Objective:To determine the antimoraxella activity of Ethiopian medicinal plants extracts. Methods:Two clinical isolates of Moraxella cattarhalis(M.cattarhalis) with different antibiotic sensitivity pattern were tested...Objective:To determine the antimoraxella activity of Ethiopian medicinal plants extracts. Methods:Two clinical isolates of Moraxella cattarhalis(M.cattarhalis) with different antibiotic sensitivity pattern were tested to determine their susceptibility to garlic[Allium sativum(A. sativum)],bark of cinnamon[Cinnamomum zeylanicum(C.zeylanicum)],clove[Syzygium aromaticum(S.aromaticum)],and leaves of avocado[Persea americana(P.americana)], rosemary[Rosmarinus of ficinalis(R.of ficinalis)]and prickly poppy[Argemone mexicana(A. mexicana)].Disk diffusion assay and broth dilution method were used to measure zone of inhibition,minimum inhibitory concentration(MIC) and minimum bactericidal concentration (MBC) of plant extracts against M.cattarhalis.Results:Both the strains of M.cattarhalis exhibited similar sensitivities to the extracts of medicinal plants.Antimoraxella activity was exhibited only by garlic,avocado leaves and cinnamon.Garlic was found to be more antagonistic to M.cattarhalis than cinnamon and avocado.Garlic and avocado leaves have shown similar MIC(30 mg/mL) where as their zone of inhibition(15 and 11 mm,respectively) were different. Conclusions:Garlic,cinnamon and avocado leaves extracts represents alternative source of natural antimicrobial substances for use in clinical practice for the treatment of cases of M. cattarhalis.Further research on the effects of these extracts on M.cattarhalis can be rewarding to pursue in the search for new broad spectrum antimicrobial agents.展开更多
文摘Objective:To determine the antimoraxella activity of Ethiopian medicinal plants extracts. Methods:Two clinical isolates of Moraxella cattarhalis(M.cattarhalis) with different antibiotic sensitivity pattern were tested to determine their susceptibility to garlic[Allium sativum(A. sativum)],bark of cinnamon[Cinnamomum zeylanicum(C.zeylanicum)],clove[Syzygium aromaticum(S.aromaticum)],and leaves of avocado[Persea americana(P.americana)], rosemary[Rosmarinus of ficinalis(R.of ficinalis)]and prickly poppy[Argemone mexicana(A. mexicana)].Disk diffusion assay and broth dilution method were used to measure zone of inhibition,minimum inhibitory concentration(MIC) and minimum bactericidal concentration (MBC) of plant extracts against M.cattarhalis.Results:Both the strains of M.cattarhalis exhibited similar sensitivities to the extracts of medicinal plants.Antimoraxella activity was exhibited only by garlic,avocado leaves and cinnamon.Garlic was found to be more antagonistic to M.cattarhalis than cinnamon and avocado.Garlic and avocado leaves have shown similar MIC(30 mg/mL) where as their zone of inhibition(15 and 11 mm,respectively) were different. Conclusions:Garlic,cinnamon and avocado leaves extracts represents alternative source of natural antimicrobial substances for use in clinical practice for the treatment of cases of M. cattarhalis.Further research on the effects of these extracts on M.cattarhalis can be rewarding to pursue in the search for new broad spectrum antimicrobial agents.
