Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation, which frequently appear in a variety of single el...Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation, which frequently appear in a variety of single electron oxidation reactions for synthesizing structurally diverse functionalized indoles and indolines. Electrocatalysis is considered as a synthetically attractive and environmentally friendly alternative for driving the single electron oxidation of indoles. Remarkable achievements in electrocatalytic indolederived radical cation-mediated indole functionalization have been realized so far. This review comprehensively summarizes the recent progresses in the applications of electrocatalytic indole radical cations,including C(sp~2)–H functionalization, dearomative 2,3-difunctionalization, and ring-opening reaction, emphasizing the vital single electron oxidation steps of indoles, the substrates scope and limitations, and the reaction mechanisms.展开更多
A new,gen era I palladium-catalyzed oxidative strategy for the cleavage of the C=C triple bond is presented.By employing PdCI2/CuBr2/TEMPO and air as the catalytic system and H2O as the carbonyl oxygen atom source,a w...A new,gen era I palladium-catalyzed oxidative strategy for the cleavage of the C=C triple bond is presented.By employing PdCI2/CuBr2/TEMPO and air as the catalytic system and H2O as the carbonyl oxygen atom source,a wide range of 2-alkynyl carbonyl compounds,including 1,3-disubstituted prop-2-yn-l-ones,propiolamides and propiolates,lost an alkynyl carbon to access various 1,2-dicarbonyl compounds,e.g.,1,2-diones,2-keto amides and 2-keto esters,through Wacker oxidation,intramolecular cyclization and C—C bond cleavage cascades.展开更多
基金the National Natural Science Foundation of China (No.22261019)the Jiangxi Provincial Natural Science Foundation (No.20224BAB213004)+1 种基金the Education Department of Jiangxi Province(Nos.GJJ211134 and GJJ211137)the PhD start-up fund of Jiangxi Science&Technology Normal University (No.2021BSQD32) for financial support。
文摘Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation, which frequently appear in a variety of single electron oxidation reactions for synthesizing structurally diverse functionalized indoles and indolines. Electrocatalysis is considered as a synthetically attractive and environmentally friendly alternative for driving the single electron oxidation of indoles. Remarkable achievements in electrocatalytic indolederived radical cation-mediated indole functionalization have been realized so far. This review comprehensively summarizes the recent progresses in the applications of electrocatalytic indole radical cations,including C(sp~2)–H functionalization, dearomative 2,3-difunctionalization, and ring-opening reaction, emphasizing the vital single electron oxidation steps of indoles, the substrates scope and limitations, and the reaction mechanisms.
基金the National Natural Scienee Foundation of China(Nos.21625203 and 21871126)the Opening Fund of KLCBTCMR,Ministry of Education(No.KLCBTCMR18-02)for financial support.
文摘A new,gen era I palladium-catalyzed oxidative strategy for the cleavage of the C=C triple bond is presented.By employing PdCI2/CuBr2/TEMPO and air as the catalytic system and H2O as the carbonyl oxygen atom source,a wide range of 2-alkynyl carbonyl compounds,including 1,3-disubstituted prop-2-yn-l-ones,propiolamides and propiolates,lost an alkynyl carbon to access various 1,2-dicarbonyl compounds,e.g.,1,2-diones,2-keto amides and 2-keto esters,through Wacker oxidation,intramolecular cyclization and C—C bond cleavage cascades.
