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Chenopodium ambrosioides induces an endothelium-dependent relaxation of rat isolated aorta
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作者 Asmae Assaidi Ikram Dib +9 位作者 Monique Tits Luc Angenot Said Bellahcen Nourelhouda Bouanani Abdelkhaleq Legssyer mohammed Aziz Hassane Mekhfi mohammed bnouham Michel Frederich Abderrahim Ziyyat 《Journal of Integrative Medicine》 SCIE CAS CSCD 2019年第2期115-124,共10页
Objective: This study aims to evaluate the vasodilatory effect of Chenopodium ambrosioides on the isolated rat aorta, and to explore its mechanism of action.Methods: The vasorelaxant effect and the mode of action of v... Objective: This study aims to evaluate the vasodilatory effect of Chenopodium ambrosioides on the isolated rat aorta, and to explore its mechanism of action.Methods: The vasorelaxant effect and the mode of action of various extracts from the leaves of C. ambrosioides were evaluated on thoracic aortic rings isolated from Wistar rats. In addition, ethyl acetate and methanol fractions were analyzed, using thin-layer chromatography and high-performance liquid chromatography techniques, for their polyphenolic content.Results: The various active extracts of C. ambrosioides at four concentrations(10^(-3), 10^(-2), 10^(-1) and 1 mg/mL) relaxed the contraction elicited by phenylephrine, in a concentration-dependent manner.This effect seems to be endothelium-dependent, since the vasodilatory effect was entirely absent in denuded aortic rings. The vasorelaxant effect of the methanol fraction(MF) of C. ambrosioides at 1 mg/mL was also inhibited by atropine and tetraethylammonium. This effect remained unchanged by Nx-nitro-L-arginine methyl ester hydrochloride and glibenclamide. The preliminary phytochemical analysis showed that the leaves of C. ambrosioides are rich in phenolic and flavonoid derivatives.Conclusion: These results suggest that the MF of C. ambrosioides produces an endothelium-dependent relaxation of the isolated rat aorta, which is thought to be mediated mainly through stimulation of the muscarinic receptors, and probably involving the opening of Ca^(2+)-activated potassium channels. 展开更多
关键词 CHENOPODIUM ambrosioides CHENOPODIACEAE VASORELAXATION Ca^2+-activated potassium channels THIN-LAYER CHROMATOGRAPHY High-performance liquid CHROMATOGRAPHY Plant Complementary and alternative medicine
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