Prediction of Time Series Empowered with a Novel SREKRLS Algorithm

For the unforced dynamical non-linear state–space model,a new Q1 and efficient square root extended kernel recursive least square estimation algorithm is developed in this article.The proposed algorithm lends itself towards the parallel implementation as in the FPGA systems.With the help of an ortho-normal triangularization method,which relies on numerically stable givens rotation,matrix inversion causes a computational burden,is reduced.Matrix computation possesses many excellent numerical properties such as singularity,symmetry,skew symmetry,and triangularity is achieved by using this algorithm.The proposed method is validated for the prediction of stationary and non-stationary Mackey–Glass Time Series,along with that a component in the x-direction of the Lorenz Times Series is also predicted to illustrate its usefulness.By the learning curves regarding mean square error(MSE)are witnessed for demonstration with prediction performance of the proposed algorithm from where it’s concluded that the proposed algorithm performs better than EKRLS.This new SREKRLS based design positively offers an innovative era towards non-linear systolic arrays,which is efficient in developing very-large-scale integration(VLSI)applications with non-linear input data.Multiple experiments are carried out to validate the reliability,effectiveness,and applicability of the proposed algorithm and with different noise levels compared to the Extended kernel recursive least-squares(EKRLS)algorithm.

Gly-LysPred: Identification of Lysine Glycation Sites in Protein Using Position Relative Features and Statistical Moments via Chou’s 5 Step Rule

Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a peptide.It is a clinically important attribute to numerous age-related,metabolic,and chronic diseases such as diabetes,Alzheimer’s,renal failure,etc.Identification of a non-enzymatic reaction are quite challenging in research.Manual identification in labs is a very costly and timeconsuming process.In this research,we developed an accurate,valid,and a robust model named as Gly-LysPred to differentiate the glycated sites from non-glycated sites.Comprehensive techniques using position relative features are used for feature extraction.An algorithm named as a random forest with some preprocessing techniques and feature engineering techniques was developed to train a computational model.Various types of testing techniques such as self-consistency testing,jackknife testing,and cross-validation testing are used to evaluate the model.The overall model’s accuracy was accomplished through self-consistency,jackknife,and cross-validation testing 100%,99.92%,and 99.88%with MCC 1.00,0.99,and 0.997 respectively.In this regard,a user-friendly webserver is also urbanized to accumulate the whole procedure.These features vectorization methods suggest that they can play a critical role in other web servers which are developed to classify lysine glycation.