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慢性炎症性脱髓鞘性多发性神经病变的长期预后:一项包括38例患者的5年随访研究
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作者 Kuwabara S. misawa S. +1 位作者 mori m. 王鹏(译) 《世界核心医学期刊文摘(神经病学分册)》 2006年第5期47-48,共2页
Background: Little is known about long term prognosis and course after immune treatments in chronic inflammatory demyelinating polyneuropathy (CIDP). Objective: To study long term outcomes and prognostic factors in pa... Background: Little is known about long term prognosis and course after immune treatments in chronic inflammatory demyelinating polyneuropathy (CIDP). Objective: To study long term outcomes and prognostic factors in patients with CIDP. Methods: Clinical and electrophysiological findings, responses to immune modulating treatments, and outcomes five years after the start of treatment were reviewed in 38 CIDP patients. Results: Patients were treated with corticosteroids (89% ), immunoglobulin infusion (45% ), or plasmapheresis (34% ), and 58% received combined therapy. Five years after treatment was begun, 10 (26% ) of the patients had complete remission (lasting >2 years with normal nerve conduction studies), and 23 (61% ) had partial remission (able to walk) with (26% ) or without (34% ) immune treatments. The remaining five patients (13% ) still had severe disability (unable to walk) or treatment dependent relapses. Patients with complete remission more often had subacute onset, symmetrical symptoms, good response to initial corticosteroid treatment, and nerve conduction abnormalities predominant in the distal nerve terminals. In contrast, insidious onset, asymmetrical symptoms, and electrophysiological evidence of demyelination in the intermediate nerve segments were associated with refractoriness to treatment or treatment dependent relapse. Conclusions: The long term prognosis of CIDP patients was generally favourable, but 39% of patients still required immune treatments and 13% had severe disabilities. Mode of onset, distribution of symptoms, and electrophysiological characteristics may be prognostic factors for predicting a favourable outcome. 展开更多
关键词 多发性神经病变 长期预后 脱髓鞘性 炎症性 患者 随访研究 慢性 皮质激素治疗 免疫治疗 治疗依赖性
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原发性皮肤B细胞淋巴瘤的局部光动力学治疗:一项先导性研究
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作者 mori m. Campolmi P. +2 位作者 mavilia L. N. Pimpinelli 党倩丽 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第5期7-7,共1页
Photodynamic therapy (PDT) is a treatment based on the accumulation of a photosensitizer in the target cells and their selective destruction by irradiation with visible light. In the past 10 years, several patients wi... Photodynamic therapy (PDT) is a treatment based on the accumulation of a photosensitizer in the target cells and their selective destruction by irradiation with visible light. In the past 10 years, several patients with cutaneous T cell lymphoma have been successfully treated. The use of PDT in cutaneous B cell lymphoma has not been reported to date. We report the successful PDT treatment of 3 patients with early primary cutaneousBcell lymphoma. 展开更多
关键词 光动力学治疗 B细胞淋巴瘤 选择性破坏 光敏剂 可见光辐射
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