AIM: To compare the response of standard hepatitis B virus (HBV) vaccination between patients with chronic hepatitis C virus (HCV) infection and healthy individuals. METHODS: This is a prospective case-control study. ...AIM: To compare the response of standard hepatitis B virus (HBV) vaccination between patients with chronic hepatitis C virus (HCV) infection and healthy individuals. METHODS: This is a prospective case-control study. A total of 38 patients with chronic HCV infection and 40 healthy controls were included. Vaccination was performed by injection of 20 μg recombinant HBsAg into the deltoid muscle at mo 0, 1 and 6. Anti-HBs concentration was determined 3 mo after the last dose and compared between the two groups. The response pattern was characterized as (1) high-response when the anti-HBs antibody titer was > 100 IU/L, (2) low-response when the titer was 10-100 IU/L and (3) no-response when the titer was < 10 IU/L. RESULTS: In the patient group, there were 10/38 (26.3%) non-responders, 8/38 (21.1%) low-responders and 20/38 (52.6%) high-responders. The corresponding values in the control group were 2/40 (5.0%), 7/40 (17.5%) and 31/40 (77.5%), respectively. The response pattern was statistically different between the two groups. In multivariate analysis, smoking was a significant confounder, while HCV infection lost its significant correlation with lower antibody response. CONCLUSION: Patients with chronic HCV infection tend to respond weakly to HBV vaccination compared to healthy individuals, though this correlation is not independent according to multivariate analysis.展开更多
Terminalia chebula(family:Combretaceae)is widely used in the traditional medicine of India and Iran to treat diseases that include dementia,constipation,and diabetes.This tree is known in Iranian traditional medicine(...Terminalia chebula(family:Combretaceae)is widely used in the traditional medicine of India and Iran to treat diseases that include dementia,constipation,and diabetes.This tree is known in Iranian traditional medicine(ITM)as halileh or halilaj and the fruit is used to develop treatments.It is described in ITM as an astringent that has a"cold"and"dry"temperament.References to the medicinal properties of Terminalia chebula were collected from important ITM sources and from modern medical databases(Pub Med,Scirus,Science Direct,and Scopus).The medicinal properties described for thistree in ITM were compared with those reported in studies of modern phytotherapy.The results confirm that the tree referred to as halileh in traditional books is the Terminalia chebula used in present-day studies.Treatments that have not been evaluated in modern phytotherapy but have been traditionally treated with Terminalia chebula include fever,and psychological and psychiatric issues.This article confirms the medicinal uses of Terminalia chebula.展开更多
文摘AIM: To compare the response of standard hepatitis B virus (HBV) vaccination between patients with chronic hepatitis C virus (HCV) infection and healthy individuals. METHODS: This is a prospective case-control study. A total of 38 patients with chronic HCV infection and 40 healthy controls were included. Vaccination was performed by injection of 20 μg recombinant HBsAg into the deltoid muscle at mo 0, 1 and 6. Anti-HBs concentration was determined 3 mo after the last dose and compared between the two groups. The response pattern was characterized as (1) high-response when the anti-HBs antibody titer was > 100 IU/L, (2) low-response when the titer was 10-100 IU/L and (3) no-response when the titer was < 10 IU/L. RESULTS: In the patient group, there were 10/38 (26.3%) non-responders, 8/38 (21.1%) low-responders and 20/38 (52.6%) high-responders. The corresponding values in the control group were 2/40 (5.0%), 7/40 (17.5%) and 31/40 (77.5%), respectively. The response pattern was statistically different between the two groups. In multivariate analysis, smoking was a significant confounder, while HCV infection lost its significant correlation with lower antibody response. CONCLUSION: Patients with chronic HCV infection tend to respond weakly to HBV vaccination compared to healthy individuals, though this correlation is not independent according to multivariate analysis.
文摘Terminalia chebula(family:Combretaceae)is widely used in the traditional medicine of India and Iran to treat diseases that include dementia,constipation,and diabetes.This tree is known in Iranian traditional medicine(ITM)as halileh or halilaj and the fruit is used to develop treatments.It is described in ITM as an astringent that has a"cold"and"dry"temperament.References to the medicinal properties of Terminalia chebula were collected from important ITM sources and from modern medical databases(Pub Med,Scirus,Science Direct,and Scopus).The medicinal properties described for thistree in ITM were compared with those reported in studies of modern phytotherapy.The results confirm that the tree referred to as halileh in traditional books is the Terminalia chebula used in present-day studies.Treatments that have not been evaluated in modern phytotherapy but have been traditionally treated with Terminalia chebula include fever,and psychological and psychiatric issues.This article confirms the medicinal uses of Terminalia chebula.
