Dendritic cells(DCs)are the master regulators of the immune response and engage in constant cross-talk with other immune cells to initiate an appropriate immune response.The outcome of cross-talk with various immune c...Dendritic cells(DCs)are the master regulators of the immune response and engage in constant cross-talk with other immune cells to initiate an appropriate immune response.The outcome of cross-talk with various immune cells towards DC functions has been shown to be dependent on the particular subset of cells and their activation stimuli.Here we show that for human B cells to induce maturation of DCs with an enhanced T-cell stimulatory capacity,B-cell receptor(BCR)signaling is sufficient for memory B-cells,whereas additional CD40 signaling is required for naïve B cells to induce complete activation of DCs.展开更多
基金Supported by the Institut National de la Santé et de la Recherche Médicale (INSERM),Sorbonne Université and Université Paris Descartes, Paris, France.
文摘Dendritic cells(DCs)are the master regulators of the immune response and engage in constant cross-talk with other immune cells to initiate an appropriate immune response.The outcome of cross-talk with various immune cells towards DC functions has been shown to be dependent on the particular subset of cells and their activation stimuli.Here we show that for human B cells to induce maturation of DCs with an enhanced T-cell stimulatory capacity,B-cell receptor(BCR)signaling is sufficient for memory B-cells,whereas additional CD40 signaling is required for naïve B cells to induce complete activation of DCs.
