TIRAP rs8177374 gene polymorphism increased the risk of pulmonary tuberculosis in Zahedan,southeast Iran

Objective:To evaluate the possible association between Toll-interleukin 1 receptor(TIR) domain containing adaptor protein(TIRAP;also known as MAI.) rsl893352 and rs8l77374(S180L) gene polymorphisms and pulmonary tuberculosis(PTB) in a sample of Iranian population.Methods:This case-control study was performed on 174 PTB and 177 healthy subjects.Tetra amplification refractory mutation systetn-polymerase chain reaction(T-AKMS-PCR) was used to detect the polymorphisms.Results:Our finding showed that neither the overall Ckisqaare comparison of PTB and control subjects nor the logistic regression analysis indicated any association between rsl893352 polymorphism and PTB.Regarding rs8l77374 polymorphism,the CT genotype as well as CT+TT increased the risk of PTB in comparison with CC genotype(OR=4.73,95%CI=2.65-8.45,P<0.0001 and OR=6.47,95%C1=3.68-11.38,P<0.0001.respectively).The rs8177374 T allele increased the risk of PTB in comparison with C allele(OR=4.21.95%CI=2.43-7.26,P<0.0001).Conclusions:Our finding indicates that TIRAP rs8177374 polymorphism is associated with PTB in a sample of Iranian population.

Toll-like Receptor 1 Polymorphisms Increased the Risk of Pulmonary Tuberculosis in an Iranian Population Sample

A case-control study was carried out that involved 203 individuals diagnosed with pulmonary tuberculosis （PTB） and 203 healthy subjects. Genotyping of TLR1 rs5743551 and rs5743618 polymorphisms was done using polymerase chain reaction-restriction fragments length polymorphism assay. We found that TLR1 rs5743551 variant affected the risk of PTB in the codominant （OR=3.28, 95% C1=1.98-5.45, P〈0.0001, GA vs. GG; OR=1.86, 95% C1=1.05-3.28, P=0.033, AA vs. GG） and dominant （OR=2.69, 95% C1=1.67-4.34, P〈0.0001, GA＋AA vs. GG） inheritance models tested. The A allele was associated with a higher risk of PTB than the G allele （OR=1.33, 95% C1=1.01-1.75, P=0.049）. The TG genotype of the rs5743618 variant significantly increased the risk of PTB compared to the risk associated with the TT genotype （0R=3.29, 95% C1=1.82-5.97, P〈0.0001）. The G allele was associated with a higher risk of PTB than the T allele （OR=3.00, 95% C1=1.69-5.31, P=0.0001）. Our findings revealed that TLR1 rs5743551 and rs5743618 polymorphisms affected the risk of PTB in an Iranian population sample. Additional studies with larger sample sizes and involving subjects of different ethnicities are required to validate our present findings.