Respiratory symptoms elicited by perfume are common in the population but have unclear pathophysiology. Increased capsaicin cough responsiveness has been associated with the symptoms, but it is unknown whether the sit...Respiratory symptoms elicited by perfume are common in the population but have unclear pathophysiology. Increased capsaicin cough responsiveness has been associated with the symptoms, but it is unknown whether the site of the symptoms in the airways influences this association. The aim of this study was to investigate the association between the site of airway symptoms elicited by perfume and cough responsiveness to bronchial challenge with capsaicin. 21 eczema patients with respiratory symptoms elicited by perfume were compared with 21 healthy volunteers in a sex and age-matched case control study. The participants completed a symptom questionnaire and underwent a bronchial challenge with capsaicin.Lower, but not upper, respiratory symptoms elicited by perfume were associated with increased capsaicin cough responsiveness. Having severe symptoms to perfume (n = 11) did not relate to the site of the symptoms in the airways and was not associated with increased capsaicin cough responsiveness.In conclusion, respiratory symptoms elicited by perfume may reflect local hyperreactivity related to defensive reflexes in the airways, and measurements of the capsaicin cough reflex are relevant when patients with lower respiratory symptoms related to environmental perfume exposures are investigated.展开更多
Background:Exposure to volatile fragrances is commonplace and may be related to various eye and airway symptoms. Skin exposure to fragrances is known to caus e perfume contact allergy and eczema, but it is unknown whe...Background:Exposure to volatile fragrances is commonplace and may be related to various eye and airway symptoms. Skin exposure to fragrances is known to caus e perfume contact allergy and eczema, but it is unknown whether eye or airway sy mptoms elicited by fragrance products are associated with contact allergy or ecz ema. Objectives:To investigate if eye and airway symptoms elicited by fragrance products are associated with perfume contact allergy or hand eczema in a popula tion-based sample. Methods:A questionnaire on eye and airway symptoms elicited by fragrance products was mailed to 1189 individuals who had recently participa ted in a Danish population-based study of allergic diseases. Results from the q uestionnaire about localization and character of the symptoms were compared with data on patch testing and 1-year prevalence of hand eczema collected during th e health examination. Results:Positive, independent and significant (P < 0.05) associations were found between eye and airway symptoms elicited by fragrance pr oducts and perfume contact allergy (adjusted odds ratios 2.0-3.7) and hand ecze ma (adjusted odds ratios 1.62.6). In further analysis, similar and consistent re sults were found regarding severity of the symptoms. No associations were found between nickel contact allergy and the symptoms. Female sex and psychological vu lnerability were independently associated with eye and airway symptoms elicited by fragrance products, but adjustment in multivariate analysis did not change th e results regarding perfume contact allergy and hand eczema. Conclusions:Indivi duals with perfume contact allergy and/or hand eczema, as opposed to those witho ut, have more frequent and more severe eye or airway symptoms after exposure to volatile fragrance products. Having hand eczema has the greatest impact on repor ting eye and airway symptoms elicited by fragrance products.展开更多
文摘Respiratory symptoms elicited by perfume are common in the population but have unclear pathophysiology. Increased capsaicin cough responsiveness has been associated with the symptoms, but it is unknown whether the site of the symptoms in the airways influences this association. The aim of this study was to investigate the association between the site of airway symptoms elicited by perfume and cough responsiveness to bronchial challenge with capsaicin. 21 eczema patients with respiratory symptoms elicited by perfume were compared with 21 healthy volunteers in a sex and age-matched case control study. The participants completed a symptom questionnaire and underwent a bronchial challenge with capsaicin.Lower, but not upper, respiratory symptoms elicited by perfume were associated with increased capsaicin cough responsiveness. Having severe symptoms to perfume (n = 11) did not relate to the site of the symptoms in the airways and was not associated with increased capsaicin cough responsiveness.In conclusion, respiratory symptoms elicited by perfume may reflect local hyperreactivity related to defensive reflexes in the airways, and measurements of the capsaicin cough reflex are relevant when patients with lower respiratory symptoms related to environmental perfume exposures are investigated.
文摘Background:Exposure to volatile fragrances is commonplace and may be related to various eye and airway symptoms. Skin exposure to fragrances is known to caus e perfume contact allergy and eczema, but it is unknown whether eye or airway sy mptoms elicited by fragrance products are associated with contact allergy or ecz ema. Objectives:To investigate if eye and airway symptoms elicited by fragrance products are associated with perfume contact allergy or hand eczema in a popula tion-based sample. Methods:A questionnaire on eye and airway symptoms elicited by fragrance products was mailed to 1189 individuals who had recently participa ted in a Danish population-based study of allergic diseases. Results from the q uestionnaire about localization and character of the symptoms were compared with data on patch testing and 1-year prevalence of hand eczema collected during th e health examination. Results:Positive, independent and significant (P < 0.05) associations were found between eye and airway symptoms elicited by fragrance pr oducts and perfume contact allergy (adjusted odds ratios 2.0-3.7) and hand ecze ma (adjusted odds ratios 1.62.6). In further analysis, similar and consistent re sults were found regarding severity of the symptoms. No associations were found between nickel contact allergy and the symptoms. Female sex and psychological vu lnerability were independently associated with eye and airway symptoms elicited by fragrance products, but adjustment in multivariate analysis did not change th e results regarding perfume contact allergy and hand eczema. Conclusions:Indivi duals with perfume contact allergy and/or hand eczema, as opposed to those witho ut, have more frequent and more severe eye or airway symptoms after exposure to volatile fragrance products. Having hand eczema has the greatest impact on repor ting eye and airway symptoms elicited by fragrance products.
