目的探讨三氧自体输血在改善脑卒中恢复期患者意识状态和运动功能中的疗效。方法选取2016年8月~2021年9月在本院康复科接受治疗并确诊为脑卒中恢复期的患者共44例,采用盲法随机分为实验组(n=22,三氧自体输血治疗,采集患者肘正中静脉血20...目的探讨三氧自体输血在改善脑卒中恢复期患者意识状态和运动功能中的疗效。方法选取2016年8月~2021年9月在本院康复科接受治疗并确诊为脑卒中恢复期的患者共44例,采用盲法随机分为实验组(n=22,三氧自体输血治疗,采集患者肘正中静脉血200 mL,间隔2~3 d 1次,12次为1个疗程,同时进行一般康复训练(即运动疗法、作业疗法、针灸治疗、经颅磁刺激技术治疗)和对照组(一般康复训练),对2组患者治疗前后的意识状态(GCS评分)、日常生活能力(Barthel指数评分)得分情况统计与比较分析,并观察评估上田敏运动功能分级、Brunnstrom分期、肌张力分级。结果实验(治疗)结束后,实验组与对照组比较:1)GCS评分为14.82±0.39 vs 12.41±2.52、Barthel评分为61.14±12.24 vs 52.05±11.72(P<0.05);2)运动功能恢复率为95.45%(21/22)vs 63.64%(14/22)(P<0.05);3)肌张力总恢复率为90.91%(20/22)vs 63.64%(14/22)(P<0.05)。结论三氧自体输血对于脑卒中恢复期患者的意识状态、运动功能和肌张力有一定的改善作用,具备较高的安全性和有效性。展开更多
Objective: To investigate the inhibitory effect of apogossypolone (ApoG2) on prostate cancer cell line PC-3 in vivo, and explore its mechanism. Methods: The models of transplantation tumors in Balb/c nu/nu mice were e...Objective: To investigate the inhibitory effect of apogossypolone (ApoG2) on prostate cancer cell line PC-3 in vivo, and explore its mechanism. Methods: The models of transplantation tumors in Balb/c nu/nu mice were established via subcutaneous injection of PC-3 cells and the tumor-transplanted mice were divided into 4 groups: control group and three ApoG2 treatment groups, with 10 mice in each group. Volumes of the tumor were estimated every 2 d and the morphology of tumor tissues was observed. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and caspase-8 in tumor tissues. Results: ApoG2 (2.5 mg/kg-10 mg/kg) given intraperitoneally once a day can obviously inhibit the growth of subcutaneous prostatic carcinoma implant. The tumor volume decreased obviously when the treatment dosage was bigger than 5.0 mg/kg (P<0.01). Meanwhile, ApoG2 decreased the expression of PCNA and CD31, and enhanced the expression of caspases-3, caspase-8 in tumor tissues. Conclusion: ApoG2 exert an inhibitory effect on prostatic carcinoma possibly by inducing apoptosis and inhibiting tumor angiogenesis.展开更多
文摘目的探讨三氧自体输血在改善脑卒中恢复期患者意识状态和运动功能中的疗效。方法选取2016年8月~2021年9月在本院康复科接受治疗并确诊为脑卒中恢复期的患者共44例,采用盲法随机分为实验组(n=22,三氧自体输血治疗,采集患者肘正中静脉血200 mL,间隔2~3 d 1次,12次为1个疗程,同时进行一般康复训练(即运动疗法、作业疗法、针灸治疗、经颅磁刺激技术治疗)和对照组(一般康复训练),对2组患者治疗前后的意识状态(GCS评分)、日常生活能力(Barthel指数评分)得分情况统计与比较分析,并观察评估上田敏运动功能分级、Brunnstrom分期、肌张力分级。结果实验(治疗)结束后,实验组与对照组比较:1)GCS评分为14.82±0.39 vs 12.41±2.52、Barthel评分为61.14±12.24 vs 52.05±11.72(P<0.05);2)运动功能恢复率为95.45%(21/22)vs 63.64%(14/22)(P<0.05);3)肌张力总恢复率为90.91%(20/22)vs 63.64%(14/22)(P<0.05)。结论三氧自体输血对于脑卒中恢复期患者的意识状态、运动功能和肌张力有一定的改善作用,具备较高的安全性和有效性。
文摘Objective: To investigate the inhibitory effect of apogossypolone (ApoG2) on prostate cancer cell line PC-3 in vivo, and explore its mechanism. Methods: The models of transplantation tumors in Balb/c nu/nu mice were established via subcutaneous injection of PC-3 cells and the tumor-transplanted mice were divided into 4 groups: control group and three ApoG2 treatment groups, with 10 mice in each group. Volumes of the tumor were estimated every 2 d and the morphology of tumor tissues was observed. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and caspase-8 in tumor tissues. Results: ApoG2 (2.5 mg/kg-10 mg/kg) given intraperitoneally once a day can obviously inhibit the growth of subcutaneous prostatic carcinoma implant. The tumor volume decreased obviously when the treatment dosage was bigger than 5.0 mg/kg (P<0.01). Meanwhile, ApoG2 decreased the expression of PCNA and CD31, and enhanced the expression of caspases-3, caspase-8 in tumor tissues. Conclusion: ApoG2 exert an inhibitory effect on prostatic carcinoma possibly by inducing apoptosis and inhibiting tumor angiogenesis.
