Aberrant expression of lysosomal cysteine proteinases（cathepsins）leads to abnormal proteolytic processing of extracellular matrix proteins.This in turn promotes invasion,migration and metastasis of tumor cells（Nomu...Aberrant expression of lysosomal cysteine proteinases（cathepsins）leads to abnormal proteolytic processing of extracellular matrix proteins.This in turn promotes invasion,migration and metastasis of tumor cells（Nomura and Katunuma,2005）.Cystatins are natural inhibitors of cathepsins.Therefore,dysregulated expression of cystatins and the consequent alteration in the cathepsin：cystatin ratio are likely to play an important role in malignant progression of tumors.展开更多
基金supported by the grant from the Department of Biotechnology,Govt.of India(Sanction order No.6242-P90/RGCB/PMD/DBT/ANLM,to A.M.L.)
文摘Aberrant expression of lysosomal cysteine proteinases（cathepsins）leads to abnormal proteolytic processing of extracellular matrix proteins.This in turn promotes invasion,migration and metastasis of tumor cells（Nomura and Katunuma,2005）.Cystatins are natural inhibitors of cathepsins.Therefore,dysregulated expression of cystatins and the consequent alteration in the cathepsin：cystatin ratio are likely to play an important role in malignant progression of tumors.
