role in other web servers which are developed to classify lysine glycation.

Automatic Data Clustering Based Mean Best Artificial Bee Colony Algorithm

Fuzzy C-means(FCM)is a clustering method that falls under unsupervised machine learning.The main issues plaguing this clustering algorithm are the number of the unknown clusters within a particular dataset and initialization sensitivity of cluster centres.Artificial Bee Colony(ABC)is a type of swarm algorithm that strives to improve the members’solution quality as an iterative process with the utilization of particular kinds of randomness.However,ABC has some weaknesses,such as balancing exploration and exploitation.To improve the exploration process within the ABC algorithm,the mean artificial bee colony(MeanABC)by its modified search equation that depends on solutions of mean previous and global best is used.Furthermore,to solve the main issues of FCM,Automatic clustering algorithm was proposed based on the mean artificial bee colony called(AC-MeanABC).It uses the MeanABC capability of balancing between exploration and exploitation and its capacity to explore the positive and negative directions in search space to find the best value of clusters number and centroids value.A few benchmark datasets and a set of natural images were used to evaluate the effectiveness of AC-MeanABC.The experimental findings are encouraging and indicate considerable improvements compared to other state-of-the-art approaches in the same domain.